Challenges in malaria management and a glimpse at some nanotechnological approaches (Publications)
provides tools to design strategies to target drug molecules to specific stages of the parasite, treat drug-resistant parasites, resolve severe malaria, increase vaccine efficacies and combinations thereof. This [...] past years, there are still considerable challenges to be solved. To name a few, drug-resistant parasites, insecticide-resistant mosquitoes and the difficulty to formulate a potent malaria vaccine need
Novel 1-methyl-1 <em>H</em>-pyrazole-5-carboxamide derivatives with potent anthelmintic activity (Publications)
selectivity toward the parasite when tested in vitro against the human MCF10A cell line. In addition, compounds 9 and 27 showed promising activity against a panel of other parasitic nematodes, including [...] screen of two different libraries of small molecules against the motility and development of the parasitic nematode Haemonchus contortus led to the identification of two 1-methyl-1 H-pyrazole-5-carboxamide
Egg-laying and locomotory screens with <em>C. elegans </em>yield a nematode-selective small molecule stimulator of neurotransmitter release (Publications)
Nematode parasites of humans, livestock and crops dramatically impact human health and welfare. Alarmingly, parasitic nematodes of animals have rapidly evolved resistance to anthelmintic drugs, and traditional [...] This work yielded multiple compounds that selectively kill and/or immobilize diverse nematode parasites. We focus on one compound that induces violent convulsions and paralysis that we call nementin.
The source of individual heterogeneity shapes infectious disease outbreaks (Publications)
duration and transmission rate in parasite emergence and spread, while controlling for this potential bias, we simulate stochastic outbreaks with and without parasite evolution. As expected, heterogeneity [...] realistic infection duration distributions leads to faster outbreaks and higher epidemic peaks. When parasites require adaptive mutations to cause large epidemics, the impact of heterogeneity depends on the
The <em>in vitro</em> distribution of halofantrine in human blood and <em>Plasmodium falciparum</em>-parasitised red blood cells (Publications)
in normal erythrocytes. The amount of accumulated drug depended on the parasite stage and presence of serum, since mature parasites showed the highest accumulation, and serum reduced drug accumulation compared [...] of halofantrine into Plasmodium falciparum-parasitised red blood cells was measured at different parasite stages and with varying serum concentrations. Halofantrine accumulated in P. falciparum-parasitised
Estimating <em>Plasmodium falciparum</em> transmission rates in low-endemic settings using a combination of community prevalence and health facility... (Publications)
transmission. In this paper, we propose an approach for combining annual parasite incidence and treatment data with cross-sectional parasite prevalence and treatment seeking survey data to estimate the incidence [...] precisely, for example through entomological studies. Many programs conduct regular cross sectional parasite prevalence surveys, and have access to malaria treatment data routinely collected by ministries
Estimating <em>Plasmodium falciparum</em> transmission rates in low-endemic settings using a combination of community prevalence and health facility... (Publications)
transmission. In this paper, we propose an approach for combining annual parasite incidence and treatment data with cross-sectional parasite prevalence and treatment seeking survey data to estimate the incidence [...] precisely, for example through entomological studies. Many programs conduct regular cross sectional parasite prevalence surveys, and have access to malaria treatment data routinely collected by ministries
The source of individual heterogeneity shapes infectious disease outbreaks (Publications)
duration and transmission rate in parasite emergence and spread, while controlling for this potential bias, we simulate stochastic outbreaks with and without parasite evolution. As expected, heterogeneity [...] realistic infection duration distributions leads to faster outbreaks and higher epidemic peaks. When parasites require adaptive mutations to cause large epidemics, the impact of heterogeneity depends on the
Egg-laying and locomotory screens with <em>C. elegans </em>yield a nematode-selective small molecule stimulator of neurotransmitter release (Publications)
Nematode parasites of humans, livestock and crops dramatically impact human health and welfare. Alarmingly, parasitic nematodes of animals have rapidly evolved resistance to anthelmintic drugs, and traditional [...] This work yielded multiple compounds that selectively kill and/or immobilize diverse nematode parasites. We focus on one compound that induces violent convulsions and paralysis that we call nementin.
The <em>in vitro</em> distribution of halofantrine in human blood and <em>Plasmodium falciparum</em>-parasitised red blood cells (Publications)
in normal erythrocytes. The amount of accumulated drug depended on the parasite stage and presence of serum, since mature parasites showed the highest accumulation, and serum reduced drug accumulation compared [...] of halofantrine into Plasmodium falciparum-parasitised red blood cells was measured at different parasite stages and with varying serum concentrations. Halofantrine accumulated in P. falciparum-parasitised
