Sushi delights and parasites: the risk of fishborne and foodborne parasitic zoonoses in Asia (Publications)
fishborne parasitic zoonoses, especially anisakiasis. In addition, an array of freshwater and brackish-water fish and wild animal meats, which are important sources of infection with zoonotic parasites, are [...] are served as sushi and sashimi in rural areas of Japan. Such fishborne and foodborne parasitic zoonoses are also endemic in many Asian countries that have related traditional cooking styles. Despite the [...] is to provide practical background information regarding representative...
Global impact of parasitic infections and the importance of parasite control (Publications)
Parasites have a severe impact on animal and human health. Parasites like worms, ticks, mites, fleas, biting flies, mosquitoes, and pathogenic protozoa affect humans and their pets as well as their livestock [...] infection. The effective control of parasites in animals can greatly improve their quality of life and is also beneficial for humans; this is threatened by drug-resistant parasite populations. Today's key areas [...] areas for improvement of parasite control are as follows: a)...
Incomplete<em> Plasmodium falciparum</em> growth inhibition following piperaquine treatment translates into increased parasite viability in the <em>in... (Publications)
, i.e. increased parasite growth at higher drug concentrations. However, the 50% inhibitory concentrations (IC(50)) remain relatively stable across parasite lines. Measuring parasite viability of a dr [...] Cambodian Plasmodium falciparum isolate in a parasite reduction ratio (PRR) assay helped to better understand the resistance phenotype towards PPQ. In this parasite isolate, incomplete growth inhibition translated [...] 5-fold increase in IC(50) but a dramatic decrease of parasite killing in...
Fighting parasites in a conflict torn country (Blog)
https://www.swisstph.ch/en/impact-stories/fighting-parasites-in-a-conflict-torn-place/blog-id/35
Maurice M. Nigo is the Director of the Institut Supérieur des Techniques Médicales (ISTM) in Bunia, one of the poorest provinces of the Democratic Republic of Congo (DRC). Since the 1990s, an armed co
Promising Drug Combination Treatment Against Parasitic Worm Infections (Page)
https://www.swisstph.ch/en/news/promisingdrugcombinationtreatmentagainstparasiticworminfections
Promising Drug Combination Treatment Against Parasitic Worm Infections 30.11.2021 In a Phase III clinical trial, researchers at Swiss TPH have successfully gathered encouraging data to demonstrate higher [...] investigation. “There are several possible reasons for the low efficacy; one of them might be the parasite itself. It is conceivable that strains of T. trichiura vary in different geographical settings and
Clinical Trials Completed for New Drug to Treat Parasitic Worm Infections (Page)
https://www.swisstph.ch/en/news/clinicaltrialscompletedforanewdrug
Clinical Trials Completed for a New Drug to Treat Parasitic Worm Infections in Infants 16.11.2021 The Pediatric Praziquantel Consortium completed its pivotal clinical Phase III trial of arpraziquantel [...] trials in Côte d’Ivoire and Kenya. Technician analysing stool samples from the clinical trial for parasite eggs, Homa Bay, Kenya. (Photo: Eric Huber, Swiss TPH) Today, the Pediatric Praziquantel Consortium [...] unmet needs for preschool-aged children Schistosomiasis is one of the most...
Manipulation of Human Immunity by Parasitic Worms (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/manipulation-of-human-immunity-by-parasitic-worms
Approximately ten percent of the world's population is at risk of schistosomiasis, a neglected, tropical disease caused by species of the helminth Schistosoma . For the past 40 years, control of schis
Exploring the mechanisms of heritable gene silencing and singular gene choice to understand antigenic variation in malaria parasites (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/exploring-the-mechanisms-of-heritable-gene-silencing-and-singular-gene-choice-to-understand-antigenic-variation-in-malaria-parasites
production of malaria transmission stages and in antigenic variation and immune evasion of malaria parasites. To achieve this we combine molecular and cell biology research with state-of-the-art reverse genetics
Combination Therapy to Treat Parasitic Worm Infections (Page)
https://www.swisstph.ch/en/news/20170829-combination-therapy-to-treat-parasitic-worm-infections
Combination Therapy to Treat Parasitic Worm Infections 29.08.2017 1.5 billion people worldwide are infected with soil-transmitted helminths, a parasitic worm infection. In the past, only two drugs have [...] Science Foundation. New drugs and combination treatments are urgently needed to treat parasitic worm infections. Parasitic worm infections are a major public health issue in low and middle-income countries [...] helminth (STH) infections affect 1.5 billion people globally. They are caused by...
Triple Drug Combination Shows High Activity Against Parasitic Worm Infections (Page)
https://www.swisstph.ch/en/news/20180417-triple-drug-combination
certain parasitic worm infections. The results were published today in the Lancet Infectious Diseases. The triple therapy could be a game changer in future global elimination strategies for parasitic worm [...] programmes." A centre of expertise in parasitic worm infections Swiss TPH is active in a broad range of activities related to research and control of parasitic worm infections. The work comprises basic [...] Triple Drug Combination Shows High Activity Against Parasitic Worm Infections...
