Antimalarial Drug Development (Page)
https://www.swisstph.ch/en/topics/malaria/antimalarial-drug-development
Next-Generation Interventions for Malaria Prevention Despite progress to reduce malaria burden, malaria parasites are becoming resistant to antimalarial drugs; therefore, new interventions are needed to protect [...] Institute of the Novartis Research Foundation Biomedical Primate Research Centre Involved Units Parasite Chemotherapy Unit Genotyping Clinical Immunology Medicines Development Unit
Malaria Elimination (Page)
https://www.swisstph.ch/en/topics/malaria/malaria-elimination
Malaria Elimination The malaria map is shrinking. In high burden areas malaria parasite prevalence has been reduced dramatically. Around 100 countries are now free from malaria. According to WHO estimates [...] decision-making for malaria control in Benin SNF_FP_modelling - Multi-scale mathematical modelling of parasite, drug and vaccine interactions: optimising public health and disease elimination strategies Links
Role of human Pegivirus infections in whole <em>Plasmodium falciparum </em>sporozoite vaccination and controlled human malaria infection in African... (Publications)
antibody titers quantified by ELISA, (3) asexual blood-stage parasitemia pre-patent periods and parasite multiplication rates, (4) HPgV-1 RNA levels upon asexual blood-stage parasitemia induced by CHMI [...] HPgV-1 infection did not alter PfSPZ Vaccine elicited levels of PfCSP-specific antibody responses and parasite multiplication rates. Ongoing HPgV-1 infection appears to improve to some degree protection against
Bayesian Modelling and Analysis (Page)
https://www.swisstph.ch/en/about/eph/biostatistics/bayesian-modelling-and-analysis
Group | Bayesian Modelling and Analysis Predicted Risk Map of Malaria Parasite among Children under 5 year in Nigeria Biostatistics Bayesian Modeling and Analysis Statistics in Epidemiology The Bayesian [...] malaria control interventions and climate variability on changes in the geographical distribution of parasite prevalence in Kenya between 2015 and 2020. Int J Health Geogr . 2024;23(1):22. DOI: 10.1186/s12
Fighting Schistosomiasis through Research and Interventions in Pemba (Page)
https://www.swisstph.ch/en/impact-stories/fighting-schistosomiasis-through-research-and-interventions-in-pemba-tanzania
produced by Swiss TPH and PHL-IdC provides an insight into the ongoing battle to eliminate this parasitic worm infection, featuring scientific research, interventions, and stories of those affected. In [...] In the documentary, Fatma, a resident of Pemba, shares her first-hand experience of this parasitic disease: “I have suffered from schistosomiasis in 2023, experiencing symptoms such as painful urination
Role of human Pegivirus infections in whole <em>Plasmodium falciparum </em>sporozoite vaccination and controlled human malaria infection in African... (Publications)
antibody titers quantified by ELISA, (3) asexual blood-stage parasitemia pre-patent periods and parasite multiplication rates, (4) HPgV-1 RNA levels upon asexual blood-stage parasitemia induced by CHMI [...] HPgV-1 infection did not alter PfSPZ Vaccine elicited levels of PfCSP-specific antibody responses and parasite multiplication rates. Ongoing HPgV-1 infection appears to improve to some degree protection against
Genotyping Group | Malaria Research at Swiss TPH (Page)
https://www.swisstph.ch/en/about/med/medicines-development/genotyping
genotyping methods, including microsatellites and amplicon sequencing, to improve our understanding of parasite population dynamics and current methods for distinguishing recrudescence from new infection, and [...] Swiss TPH, we support elimination efforts by using genomic and serological techniques to understand parasite reservoirs and guide the implementation of targeted elimination interventions. Services provision [...] new infection, Identification of antimalarial drug resistance markers,...
Malaria-anemia comorbidity prevalence as a measure of malaria-related deaths in sub-Saharan Africa (Publications)
was up to 3·5 times higher compared to the hazard related to Plasmodium parasitaemia only. Malaria parasite prevalence alone could not always capture a statistically important association with under-five
Predictors of residual antimalarial drugs in the blood in community surveys in Tanzania (Publications)
large scale helps ensuring appropriate use of treatments and preventing the spread of resistant parasites. We estimated the proportion of individuals in community surveys with residual antimalarials in
Elimination of schistosomiasis mekongi from endemic areas in Cambodia and the Lao People's Democratic Republic: current status and plans (Publications)
Republic and in Cambodia were first reported 50 and 60 years ago, respectively. However, the causative parasite Schistosoma mekongi was not recognized as a separate species until 1978. The infection is distributed
