Effect of the malaria vaccine combination B on merozoite surface antigen 2 diversity (Publications)
to assess possible effects of a polymorphic vaccine, we have analyzed the genetic diversity of parasites collected in the course of a phase 2b field trial of the blood stage vaccine Combination B in Papua [...] (MSP2) was included in Combination B as one of three subunits. Vaccinees had a lower prevalence of parasites carrying a 3D7-type allele (corresponding to that in the vaccine) and selection appeared to favour [...] FC27-type alleles resulting in a higher incidence of morbid episodes...
<em>Plasmodium falciparum </em>malaria disease manifestations in humans and transmission to<em> Anopheles gambiae</em>: a field study in Western Kenya (Publications)
Transmission of the malaria parasite Plasmodium is influenced by many different host, vector and parasite factors. Here we conducted a field study at Mbita, an area of endemic malaria in Western Kenya [...] Kenya, to test whether parasite transmission to mosquitoes is influenced by the severity of malaria infection in its human host at the time when gametocytes, the transmission forms, are present in the peripheral [...] abundance, but also to the higher level of infectivity of their...
Pharmacokinetics, <em>Trypanosoma brucei gambiense</em> efficacy and time of drug action of DB829, a preclinical candidate for treatment of second... (Publications)
sleeping sickness), a neglected tropical disease endemic to sub-Saharan Africa, is caused by the parasites Trypanosoma brucei (T. b.) gambiense and T. b. rhodesiense. Current drugs have significant limitations [...] e that demonstrated excellent efficacy in mice infected with T. b. rhodesiense or T. b. brucei parasites. Current study examined pharmacokinetics, in vitro and in vivo activity against T. b. gambiense [...] in comparison to pentamidine. DB829 showed outstanding in vivo efficacy in...
Effect of the malaria vaccine combination B on merozoite surface antigen 2 diversity (Publications)
to assess possible effects of a polymorphic vaccine, we have analyzed the genetic diversity of parasites collected in the course of a phase 2b field trial of the blood stage vaccine Combination B in Papua [...] (MSP2) was included in Combination B as one of three subunits. Vaccinees had a lower prevalence of parasites carrying a 3D7-type allele (corresponding to that in the vaccine) and selection appeared to favour [...] FC27-type alleles resulting in a higher incidence of morbid episodes...
Inhibition of <em>Leishmania donovani</em> transformation by hamster spleen homogenates and active human lymphocytes (Publications)
protozoan parasites responsible for many important diseases of man and domestic animals1. Leishmania donovani, the cause of visceral leishmaniasis or kala azar, is a widespread human parasitic haemoflagellate
Histone methyltransferase inhibitors are orally bioavailable, fast acting molecules with activity against different species causing malaria in humans (Publications)
threat due to the relentless development of drug resistance by malaria parasites. We previously reported promising in vitro parasite killing activity with the histone methyltransferase inhibitor BIX-01294
Histone methyltransferase inhibitors are orally bioavailable, fast acting molecules with activity against different species causing malaria in humans (Publications)
threat due to the relentless development of drug resistance by malaria parasites. We previously reported promising in vitro parasite killing activity with the histone methyltransferase inhibitor BIX-01294
Inhibition of <em>Leishmania donovani</em> transformation by hamster spleen homogenates and active human lymphocytes (Publications)
protozoan parasites responsible for many important diseases of man and domestic animals1. Leishmania donovani, the cause of visceral leishmaniasis or kala azar, is a widespread human parasitic haemoflagellate
Isothermal microcalorimetry – a quantitative method to monitor <em>Trypanosoma congolense</em> growth and growth inhibition by trypanocidal drugs in... (Publications)
highly sensitive tool that can be used to study growth of the extracellular T. congolense parasites or to study parasite growth inhibition after the addition of antitrypanosomal drugs. Time of drug action and [...] Trypanosoma congolense is a protozoan parasite that is transmitted by tsetse flies, causing African Animal Trypanosomiasis, also known as Nagana, in sub-Saharan Africa. Nagana is a fatal disease of livestock
A major surface glycoprotein of <em>Trypanosoma brucei</em> is expressed transiently during development and can be regulated post- transcriptionally... (Publications)
Differentiation is a means by which unicellular parasites adapt to different environments. In some cases, the developmental program may be modulated by interactions with the host, but the mechanisms are [...] repressed after 7-9 days. The timepoint at which GPEET is repressed coincides with the appearance of parasites in a new compartment of the fly midgut. In culture, down- regulation of GPEET can be prevented by [...] defined window during the establishment of infection suggests that it has a...
