Dual strategy to design new agents targeting <em>Schistosoma mansoni</em>: advancing phenotypic and <em>Sm</em>CB1 inhibitors for improved efficacy (Publications)
and optimized two lead structures from an in-house screening, with promising results against the parasitic flatworm Schistosoma mansoni and its target protease S. mansoni cathepsin B1 (SmCB1). Our correlation
Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity (Publications)
potency than the parent compound and showed moderate activity against a select number of other parasitic nematodes (including Ancylostoma, Heligmosomoides and Strongyloides species). Using TPP and in silico
Generation of aurachin derivatives by whole-cell biotransformation and evaluation of their antiprotozoal properties (Publications)
causative agent of malaria, Plasmodium spp. In this study, we show that aurachin D inhibits other parasitic protozoa as well. While aurachin D had only a modest effect on Trypanosoma brucei rhodesiense, two
<em>In vitro</em> and <em>in vivo</em> antischistosomal activity profiling and pharmacokinetics of ozonide carboxylic acids (Publications)
efficacy against both life stages together with their broad activity range against all relevant parasite species.
Pan-Africa Network for Genomic Surveillance of Poverty Related Diseases and Emerging Pathogens (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/pan-africa-network-for-genomic-surveillance-of-poverty-related-diseases-and-emerging-pathogens
infectious disease monitoring, and genomic surveillance will detect drug-resistant TB and malaria parasites. To achieve this, PANGenS will develop genomic epidemiology capacity across Africa by establishing
Malaria in Focus: From Research to Global Action | Swiss TPH Symposium (Page)
https://www.swisstph.ch/en/about/events/malaria-symposium-2025
ensure lasting progress in increasingly uncertain times. The symposium will focus on these topics: Parasite-host interaction and immunology Development of drugs, vaccines, diagnostics and vector control Malaria [...] the Stage , Manuel Hetzel, Swiss TPH 09:10 Mosquito Transmitted Blood Stage Attenuated Malaria Parasites as Experimental Vaccines , Freddy Frischknecht, University of Heidelberg, Germany 09:35 SLI Ways [...] Cells in Malaria Pre-Exposed Populations , Mathias Schmaler, Swiss TPH...
Schistosomiasis (Publications)
Schistosomiasis (bilharzia) is a neglected tropical disease caused by parasitic flatworms (blood flukes) of the genus Schistosoma, with considerable morbidity in parts of the Middle East, South America
In vivo antimalarial efficacy of Artemisia afra powder suspensions (Publications)
BACKGROUND: A global death toll of 608,000 in 2022 and emerging parasite resistance to artemisinin, the mainstay of antimalarial chemotherapy derived from the Chinese herb Artemisia annua, urge the development
Multiplex PCR for bacterial, viral and protozoal pathogens in persistent diarrhoea or persistent abdominal pain in Côte d'Ivoire, Mali and Nepal (Publications)
accuracy. In this multi-country study, we compared multiplex real-time PCR for enteric bacterial, parasitic and viral pathogens in stool samples from symptomatic patients and matched asymptomatic controls
Potential impact of climate change on schistosomiasis: a global assessment attempt (Publications)
accounted for replication and survival of the snail intermediate host as well as maturation of the parasite stage inside the snail at different ambient temperatures. The potential geographical distribution
