Gut Microbiota Influences Treatment against Parasitic Worms (News)
https://www.swisstph.ch/en/news/news-detail/news/gut-microbiota-influences-treatment-against-parasitic-worms
LMICs before treatment. A centre of expertise in parasitic worm infections Swiss TPH is a leading institution engaged in research and control of parasitic worm infections. The work encompasses basic research [...] and middle-income countries (LMICs), are infected with soil-transmitted helminths (STHs). These parasitic worm infections cause a myriad of symptoms from diarrhoea to poor cognitive development. To control
New chemical compound shows promising results against drug-resistant malaria parasites (News)
https://www.swisstph.ch/en/news/news-detail/news/new-chemical-compound-shows-promising-results-against-drug-resistant-malaria-parasites
active against sexual-stage parasites (gametocytes). Only at this stage of the life cycle are parasites infectious to mosquitoes. ACT-451840 is able to block the parasite’s transmission from humans to [...] preclinical studies, the compound proved to be active against P. falciparum and P. vivax – the parasites responsible for the deadliest forms of malaria in humans. “One of the huge advantages of ACT-451840 [...] clinical trials. Swiss TPH and other academic partners tested the compound in...
A milestone in the fight against malaria (News)
https://www.swisstph.ch/en/news/news-detail/news/a-milestone-in-the-fight-against-malaria
asexual forms would be fatal for the parasite: it has to be transmitted to the next person before the resources of its current host are exhausted. For that reason, the parasite transitions from an asexual to [...] malaria mosquito and thus ensure that the parasite is transmitted to other people. Mystery solved Scientists have been speculating for years about how the malaria parasite regulates the decision between asexual [...] in this process. The molecule helps the parasite to produce new cell...
Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in <em>Plasmodium falciparum</em> (Publications)
resistant Plasmodium parasites and block transmission of the disease. Here, we report that pantothenamide bioisosteres were active against blood-stage Plasmodium falciparum parasites and also blocked tr [...] converted pantothenamides into coenzyme A analogs that interfered with parasite acetyl-coenzyme A anabolism. Resistant parasites generated in vitro showed mutations in acetyl-coenzyme A synthetase and [...] the sensitivity of the malaria parasites to pantothenamides. These pantothenamide...
Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in <em>Plasmodium falciparum</em> (Publications)
resistant Plasmodium parasites and block transmission of the disease. Here, we report that pantothenamide bioisosteres were active against blood-stage Plasmodium falciparum parasites and also blocked tr [...] converted pantothenamides into coenzyme A analogs that interfered with parasite acetyl-coenzyme A anabolism. Resistant parasites generated in vitro showed mutations in acetyl-coenzyme A synthetase and [...] the sensitivity of the malaria parasites to pantothenamides. These pantothenamide...
Frontiers of parasitology research in the People's Republic of China: infection, diagnosis, protection and surveillance (Publications)
collection of 29 articles published in Parasites & Vectors. The research mainly stems from a research project entitled "Surveillance and diagnostic tools for major parasitic diseases in P.R. China" (grant no [...] series deals with the most important parasitic diseases in P.R. China, emphasizing Schistosoma japonicum, Plasmodium vivax and Clonorchis sinensis plus some parasites of emerging importance such as Angi [...] updating the surveillance data of parasitic infections both in human and...
Frontiers of parasitology research in the People's Republic of China: infection, diagnosis, protection and surveillance (Publications)
collection of 29 articles published in Parasites & Vectors. The research mainly stems from a research project entitled "Surveillance and diagnostic tools for major parasitic diseases in P.R. China" (grant no [...] series deals with the most important parasitic diseases in P.R. China, emphasizing Schistosoma japonicum, Plasmodium vivax and Clonorchis sinensis plus some parasites of emerging importance such as Angi [...] updating the surveillance data of parasitic infections both in human and...
Multiple-strain infections of <em>Trypanosoma brucei</em> across Africa (Publications)
becoming increasingly clear that parasitic infections frequently contain multiple strains of the same parasite species. This may have important consequences for the parasite dynamics in the host and thus [...] the parasite. Together with previous results, these findings strongly suggest that multiple-strain infections are common for this parasite and that their consequences for epidemiology and parasite evolution [...] Africa to assess the commonness of multiple-strain infections across the...
Multiple-strain infections of <em>Trypanosoma brucei</em> across Africa (Publications)
becoming increasingly clear that parasitic infections frequently contain multiple strains of the same parasite species. This may have important consequences for the parasite dynamics in the host and thus [...] the parasite. Together with previous results, these findings strongly suggest that multiple-strain infections are common for this parasite and that their consequences for epidemiology and parasite evolution [...] Africa to assess the commonness of multiple-strain infections across the...
Characterization of the small exported <em>Plasmodium falciparum</em> membrane protein SEMP1 (Publications)
number of exported parasite proteins was up-regulated in SEMP1-depleted parasites. By using Co-IP and transcriptome analysis for functional characterization of an exported parasite protein we provide a [...] the human malaria parasite Plasmodium falciparum during the blood stage of infection critically depend on extensive host cell refurbishments mediated through export of numerous parasite proteins into the [...] the host cell. The parasite-derived membranous structures called Maurer's clefts...
