Malaria importée: des médicaments tourjours plus efficaces et plus sûrs? (Publications)
the spread of parasite resistance to old antimalarial drugs, the large-scale implementation of artemisinine-based combinations has allowed to improving patient survival and reducing parasite transmission [...] n. Even though decreased susceptibility of parasites to artemisinine has been observed in South-East Asia, this phenomenon has no practical implications for travelers with uncomplicated malaria. The c
<em>Plasmodium</em> gene regulation: far more to factor in (Publications)
Gene expression in the malaria parasite has received generous attention over the past several decades, predominantly because of the importance of var gene regulation, which is key to antigenic variation [...] characterized. This mostly has been due to the lack of defined transcriptional regulators in Plasmodium parasites. Here, we describe recent advances that have become possible by joining traditional biochemistry [...] control of gene expression for antigenic variation but also in the...
Multilocus haplotypes reveal variable levels of diversity and population structure of <em>Plasmodium falciparum</em> in Papua New Guinea, a region of... (Publications)
distance suggesting that parasite populations are fragmented. Population structure was also identified between villages within the Malala area, with the haplotypes of one parasite population clustering with [...] in the low-lying inland areas. Local heterogeneity in the epidemiology of malaria suggests that parasites from multiple locations will need to be surveyed to define the population biology of P. falciparum [...] New Guinea. METHODS: Ten microsatellite loci were genotyped in 318 P....
Multilocus haplotypes reveal variable levels of diversity and population structure of <em>Plasmodium falciparum</em> in Papua New Guinea, a region of... (Publications)
distance suggesting that parasite populations are fragmented. Population structure was also identified between villages within the Malala area, with the haplotypes of one parasite population clustering with [...] in the low-lying inland areas. Local heterogeneity in the epidemiology of malaria suggests that parasites from multiple locations will need to be surveyed to define the population biology of P. falciparum [...] New Guinea. METHODS: Ten microsatellite loci were genotyped in 318 P....
Whipworm and roundworm infections (Publications)
species elicit type 2 anti-parasite immunity. Diagnosis is typically based on clinical presentation (gastrointestinal symptoms and inflammation) and the detection of eggs or parasite DNA in the faeces. Prevention [...] nematodes Trichuris trichiura (a whipworm) and Ascaris lumbricoides (a roundworm), respectively. Both parasites are staggeringly prevalent, particularly in tropical and subtropical areas, and are associated with [...] c drugs are needed, together with vaccine development and tools...
Parallelized impedance-based platform for continuous dose-response characterization of antischistosomal drugs (Publications)
Schistosomiasis is an acute and chronic disease caused by tropical parasitic worms of the genus Schistosoma, which parasitizes annually over 200 million people worldwide. Screening of antischistosomal [...] compounds is hampered by the low throughput and potential subjectivity of the visual evaluation of the parasite phenotypes, which affects the current drug assays. Here, an impedance-based platform, capable of [...] antipsychotic compound, which causes complex drug-induced effects. Continuous...
Humoral and cell-mediated immunity to the <em>Plasmodium falciparum</em> ring-infected erythrocyte surface antigen in an adult population exposed to... (Publications)
anti-RESA IgG antibodies were not correlated with protection against malaria as measured by parasite prevalence, parasite density, or health center attendance. In contrast, cytophilic antibodies (IgG1 and IgG3) [...] infrequent. No correlation between humoral and cellular immune responses could be found. Parasite density, parasite prevalence, and health center visits tended to be reduced in individuals with good humoral
Isothermal microcalorimetry, a new tool to monitor drug action against <em>Trypanosoma brucei</em> and <em>Plasmodium falciparum</em> (Publications)
and Plasmodium falciparum. Heat flow signals obtained for these pathogens allowed us to monitor parasite growth on a real-time basis as the signals correlated with the number of viable cells. To showcase [...] drugs, chloroquine, artemether and dihydroartemisinin, each at two concentrations on the respective parasite. With the real time measurement, inhibition was observed immediately by a reduced heat flow compared [...] control samples. The onset of drug action, the degree of inhibition and...
Parallelized impedance-based platform for continuous dose-response characterization of antischistosomal drugs (Publications)
Schistosomiasis is an acute and chronic disease caused by tropical parasitic worms of the genus Schistosoma, which parasitizes annually over 200 million people worldwide. Screening of antischistosomal [...] compounds is hampered by the low throughput and potential subjectivity of the visual evaluation of the parasite phenotypes, which affects the current drug assays. Here, an impedance-based platform, capable of [...] antipsychotic compound, which causes complex drug-induced effects. Continuous...
Humoral and cell-mediated immunity to the <em>Plasmodium falciparum</em> ring-infected erythrocyte surface antigen in an adult population exposed to... (Publications)
anti-RESA IgG antibodies were not correlated with protection against malaria as measured by parasite prevalence, parasite density, or health center attendance. In contrast, cytophilic antibodies (IgG1 and IgG3) [...] infrequent. No correlation between humoral and cellular immune responses could be found. Parasite density, parasite prevalence, and health center visits tended to be reduced in individuals with good humoral
