Resisting infection by <em>Plasmodium berghei</em> increases the sensitivity of the malaria vector <em>Anopheles gambiae</em> to DDT (Publications)
sporozoites (the infectious stage of the Plasmodium parasite) and they are relatively old, as they need to survive the development period of the malaria parasite. This study examines the effects of infection [...] mosquitoes that had fed on Plasmodium-infected mice than in those that had not been exposed to the parasite. The latter effect was mainly due to the high sensitivity of mosquitoes that had fed on an infected [...] those that had fed on an uninfected mouse. CONCLUSIONS: The observed...
Blood-stage parasitaemia and age determine <em>Plasmodium falciparum</em> and <em>P. vivax</em> gametocytaemia in Papua New Guinea (Publications)
gametocytes by detection of pfs25 and pvs25 mRNA transcripts by reverse-transcriptase PCR (qRT-PCR). The parasite prevalence by PCR was 18.5% for Plasmodium falciparum and 13.0% for P. vivax. 52.5% of all infections [...] in 60% of P. falciparum-positive and 51% of P. vivax-positive samples. Each 10-fold increase in parasite density led to a 1.8-fold and 3.3-fold increase in the odds of carrying P. falciparum and P. vivax [...] gametocyte positive and gametocyte densities was highest in young...
Discovery of dual function acridones as a new antimalarial chemotype (Publications)
an immutable and vulnerable target, because it is not parasite-encoded and its detoxification during haemoglobin degradation, critical to parasite survival, can be subverted by drug-haem interaction as [...] 'verapamil-like' chemosensitization to chloroquine and amodiaquine against quinoline-resistant parasites, T3.5 also results in an apparently mechanistically distinct synergism with quinine and with piperaquine [...] piperaquine. This synergy, evident in both quinoline-sensitive and...
Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in <em>Toxoplasma gondii</em> (Publications)
Treatment of parasites with low micromolar concentrations of beta-lactone- or triazole urea-based inhibitors that target human APT1 showed varied detrimental effects at multiple steps of the parasite lytic cycle [...] contributes to key biological processes in Apicomplexa with the recent palmitome of the malaria parasite Plasmodium falciparum reporting over 400 substrates that are modified with palmitate by a broad [...] similar to APTs, and homology modeling points toward an APT-like enzyme....
<em>In vitro</em> and<em> in vivo</em> activity of Solithromycin (CEM-101) against <em>Plasmodium</em> species (Publications)
With the emergence of Plasmodium falciparum infections exhibiting increased parasite clearance times in response to treatment with artemisinin-based combination therapies, the need for new therapeutic [...] in development, has been shown to be an effective, broad-spectrum antimicrobial agent. Malarial parasites possess an unusual organelle, termed the apicoplast, which carries a cryptic genome of prokaryotic [...] macrolide azithromycin, demonstrate a "delayed death" effect, whereby treated...
Induction of humoral immune response to multiple recombinant <em>Rhipicephalus appendiculatus</em> antigens and their effect on tick feeding success... (Publications)
natural host-tick-parasite combination. In spite of evidence of strong immune responses to all of the antigens in the cocktail, vaccination with this combination of tick and parasite antigens did not appear [...] appendiculatus feeding success and possibly reduce tick-transmission of T. parva in a natural host-tick-parasite challenge model. METHODS: Cattle were inoculated with a multivalent antigen cocktail containing [...] anti-tick vaccine candidates in biologically relevant challenge systems...
Monitoring <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> using microsatellite markers indicates limited changes in population structure... (Publications)
human malaria parasites, Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) following nationwide distribution of long-lasting insecticide treated nets (LLIN) in Papua New Guinea (PNG). Parasite isolates from [...] Despite parasite prevalence declining substantially (East Sepik Province: Pf=54.9-8.5%, Pv=35.7-5.6%, Madang Province: Pf=38.0-9.0%, Pv: 31.8-19.7%), genetically diverse and intermixing parasite populations [...] significant multilocus linkage disequilibrium (mLD) post-LLIN was a...
Mechanistic within-host models of the asexual <em>Plasmodium falciparum</em> infection: a review and analytical assessment (Publications)
mechanisms of parasite growth and the host's immune response during infection remain largely unknown. Over the last 30 years, several mechanistic mathematical models of malaria parasite within-host dynamics [...] Models have attempted to capture the considerable variability in parasite dynamics between individuals by including stochastic parasite multiplication rates; variant switching dynamics leading to immune [...] been published and used in malaria transmission models. METHODS:...
Two-year evaluation of Intermittent Preventive Treatment for Children (IPTc) combined with timely home treatment for malaria control in Ghana (Publications)
children (IPTc) combined with timely treatment of malaria related febrile illness at home to reduce parasite prevalence and malaria morbidity in children aged between six and 60 months in a coastal community [...] objective in the second year was to demonstrate whether the two interventions would further reduce parasite prevalence and malaria-related febrile illness in the study population. METHODS: This was an in [...] artesunate, delivered at home by community assistants every four months (6...
Monitoring <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> using microsatellite markers indicates limited changes in population structure... (Publications)
human malaria parasites, Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) following nationwide distribution of long-lasting insecticide treated nets (LLIN) in Papua New Guinea (PNG). Parasite isolates from [...] Despite parasite prevalence declining substantially (East Sepik Province: Pf=54.9-8.5%, Pv=35.7-5.6%, Madang Province: Pf=38.0-9.0%, Pv: 31.8-19.7%), genetically diverse and intermixing parasite populations [...] significant multilocus linkage disequilibrium (mLD) post-LLIN was a...
