Venturicidin A affects the mitochondrial membrane potential and induces kDNA loss in <em>Trypanosoma brucei</em> (Publications)
caused by trypanosomatid parasites have devastating health and economic consequences, especially in tropical areas. New drugs or new combination therapies to fight these parasites are urgently needed. V [...] is not fully understood. In this study, we tested venturicidin A on a panel of trypanosomatid parasites using Alamar Blue assays and found it to be highly active against Trypanosoma brucei and Leishmania [...] Additionally, we report the loss of mitochondrial DNA in approximately 40%-50%...
Arylmethylamino steroids as antiparasitic agents (Publications)
active against intraerythrocytic stages of chloroquine-sensitive and resistant Plasmodium falciparum parasites (IC50 1-5 nM) as well as against gametocytes. In P. berghei-infected mice, oral administration of [...] of 1o drastically reduces parasitaemia and cures the animals. Furthermore, 1o efficiently blocks parasite transmission from mice to mosquitoes. The steroid compounds show low cytotoxicity in mammalian cells [...] toxicity symptoms in mice. Moreover, 1o has a remarkable activity...
Nicolas Brancucci Appointed Professor at the University of Basel (News)
https://www.swisstph.ch/en/news/news-detail/news/nicolas-brancucci-appointed-professor-at-the-university-of-basel
in which the malaria parasite P. falciparum perceives its immediate environment within the human host and adapts its development cycle accordingly. It is now clear that the parasite closely links its gene [...] where he investigated epigenetic mechanisms controlling antigenic variation of the human malaria parasite Plasmodium falciparum . He then worked as a postdoctoral fellow in Boston (Harvard T. H. Chan School [...] Swiss TPH, a research programme will be developed to decipher the molecular...
Advances in metabolic profiling of experimental nematode and trematode infections (Publications)
metabolic profiling strategies applied to different host-parasite models in the laboratory. First, we emphasise the application of two parasitic worm infections that are particularly relevant for Southeast [...] for biomarker recovery. Moreover, metabonomics holds promise to enhance our understanding of host-parasite interactions at the metabolic level, and therefore provides a framework for discovery of novel targets [...] the metabolic responses in the hamster to a S. japonicum-N. americanus...
Advances in metabolic profiling of experimental nematode and trematode infections (Publications)
metabolic profiling strategies applied to different host-parasite models in the laboratory. First, we emphasise the application of two parasitic worm infections that are particularly relevant for Southeast [...] for biomarker recovery. Moreover, metabonomics holds promise to enhance our understanding of host-parasite interactions at the metabolic level, and therefore provides a framework for discovery of novel targets [...] the metabolic responses in the hamster to a S. japonicum-N. americanus...
A <em>Plasmodium falciparum</em> PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface (Publications)
Uniquely among malaria parasites, Plasmodium falciparum-infected erythrocytes (iRBCs) develop membrane protrusions, known as knobs, where the parasite adhesion receptor P. falciparum erythrocyte membrane [...] the parasite to the iRBC. A family of exported proteins featuring Plasmodium helical interspersed subtelomeric (PHIST) domains has attracted attention, with members being implicated in host-parasite protein [...] protein interactions and differentially regulated in severe disease and among...
A <em>Plasmodium falciparum</em> PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface (Publications)
Uniquely among malaria parasites, Plasmodium falciparum-infected erythrocytes (iRBCs) develop membrane protrusions, known as knobs, where the parasite adhesion receptor P. falciparum erythrocyte membrane [...] the parasite to the iRBC. A family of exported proteins featuring Plasmodium helical interspersed subtelomeric (PHIST) domains has attracted attention, with members being implicated in host-parasite protein [...] protein interactions and differentially regulated in severe disease and among...
Characterization of di-, tri-, and tetranucleotide microsatellite markers with perfect repeats for<em> Trypanosoma brucei</em> and related species (Publications)
brucei, unicellular parasites causing human sleeping sickness and animal nagana, have a great impact on the socio-economic environment of sub-Saharan Africa. The dynamics of the parasite are still poorly [...] questions in T. brucei to better understand the population structure and spread of this important parasite
Characterization of di-, tri-, and tetranucleotide microsatellite markers with perfect repeats for<em> Trypanosoma brucei</em> and related species (Publications)
brucei, unicellular parasites causing human sleeping sickness and animal nagana, have a great impact on the socio-economic environment of sub-Saharan Africa. The dynamics of the parasite are still poorly [...] questions in T. brucei to better understand the population structure and spread of this important parasite
Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria (Publications)
outcome of individuals infected with Plasmodium falciparum parasites depends on many factors including host systemic inflammatory responses, parasite sequestration in tissues and vascular dysfunction. Production [...] in turn triggers further endothelial cell activation and parasite sequestration. Inflammatory responses are triggered in part by bioactive parasite products such as hemozoin and infected red blood cell-derived
