Activities (Page)
https://www.swisstph.ch/en/about/events/open-house-2023/activities
T-shirt*/** Bloodsuckers in Sight: What Is New in Mosquito Research?*/** Parasite Pummel: Topple the Invaders*/** Become a Parasite Hunter: Can You Find All the Worms?* Fumes, Noise and Pollen: When the [...] Ground floor Swiss TPH Shop Photobooth */** Swiss TPH Cinema: A Glimpse Into Our Work and History ** Parasite Circus*/** Pathogen Expedition: Journey through Swiss TPH's Diagnostics 80 Years of Swiss TPH: A
Design and selection of drug properties to increase the public health impact of next-generation seasonal malaria chemoprevention: a modelling study (Publications)
-pyrimethamine plus amodiaquine. However, poor regimen adherence and the increased frequency of parasite mutations conferring sulfadoxine-pyrimethamine resistance might threaten the effectiveness of SMC [...] this modelling study, we combined an individual-based malaria transmission model that has explicit parasite growth with drug pharmacokinetic and pharmacodynamic models. We modelled SMC drug attributes for [...] impact. Global sensitivity analyses identified trade-offs between drug...
Mode of action of synthetic antimalarial peroxides (Publications)
and artemisinins, both thought to have similar modes of action, is not known. Recently, prolonged parasite clearance rates in patients after treatment with artesunate or ACTs were published, indicating a [...] identify alkylation signatures in P. falciparum. Since it was not possible to identify the alkylated parasite proteins with antibodies, I set up a novel approach using click chemistry with newly synthesized [...] studies are needed to investigate if OZ439 is effective against...
Mining Sudanese medicinal plants for antiprotozoal agents (Publications)
mug/ml, and > 50% at 2 mug/ml against at least one of the protozoan parasites. Plasmodium falciparum was the most sensitive of the parasites, followed by T. b. rhodesiense and L. donovani. Only few hits were [...] and supports the notion that they are a potential source of bioactive molecules against protozoan parasites.
Mining Sudanese medicinal plants for antiprotozoal agents (Publications)
mug/ml, and > 50% at 2 mug/ml against at least one of the protozoan parasites. Plasmodium falciparum was the most sensitive of the parasites, followed by T. b. rhodesiense and L. donovani. Only few hits were [...] and supports the notion that they are a potential source of bioactive molecules against protozoan parasites.
Mode of action of synthetic antimalarial peroxides (Publications)
and artemisinins, both thought to have similar modes of action, is not known. Recently, prolonged parasite clearance rates in patients after treatment with artesunate or ACTs were published, indicating a [...] identify alkylation signatures in P. falciparum. Since it was not possible to identify the alkylated parasite proteins with antibodies, I set up a novel approach using click chemistry with newly synthesized [...] studies are needed to investigate if OZ439 is effective against...
Design and selection of drug properties to increase the public health impact of next-generation seasonal malaria chemoprevention: a modelling study (Publications)
-pyrimethamine plus amodiaquine. However, poor regimen adherence and the increased frequency of parasite mutations conferring sulfadoxine-pyrimethamine resistance might threaten the effectiveness of SMC [...] this modelling study, we combined an individual-based malaria transmission model that has explicit parasite growth with drug pharmacokinetic and pharmacodynamic models. We modelled SMC drug attributes for [...] impact. Global sensitivity analyses identified trade-offs between drug...
Chemoproteomics validates selective targeting of <em>Plasmodium</em> M1 alanyl aminopeptidase as an antimalarial strategy (Publications)
methods based on thermal stability and limited proteolysis of whole parasite lysates revealed that MIPS2673 solely targets PfA-M1 in parasites, with limited proteolysis also enabling estimation of the binding
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria (Publications)
anti-malarial activity by phenotypic screening. Selection of SW042-resistant Plasmodium falciparum (Pf) parasites revealed point mutations in the Pf_proteasome β5 active-site (Pfβ5). A potent analog (SW584) showed [...] purification was facilitated by His(8)-tag introduction onto β7. Inhibition of Pfβ5 correlated with parasite killing, without inhibiting human proteasome isoforms or showing cytotoxicity. The Pf_proteasome_SW584
Impedance-based microfluidic assay for automated antischistosomal drug screening (Publications)
Schistosomiasis is a neglected tropical disease, caused by parasitic worms, which affects almost 200 million people worldwide. For over 40 years, chemotherapeutic treatment has relied on the administration [...] of electrodes and a channel of variable geometry to enable counting and size detection of single parasite larvae and the collective evaluation of the motility of the larvae as an unbiased estimator for
