Sleeping Sickness - African Human Tryponosomiasis
African sleeping sickness can only be tackled in a combined effort. Since decades Swiss TPH has been developing unique methods aimed at studying the effect of compounds on the fatal parasites directly. In the last ten years, researchers at Swiss TPH identified several dozen highly active compounds, some with complete new properties. The most promising candidate compounds were selected for further preclinical analysis.
From Laboratory to Field
While new compounds are being sought in the laboratories, other Swiss TPH staff often find themselves dealing with the realities of everyday life in the field: clinical research in remote locations with arduous journeys, extremely limited medical care and logistical difficulties on site. Despite of all these challenges, a clinical trial must meet the highest possible standards.
Eradication West African Sleeping Sickness?
Experts of Swiss TPH have evaluated and modelled various scenarios for halting the spread of West African Sleeping Sickness. The models show that, in addition to the introduction of new drugs, tsetse fly populations should be destroyed in a targeted manner, diagnosis improved and the active monitoring of disease outbreaks reinforced.
A Swiss TPH Success Story
Fexinidazole against African Human Trypanosomiasis
Human Africa Trypanosomiasis is a life-threatening neglected disease. To date nifurtimox-eflornithine combined therapy (NECT) is the Standard Treatment for late-stage HAT. Nevertheless, NECT is still far from ideal given the environment in which HAT patients live. There is an urgent need to develop less toxic and easier-to-use products. One promising agent is Fexinidazole.
Drug Discovery in Collaboration with DNDi
The Drugs for Neglected Diseases initiative (DNDi) can be viewed as a virtual non-profit pharmaceutical company with technical support from a range of partners in industry, universities, foundations and the public sector. We collaborate with DNDi in the area of drug discovery by contributing in vitro assays for the parasites and cytotoxicity assessment as well as rodent models of infection for African trypanosomes.