Sleeping Sickness Elimination at a Crossroads (News)
https://www.swisstph.ch/en/news/news-detail/news/sleeping-sickness-elimination-at-a-crossroads
Sleeping sickness is a vector-borne parasitic disease caused by infection with protozoan parasites belonging to the genus Trypanosoma. They are transmitted to humans by bites of tsetse flies that have [...] have been infected from humans or animals harbouring human pathogenic parasites. Tsetse flies are only found in sub-Saharan Africa; rural populations living in regions where transmission occurs and which depend
Fexinidazole - First All-Oral Treatment for Sleeping Sickness Approved (News)
https://www.swisstph.ch/en/news/news-detail/news/fexinidazole-first-all-oral-treatment-for-sleeping-sickness-approved
development of fexinidazole. The Parasite Chemotherapy Unit performed the assays necessary to identify fexinidazole as the most promising drug candidate against the Trypanosoma parasite. The Clinical Operations [...] treatment that works both for the early stage as well as the second stage of the disease in which the parasites have crossed the blood-brain barrier, causing patients to suffer from neuropsychiatric symptoms
R. Geigy Award 2022 Goes to Three Researchers for Work on Malaria and Tuberculosis Control in Africa (News)
https://www.swisstph.ch/en/news/news-detail/news/r-geigy-award-2022-goes-to-three-researchers-for-work-on-malaria-and-tuberculosis-control-in-africa
endemic areas are still affected by the deadly disease. New methods that prevent transmission of the parasite from mosquitoes to humans are urgently needed in the future if the goal of eliminating and later [...] laboratory, have established a unique research platform in Tanzania, including cell cultures of malaria parasites, which allows them to test the effect of new vaccines or drugs on malaria transmission. "If we stick [...] stick to the goal of eliminating malaria, we also need new...
Monkey malaria in a European traveler returning from Malaysia (Publications)
In 2007, a Finnish traveler was infected in Peninsular Malaysia with Plasmodium knowlesi, a parasite that usually causes malaria in monkeys. P. knowlesi has established itself as the fifth Plasmodium species
Monkey malaria in a European traveler returning from Malaysia (Publications)
In 2007, a Finnish traveler was infected in Peninsular Malaysia with Plasmodium knowlesi, a parasite that usually causes malaria in monkeys. P. knowlesi has established itself as the fifth Plasmodium species
<em>Dirofilaria repens</em> infection and concomitant meningoencephalitis (Publications)
Clinical symptoms are usually restricted to a subcutaneous nodule containing a single infertile parasite. Here, we report a case of D. repens infection with a subcutaneous gravid worm and the patient's
Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of <em>Trypanosoma cruzi </em>dUTPase (Publications)
library of amino acid uracil acetamide compounds which were evaluated for enzyme inhibition and anti-parasitic activity
Anna K. H. Hirsch: drug design and optimisation to disarm dangerous germs (Publications)
dedicated to fighting infectious diseases by focussing on enzymes that are central to the metabolism of parasites. Her research has led to a valuable collaboration with the Swiss Tropical and Public Health Institute
Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160) (Publications)
dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis
Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160) (Publications)
dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis
