Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives (Publications)
Recently, it was found that the compound is a potent in vitro and in vivo inhibitor of the protozoan parasite Trypanosoma brucei, which causes human African trypanosomiasis (HAT; sleeping sickness). In this
Investigation of thiazolyl–benzothiophenamides as potential agents for African sleeping sickness (Publications)
hput screening identified the thiazolyl–benzothiophenamide 1 to be active against the causative parasite, Trypanosoma brucei. This work establishes structure–activity relationships of 1, guiding the design
Investigation of thiazolyl–benzothiophenamides as potential agents for African sleeping sickness (Publications)
hput screening identified the thiazolyl–benzothiophenamide 1 to be active against the causative parasite, Trypanosoma brucei. This work establishes structure–activity relationships of 1, guiding the design
Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives (Publications)
Recently, it was found that the compound is a potent in vitro and in vivo inhibitor of the protozoan parasite Trypanosoma brucei, which causes human African trypanosomiasis (HAT; sleeping sickness). In this
A new chemotype with promise against <em>Trypanosoma cruzi</em> (Publications)
Pyridyl benzamide 2 is a potent inhibitor of Trypanosoma cruzi, but not other protozoan parasites, and had a selectivity-index of > /=10. The initial structure-activity relationship (SAR) indicates that
African Sleeping Sickness - Putting an End to the Fatal Disease (Page)
https://www.swisstph.ch/en/news/20160601-african-sleeping-sickness-putting-an-end-to-the-fatal-disease
unique methods aimed at studying the effect of compounds on the fatal parasites directly. “Our testing systems against the parasites that cause sleeping sickness have proven to be extremely useful and [...] new pharmaceutical compounds to economic analysis. 01.06.2016 by Christian Heuss Directorate Unit: Parasite Chemotherapy African Sleeping Sickness - Putting an End to the Fatal Disease Fexinidazole – a Compound [...] informative,” says Pascal Mäser. Fexinidazole was highly effective in the...
Prospective European-wide multicentre study on a blood based real-time PCR for the diagnosis of acute schistosomiasis (Publications)
diagnostics, an early and rapid diagnosis is required. So far, classic diagnostic tools such as parasite microscopy or serology lack considerable sensitivity at this early stage of Schistosoma infection [...] 92%). In contrast, sensitivity of serology (enzyme immunoassay and/or immunofluorescence assay) or parasite microscopy was only 70% and 24%, respectively. CONCLUSION: For the early diagnosis of acute sch
Improving methods for analysing anti-malarial drug efficacy trials: molecular correction based on length-polymorphic markers <em>msp</em>-1,... (Publications)
failures, and patients are frequently re-infected during that period. Molecular correction based on parasite genotypes distinguishes reinfections from drug failures to ensure the accuracy of failure rate estimates [...] most accurate and/or robust remains unknown. METHODS: We used pharmacological modelling to simulate parasite dynamics and genetic signals that occur in patients enrolled in malaria drug clinical trials. We
Investigating the drivers of the spatio-temporal patterns of genetic differences between <em>Plasmodium falciparum</em> malaria infections in Kilifi... (Publications)
trials to assess the interventions. A previous analysis of 1602 genotyped Plasmodium falciparum parasites in Kilifi, Kenya collected over 12 years found an interaction between time and geographic distance: [...] clearance were included. We fit the model to the observed numbers of SNP differences between pairs of parasite genotypes. The patterns observed in the empiric data could be reproduced. Although we cannot rule
Impact and cost-effectiveness of snail control to achieve disease control targets for schistosomiasis (Publications)
Schistosomiasis is a parasitic disease that affects over 240 million people globally. To improve population-level disease control, there is growing interest in adding chemical-based snail control interventions [...] interventions to interrupt the lifecycle of Schistosoma in its snail host to reduce parasite transmission. However, this approach is not widely implemented, and given environmental concerns, the optimal conditions
