Laboratory selection of trypanosomatid pathogens for drug resistance (Publications)
The selection of parasites for drug resistance in the laboratory is an approach frequently used to investigate the mode of drug action, estimate the risk of emergence of drug resistance, or develop molecular [...] drug resistance performed in vivo or in vitro? With the mammalian or with the insect stages of the parasites? Under steady pressure or by sudden shock? Is a mutagen used? While there is no bona fide best approach [...] that a methodical consideration of these questions provides a...
2-(Nitroaryl)-5-substituted-1,3,4-thiadiazole derivatives with antiprotozoal activities: <em>in vitro</em> and <em>in vivo </em>study (Publications)
ve agents, especially in the field of anti-parasitic drug discovery. HAT or sleeping sickness is a neglected tropical disease caused by a protozoan parasite, Trypanosoma brucei. Following the approval [...] gambiense HAT, there is an increased interest in developing new nitro-containing compounds against parasitic diseases. In our previous projects, we synthesized several megazole derivatives that presented high
Polyparasitism with <em>Schistosoma mansoni,</em> geohelminths, and intestinal protozoa in rural Côte d'Ivoire (Publications)
infection, whereas two-thirds of the population harbored 3 or more parasites concurrently. There were a series of significant pairwise parasite co-occurrences, e.g., between S. mansoni and hookworms and between [...] sub-Saharan Africa. These findings call for integrated approaches to effectively control multiple parasitic and protozoan infections
Laboratory selection of trypanosomatid pathogens for drug resistance (Publications)
The selection of parasites for drug resistance in the laboratory is an approach frequently used to investigate the mode of drug action, estimate the risk of emergence of drug resistance, or develop molecular [...] drug resistance performed in vivo or in vitro? With the mammalian or with the insect stages of the parasites? Under steady pressure or by sudden shock? Is a mutagen used? While there is no bona fide best approach [...] that a methodical consideration of these questions provides a...
Nicolas Brancucci (People)
https://www.swisstph.ch/en/staff/profile/people/nicolas-brancucci
interactions between malaria parasites and their human host cells. In current projects, his team studies nutrient sensing and erythrocyte invasion of Plasmodium falciparum parasites. Nicolas Brancucci obtained [...] intimate links that exist between P. falciparum metabolism, gene regulation and the exposure of parasites to different host microenvironments. In 2017, he re-joined the Swiss TPH to establish new drug screening
2-(Nitroaryl)-5-substituted-1,3,4-thiadiazole derivatives with antiprotozoal activities: <em>in vitro</em> and <em>in vivo </em>study (Publications)
ve agents, especially in the field of anti-parasitic drug discovery. HAT or sleeping sickness is a neglected tropical disease caused by a protozoan parasite, Trypanosoma brucei. Following the approval [...] gambiense HAT, there is an increased interest in developing new nitro-containing compounds against parasitic diseases. In our previous projects, we synthesized several megazole derivatives that presented high
Polyparasitism with <em>Schistosoma mansoni,</em> geohelminths, and intestinal protozoa in rural Côte d'Ivoire (Publications)
infection, whereas two-thirds of the population harbored 3 or more parasites concurrently. There were a series of significant pairwise parasite co-occurrences, e.g., between S. mansoni and hookworms and between [...] sub-Saharan Africa. These findings call for integrated approaches to effectively control multiple parasitic and protozoan infections
A major surface glycoprotein of <em>Trypanosoma brucei</em> is expressed transiently during development and can be regulated post- transcriptionally... (Publications)
Differentiation is a means by which unicellular parasites adapt to different environments. In some cases, the developmental program may be modulated by interactions with the host, but the mechanisms are [...] repressed after 7-9 days. The timepoint at which GPEET is repressed coincides with the appearance of parasites in a new compartment of the fly midgut. In culture, down- regulation of GPEET can be prevented by [...] defined window during the establishment of infection suggests that it has a...
Isothermal microcalorimetry – a quantitative method to monitor <em>Trypanosoma congolense</em> growth and growth inhibition by trypanocidal drugs in... (Publications)
highly sensitive tool that can be used to study growth of the extracellular T. congolense parasites or to study parasite growth inhibition after the addition of antitrypanosomal drugs. Time of drug action and [...] Trypanosoma congolense is a protozoan parasite that is transmitted by tsetse flies, causing African Animal Trypanosomiasis, also known as Nagana, in sub-Saharan Africa. Nagana is a fatal disease of livestock
Une nouvelle découverte dévoile le mécanisme d'invasion du paludisme (News)
https://www.swisstph.ch/en/news/news-detail/news/une-nouvelle-decouverte-devoile-le-mecanisme-dinvasion-du-paludisme
inhibitrice du parasite des anticorps spécifiques de CyRPA», a déclaré Gerd Pluschke, responsable du groupe d'immunologie moléculaire au Swiss TPH, et co-auteur de la publication. Le parasite du paludisme [...] ciblage spécifique à l'espèce des parasites du paludisme. Dans cette étude, nous montrons que la forme humaine de l'acide sialique, Neu5Ac, est fortement préférée par le parasite du paludisme P. falciparum [...] paludisme et 608 000 décès en 2022, le paludisme reste une...
