The influence of biological, epidemiological, and treatment factors on the establishment and spread of drug-resistant <em>Plasmodium falciparum</em> (Publications)
Spread of partial artemisinin resistance was slowed with prolonged parasite exposure to artemisinin derivatives and accelerated when the parasite was also resistant to the partner drug. Thus, to slow the spread [...] the lower levels of (i) immunity and (ii) within-host competition between genotypes. Spread of parasites resistant to artemisinin partner drugs depended on the period of low drug concentration (known as [...] . Furthermore, implementing more sustainable artemisinin-based therapies...
<em>Plasmodium vivax </em>molecular diagnostics in community surveys: pitfalls and solutions (Publications)
A distinctive feature of Plasmodium vivax infections is the overall low parasite density in peripheral blood. Thus, identifying asymptomatic infected individuals in endemic communities requires diagnostic [...] improved more than tenfold, compared to standard 18S rRNA targets, thereby allowing detection of lower parasite densities. In a very low transmission area in Brazil, application of a mitochondrial DNA-based assay [...] however, is the challenge of demonstrating test accuracy and quality...
Operational strategies of anti-malarial drug campaigns for malaria elimination in Zambia's southern province: a simulation study (Publications)
elimination requires reducing both the potential of mosquitoes to transmit parasites to humans and humans to transmit parasites to mosquitoes. To achieve this goal in Southern province, Zambia a mass test [...] approach was applied to investigate the simulated effect of alternative operational strategies for parasite clearance in southern province. METHODS: OpenMalaria, a discrete-time, individual-based stochastic [...] assess uncertainty of simulation results. Scenarios were evaluated based on...
Operational strategies of anti-malarial drug campaigns for malaria elimination in Zambia's southern province: a simulation study (Publications)
elimination requires reducing both the potential of mosquitoes to transmit parasites to humans and humans to transmit parasites to mosquitoes. To achieve this goal in Southern province, Zambia a mass test [...] approach was applied to investigate the simulated effect of alternative operational strategies for parasite clearance in southern province. METHODS: OpenMalaria, a discrete-time, individual-based stochastic [...] assess uncertainty of simulation results. Scenarios were evaluated based on...
Filariosen bei Tropenrückkehrern. Beobachtungen an 64 Fällen (Publications)
symptoms due to the low parasite density. Therefore, demonstration of the parasite, which is the diagnostic aim, is often very difficult and requires special techniques. Whenever parasite demonstration is impossible
Filariosen bei Tropenrückkehrern. Beobachtungen an 64 Fällen (Publications)
symptoms due to the low parasite density. Therefore, demonstration of the parasite, which is the diagnostic aim, is often very difficult and requires special techniques. Whenever parasite demonstration is impossible
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity (Publications)
digestion in asexual parasites. MMV1557817 can kill sexual-stage P. falciparum, is active against murine malaria, and does not show any shift in activity against a panel of parasites resistant to other [...] resistant P. falciparum exhibited a slow growth rate that was quickly outcompeted by wild-type parasites and were sensitized to the current clinical drug, artemisinin. Overall, these results confirm MMV1557817 [...] Their widespread use has led to the development of artemisinin resistance...
Re-annotation of the <em>Theileria parva</em> genome refines 53% of the proteome and uncovers essential components of N-glycosylation, a conserved... (Publications)
Comprehensive, accurate parasite genome annotation can facilitate the discovery of novel chemotherapeutic targets for disease treatment, as well as elucidate the biology of the parasite. However, genome annotation [...] sequences in this parasite, and uncovered a minimal N-glycosylation pathway that changes our current understanding of the evolution of this post-translational modification in apicomplexan parasites. [...] BACKGROUND: The apicomplexan parasite Theileria parva causes a livestock...
Strategies for detection of <em>Plasmodium species</em> gametocytes (Publications)
and asexual parasite stages, 18S rRNA transcript-based detection saves efforts and costs. RNA-based positivity is considerably higher than other methods. On the other hand, DNA-based parasite quantification [...] Carriage and density of gametocytes, the transmission stages of malaria parasites, are determined for predicting the infectiousness of humans to mosquitoes. This measure is used for evaluating interventions [...] species prevalence was determined by targeting both, 18S rRNA genes and...
Effectiveness of combined intermittent preventive treatment for children and timely home treatment for malaria control (Publications)
four months (three times in 12 months). Malaria parasite prevalence surveys were conducted before the first and after the third dose of IPTC. RESULTS: Parasite prevalence was reduced from 25% to 3% (p < 0 [...] timely treatment of febrile malaria illness, impacts significantly on the parasite prevalence. The marked reduction in the parasite prevalence with this strategy points to the potential for reducing mala [...] children (IPTC) and timely treatment of malaria-related febrile illness in the...
