Surveillance of molecular markers of <em>Plasmodium falciparum</em> artemisinin resistance (<em>kelch</em>13 mutations) in Papua New Guinea between... (Publications)
mutant parasites with reduced in vitro sensitivity to artemisinin have been isolated in Wewak, a port town in East Sepik Province. However, the extent of any local spread of these mutant parasites in other [...] mutant parasites were previously identified. The single C580Y isolate was found in the port town of Lae, Morobe Province, a potential entry site for the importation of drug resistant parasites into PNG [...] n efforts. Mutations in the P. falciparum kelch13 gene (Pfk13) that are...
Genetic diversity and protective efficacy of the RTS,S/AS01 malaria vaccine (Publications)
category will depend on the proportion of matched alleles in the local parasite population; in this trial, less than 10% of parasites had matched alleles. (Funded by the National Institutes of Health and [...] disease in infants and children. We investigated whether the vaccine efficacy was specific to certain parasite genotypes at the circumsporozoite protein locus. Methods We used polymerase chain reaction-based [...] efficacy was 50.3% (95% confidence interval [CI], 34.6 to 62.3) against...
Capture-based enrichment of <em>Theileria parva </em>DNA enables full genome assembly of first buffalo-derived strain and reveals exceptional... (Publications)
Theileria parva is an economically important, intracellular, tick-transmitted parasite of cattle. A live vaccine against the parasite is effective against challenge from cattle-transmissible T. parva but not [...] high specificity and sensitivity and is successful for both cattle- and buffalo-derived T. parva parasites. De novo genome assemblies generated for cattle genotypes differ from the reference by ~54K single [...] 44, reflecting a degree of genetic differentiation between cattle- and...
Surveillance of molecular markers of <em>Plasmodium falciparum</em> artemisinin resistance (<em>kelch</em>13 mutations) in Papua New Guinea between... (Publications)
mutant parasites with reduced in vitro sensitivity to artemisinin have been isolated in Wewak, a port town in East Sepik Province. However, the extent of any local spread of these mutant parasites in other [...] mutant parasites were previously identified. The single C580Y isolate was found in the port town of Lae, Morobe Province, a potential entry site for the importation of drug resistant parasites into PNG [...] n efforts. Mutations in the P. falciparum kelch13 gene (Pfk13) that are...
Genetic diversity and protective efficacy of the RTS,S/AS01 malaria vaccine (Publications)
category will depend on the proportion of matched alleles in the local parasite population; in this trial, less than 10% of parasites had matched alleles. (Funded by the National Institutes of Health and [...] disease in infants and children. We investigated whether the vaccine efficacy was specific to certain parasite genotypes at the circumsporozoite protein locus. Methods We used polymerase chain reaction-based [...] efficacy was 50.3% (95% confidence interval [CI], 34.6 to 62.3) against...
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary... (Publications)
Despite recent progress in the fight against malaria, the emergence and spread of drug-resistant parasites remains a serious obstacle to the treatment of infections. We recently reported the development [...] properties and mode of action were characterized in vitro and in vivo, and interactions with the parasite's 'chloroquine resistance transporter' were investigated in a Xenopus laevis oocyte expression system [...] 4b and 4d may be suitable for co-administration with chloroquine against...
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary... (Publications)
Despite recent progress in the fight against malaria, the emergence and spread of drug-resistant parasites remains a serious obstacle to the treatment of infections. We recently reported the development [...] properties and mode of action were characterized in vitro and in vivo, and interactions with the parasite's 'chloroquine resistance transporter' were investigated in a Xenopus laevis oocyte expression system [...] 4b and 4d may be suitable for co-administration with chloroquine against...
Armin Passecker (People)
https://www.swisstph.ch/en/staff/profile/people/armin-passecker
be exported in asexual blood stage parasites in gametocytes. Therefore, antibodies targeting proteins localizing at Maurer`s clefts and tethers in asexual parasites will be used to track the fate of those [...] Supervisors: Till Voss / Hans-Peter Beck Proposal abstract Besides asexual replication, Plasmodium parasites can choose an alternative development pathway within the human host leading to mature stage V g [...] mosquitos during the blood meal and following progression through several...
Synthesis and evaluation of 2-pyridyl pyrimidines with in vitro antiplasmodial and antileishmanial activity (Publications)
screening of the library against cultured Leishmania donovani parasites revealed this class of compounds as potent inhibitors of parasite development in vitro
Synthesis and evaluation of 2-pyridyl pyrimidines with in vitro antiplasmodial and antileishmanial activity (Publications)
screening of the library against cultured Leishmania donovani parasites revealed this class of compounds as potent inhibitors of parasite development in vitro
