In vitro assessment of the pharmacodynamic properties of DB75, piperaquine, OZ277 and OZ401 in cultures of<em> Plasmodium falciparum</em> (Publications)
cultures of Plasmodium falciparum, the time- and concentration-dependent growth changes of erythrocytic parasite stages to DB75, piperaquine, OZ277 and OZ401 were investigated in vitro over a concentration range [...] vitro exposure (1, 6, 12 or 24 h) were monitored by the incorporation of [(3)H]hypoxanthine into the parasite nucleic acids. Results After 1 h of exposure to the highest concentration of the compound followed
<em>In vitro</em> and <em>in vivo</em> trematode models for chemotherapeutic studies (Publications)
SUMMARYSchistosomiasis and food-borne trematodiases are chronic parasitic diseases affecting millions of people mostly in the developing world. Additional drugs should be developed as only few drugs are [...] are available for treatment and drug resistance might emerge. In vitro and in vivo whole parasite screens represent essential components of the trematodicidal drug discovery cascade. This review describes
Antiparasitic agents: new drugs on the horizon (Publications)
The need for new drugs against tropical parasites such as Plasmodium falciparum and Trypanosoma brucei is persistent since problems with resistance and toxicity are jeopardizing the currently available [...] diamidines, novel members of which may serve as back-up compounds against trypanosomes and other parasites. Thus, finally, new therapeutic agents against malaria and sleeping sickness are within reach
Swiss TPH Students' Global Health Endeavours Around the World | Impact Stories (Page)
https://www.swisstph.ch/en/impact-stories/swiss-tph-students-global-health-endeavours-around-the-world
Centre Suisse de Recherches Scientifiques en Côte d’Ivoire (CSRS) collected over 1,000 parasites. These parasites exhibit both drug-sensitive and non-sensitive characteristics. The purpose of this project [...] addresses the challenge of intestinal parasites that affect more than 1.5 billion people worldwide. At present, there are limited drugs available to treat these parasitic infections, and their efficacy widely [...] Lydia Trippler Lydia Trippler is dedicated to combating schistosomiasis –...
Does radical cure of asymptomatic <em>Plasmodium falciparum</em> place adults in endemic areas at increased risk of recurrent symptomatic malaria? (Publications)
cohort of 197 adults in Kassena-Nankana District (northern Ghana) was radically cured of malaria parasites to study subsequent incidence of malaria infection. During the following 20 weeks of the malaria [...] survivor functions, P=0.035). Clinical attacks in radically cured individuals presented with lower parasite densities but more symptoms. Randomized studies are needed to test the hypothesis that radical cure
Does radical cure of asymptomatic <em>Plasmodium falciparum</em> place adults in endemic areas at increased risk of recurrent symptomatic malaria? (Publications)
cohort of 197 adults in Kassena-Nankana District (northern Ghana) was radically cured of malaria parasites to study subsequent incidence of malaria infection. During the following 20 weeks of the malaria [...] survivor functions, P=0.035). Clinical attacks in radically cured individuals presented with lower parasite densities but more symptoms. Randomized studies are needed to test the hypothesis that radical cure
Optimization of Antischistosomal Chemotypes (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/optimization-of-antischistosomal-chemotypes
work is to identify one or more antischistosomal drug development candidates effective against all parasite stages and with a novel mechanism of action. Such a drug would be important in the chemotherapy [...] drug-resistant schistosomiasis and likely be valuable in integrated control programs to curb this parasitic disease.
Molecular methods for tracking residual <em>Plasmodium falciparum </em>transmission in a close-to-elimination setting in Zanzibar (Publications)
household members and neighbors of index cases was 1.7% (78/4590) with a geometric mean parasite density of 58 parasites/microl blood. Using qPCR as gold standard, diagnostic sensitivity of rapid diagnostic [...] investigated by a highly sensitive quantitative (q) PCR that targets multiple var gene copies per parasite genome. To reduce cost, a first round of positivity screening was performed on pools of dried blood [...] (RDTs) was 37% (29/78). Infections positive by qPCR but negative by RDT...
Molecular methods for tracking residual <em>Plasmodium falciparum </em>transmission in a close-to-elimination setting in Zanzibar (Publications)
household members and neighbors of index cases was 1.7% (78/4590) with a geometric mean parasite density of 58 parasites/microl blood. Using qPCR as gold standard, diagnostic sensitivity of rapid diagnostic [...] investigated by a highly sensitive quantitative (q) PCR that targets multiple var gene copies per parasite genome. To reduce cost, a first round of positivity screening was performed on pools of dried blood [...] (RDTs) was 37% (29/78). Infections positive by qPCR but negative by RDT...
The Achilles Heel of Plasmodia - Advances in Vaccine Development against Malaria (News)
https://www.swisstph.ch/en/news/news-detail/news/the-achilles-heel-of-plasmodia-advances-in-vaccine-development-against-malaria
with these precise "replicas", the immune system can develop an efficient protection against the parasites. Search for Hidden Antigens The variability of antigens is a major problem in the development of [...] strains. For this reason, they are not a suitable starting point for a vaccine. "We must recognise the parasite's Achilles heel and present it to the immune system in such a way that a strong immune response [...] part, not very variable. Thus, antibodies against them can provide...
