2,4-diaminopyrimidines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase (Publications)
were then assayed against the recombinant parasite and human enzymes. Some of the compounds showed good activity. They were also tested against the intact parasites using in vitro assays. Good activity was
A systematic literature review of microscopy methods reported in malaria clinical trials (Publications)
stained blood films is essential for the diagnosis of malaria, differentiation of parasite species, and estimation of parasite density performed for assessments of antimalarial drug efficacy. The accuracy
A systematic literature review of microscopy methods reported in malaria clinical trials (Publications)
stained blood films is essential for the diagnosis of malaria, differentiation of parasite species, and estimation of parasite density performed for assessments of antimalarial drug efficacy. The accuracy
Detection of arsenical drug resistance in <em>Trypanosoma brucei</em> with a simple fluorescence test [Research letters] (Publications)
simple, and sensitive test for identification of parasites resistant to melarsoprol, the main drug used to treat late stage HAT. Resistant parasites are defective in a plasma membrane transporter responsible
2,4-diaminopyrimidines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase (Publications)
were then assayed against the recombinant parasite and human enzymes. Some of the compounds showed good activity. They were also tested against the intact parasites using in vitro assays. Good activity was
Case report: Molecular diagnosis of subcutaneous <em>Spirometra erinaceieuropaei</em> sparganosis in a Japanese immigrant (Publications)
umbilicus with a palpable subcutaneous cherry-sized lump. Polymerase chain reaction on formalin-fixed parasite tissue identified Spirometra erinaceieuropaei as the causative agent; the proliferative form of [...] an immunofluorescence test was established and revealed an antibody response directed against the parasite's tegument. Histological key features of the plerocercoid that facilitate diagnosis with different
eLearning (Page)
https://www.swisstph.ch/en/study-with-us/elearning
applets to visualise and experiment with statistical concepts. Parasitology and Parasitism Providing basic knowledge about parasitism and parasitology (in German) This eLearning programme was already designed [...] course with a virtual microscope At Swiss TPH there is almost 70 years of experience in diagnosing parasitic diseases. The aim of this eLearning programme is to bring all this experience and expertise together [...] attractive and interactive product addressing the multifaceted and...
Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents (Publications)
(TLM) have been synthesised and evaluated for their ability to inhibit the growth of the malaria parasite, Plasmodium falciparum. Thiolactomycin is an inhibitor of Type II fatty acid synthase which is found [...] activity over TLM. In addition, some of the analogues showed activity when assayed against the parasitic protozoa, Trypanosoma cruzi and Trypanosoma brucei
Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents (Publications)
(TLM) have been synthesised and evaluated for their ability to inhibit the growth of the malaria parasite, Plasmodium falciparum. Thiolactomycin is an inhibitor of Type II fatty acid synthase which is found [...] activity over TLM. In addition, some of the analogues showed activity when assayed against the parasitic protozoa, Trypanosoma cruzi and Trypanosoma brucei
Molecular assays for antimalarial drug resistance surveillance: a target product profile (Publications)
Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance following treatment with artemisinin derivatives has now spread in the Greater Mekong [...] these studies are complex and both time- and resource-intensive. For multiple common antimalarials, parasite drug resistance has been correlated with specific genetic mutations, and the molecular markers [...] drug resistance offer a simple and powerful tool to monitor the emergence and...
