Accelerating towards <em>P. vivax</em> elimination with a novel serological test-and-treat strategy: a modelling case study in Brazil (Publications)
a single MDA (25.2% [95% UI: 9.6%-42.2%] point prevalence reduction versus 34.4% [95% UI: 24.9%-44%]), PvSeroTAT requires 4.6 times less radical cure treatments and G6PD tests. Layering strengthened case [...] radical cure regimen with primaquine is predicted to reduce point population prevalence by 22.5% [95% UI: 20.2%-24.8%] in a peri-urban setting with high transmission and by 25.2% [95% UI: 9.6%-42.2%] in an o [...] prevalence by a mean of 74.1% [95% UI: 61.3%-86.3%] or more in low...
Effect of schistosomiasis on the outcome of patients infected with HIV-1 starting antiretroviral therapy in rural Tanzania (Publications)
09) after 10 months of follow-up. After adjustment for baseline risk factors, CAA-positivity showed no association with virological or immunological failure. In CAA-positive patients, 22.7% (20/88) died [...] PRINCIPAL FINDINGS: At ART-initiation 19.1% (88/461) of patients were CAA-positive. A tendency of higher CD4 increases was seen in CAA-positive patients (+182 cells/mul, interquartile range (IQR), 87-285 cells/mul) [...] showed a trend of a decreased hazard of death/LFU (HR: 0.58, 95% CI:...
Accelerating towards <em>P. vivax</em> elimination with a novel serological test-and-treat strategy: a modelling case study in Brazil (Publications)
a single MDA (25.2% [95% UI: 9.6%-42.2%] point prevalence reduction versus 34.4% [95% UI: 24.9%-44%]), PvSeroTAT requires 4.6 times less radical cure treatments and G6PD tests. Layering strengthened case [...] radical cure regimen with primaquine is predicted to reduce point population prevalence by 22.5% [95% UI: 20.2%-24.8%] in a peri-urban setting with high transmission and by 25.2% [95% UI: 9.6%-42.2%] in an o [...] prevalence by a mean of 74.1% [95% UI: 61.3%-86.3%] or more in low...
Effect of schistosomiasis on the outcome of patients infected with HIV-1 starting antiretroviral therapy in rural Tanzania (Publications)
09) after 10 months of follow-up. After adjustment for baseline risk factors, CAA-positivity showed no association with virological or immunological failure. In CAA-positive patients, 22.7% (20/88) died [...] PRINCIPAL FINDINGS: At ART-initiation 19.1% (88/461) of patients were CAA-positive. A tendency of higher CD4 increases was seen in CAA-positive patients (+182 cells/mul, interquartile range (IQR), 87-285 cells/mul) [...] showed a trend of a decreased hazard of death/LFU (HR: 0.58, 95% CI:...
Unit | Clinical Operations Over 20 Years' Experience as Clinical Trials Service Provider Swiss TPH has extensive expertise in clinical trial service provision, with a successful track record of operating [...] operating and facilitating research in resource-constraint settings for over 20 years. We understand the barriers to conducting clinical trials in difficult settings and offer strategic, customised solutions [...] based tuberculosis triage testing after symptom screening in...
2024;43(4):114012. DOI: 10.1016/j.celrep.2024.114012 Hellingman A et al. Next generation chemiluminescent probes for antimalarial drug discovery. ACS Infect Dis . 2024;10(4):1286−1297. DOI: 10.1021/acsinfecdis [...] DOI: 10.1038/s41467-025-62014-3 Bravo P et al. A novel antimalarial agent that inhibits protein synthesis in Plasmodium falciparum . Angew Chem Int Ed Engl . 2025(in press):e202514085. DOI: 10.1002/anie [...] Darif N.D et al. BioMalPar XX: looking back on, and forward from, 20 years...
Practice change needed for the identification of pediatric hypertension in marginalized populations: an example from South Africa (Publications)
Introduction:Hypertension in children has increased globally over the past 20 years; yet, little is known about this issue among disadvantaged communities from low- and middle-income countries. Age-, sex- [...] blood pressure categorization with increasing BMI levels. ResultsHypertension prevalence ranged from 11.4% with the pseudo-normative study tables to 28.8% based on the German reference. Global guidelines showed [...] global and the American references presented higher systolic over...
Malaria vectors and their blood-meal sources in an area of high bed net ownership in the western Kenya highlands (Publications)
blood-meals from humans, 26.5 % from goats and 18.4 % from bovines. Single blood-meal sources by An. gambiae s.s. from humans were 26.5 %, 8.2 % from bovines and 2.0 % from goats. Mixed blood-meal sources by An [...] An. gambiae s.s. identified included: 24.5 % human/goat, 10.2 % human/bovine, 8.2 % human/bovine/goat and also 8.2 % bovine/goat. One An. arabiensis mosquito obtained blood-meal only from humans. CONCLUSION:
Practice change needed for the identification of pediatric hypertension in marginalized populations: an example from South Africa (Publications)
Introduction:Hypertension in children has increased globally over the past 20 years; yet, little is known about this issue among disadvantaged communities from low- and middle-income countries. Age-, sex- [...] blood pressure categorization with increasing BMI levels. ResultsHypertension prevalence ranged from 11.4% with the pseudo-normative study tables to 28.8% based on the German reference. Global guidelines showed [...] global and the American references presented higher systolic over...
Malaria vectors and their blood-meal sources in an area of high bed net ownership in the western Kenya highlands (Publications)
blood-meals from humans, 26.5 % from goats and 18.4 % from bovines. Single blood-meal sources by An. gambiae s.s. from humans were 26.5 %, 8.2 % from bovines and 2.0 % from goats. Mixed blood-meal sources by An [...] An. gambiae s.s. identified included: 24.5 % human/goat, 10.2 % human/bovine, 8.2 % human/bovine/goat and also 8.2 % bovine/goat. One An. arabiensis mosquito obtained blood-meal only from humans. CONCLUSION:
