The relative contribution of climate variability and vector control coverage to changes in malaria parasite prevalence in Zambia 2006-2012 (Publications)
insecticide-treated nets (ITNs) and indoor residual spraying (IRS) increased over this period, while parasite prevalence in children 1-59 months decreased dramatically between 2006 and 2008, but then increased [...] We assessed the relative effects of vector control coverage and climate variability on malaria parasite prevalence over this period. METHODS: Nationally-representative MISs were conducted in April-June [...] evel information on malaria control interventions such as IRS, ITN...
Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody (Publications)
present the crystal structure of PfCyRPA and of its complex with the antigen-binding fragment of a parasite growth inhibitory antibody. While PfCyRPA adopts a 6-bladed beta-propeller structure with similarity [...] protective epitopes. Both in vitro and in vivo anti-PfCyRPA and anti-PfRH5 antibodies showed more potent parasite growth inhibitory activity in combination than on their own, supporting a combined delivery of PfCyRPA
Dynamics of anemia in relation to parasitic infections, micronutrient status, and growing age in south-central Côte d'Ivoire (Publications)
Background. Parasitic diseases (e.g., malaria and helminthiases) exert enormous burdens on public health and social wellbeing. Moreover, parasitic infections are important causes of anemia in tropical [...] parameters.Conclusions. Our results call for effective prevention and control measures targeting parasitic diseases and iron deficiency. These measures might include the distribution of long-lasting insecticidal
Disparities in parasitic infections, perceived ill health and access to health care among poorer and less poor schoolchildren of rural Côte... (Publications)
schoolchildren's parasitic infection status, perceived ill health and access to health care in a large rural part of Cote d'Ivoire. These findings call for more equity-balanced parasitic disease control [...] only few studies analysed inequities within poor rural communities. We investigated disparities in parasitic infections, perceived ill health and access to formal health services among more than 4000 scho
An immigration-death model to estimate the duration of malaria infection when detectability of the parasite is imperfect (Publications)
studies of panels of heavily parasitized human hosts where parasites have been typed at regular intervals by PCR. Immigration refers to the acquisition of a new parasitic genotype, occurring at rate lambda [...] refers to the clearance of a parasitic genotype (with rate mu). The models assume that corresponding to each observed process which is the detection or failure to detect a parasitic genotype, is an underlying [...] represent the habitat of the parasites, and (ii) a model that allows for...