Differential infectivity of Plasmodium for mosquitoes (Publications)
parallel processes in three sets of mosquito-parasite models, suggesting that parasite-vector specificity may depend on a balance between speed of parasite development versus speed of formation of the [...] Moreover, there are many other plasmodial parasites of other mammals and birds, that can infect other genera of mosquito. What determines this level of vector-parasite specificity? Malarial gametocytes, ingested
New fluorescence markers to distinguish co-infecting <em>Trypanosoma brucei</em> strains in experimental multiple infections (Publications)
important factors in disease evolution, parasite transmission dynamics, and the evolution of drug resistance. However, the distinction of co-infecting parasite genotypes and the tracking of their dynamics [...] inserted into the genome of Trypanosoma brucei to phenotypically label live parasites of all life cycle stages. If different parasite strains are labelled with different colours they can be easily distinguished [...] The use of fluorescence activated cell sorting (FACS) allowed rapid and...
Additional blood meals increase sporozoite infection in <em>Anopheles</em> mosquitoes but not <em>Plasmodium falciparum</em> genetic diversity (Publications)
impact of an additional non-infectious blood meal on parasite development. We also assess parasite genetic diversity at the blood stage level of the parasite in the human host and of the sporozoites in the [...] not substantially affect the genetic diversity of sporozoites in the mosquito. The most abundant parasite genotypes in the human blood were transmitted to mosquitoes, suggesting that there was no preferential [...] This study underlines the importance of additional mosquito blood meals...
Effects of structurally different HDAC inhibitors against <em>Trypanosoma cruzi</em>, <em>Leishmania</em>, and <em>Schistosoma mansoni</em> (Publications)
no efficacy toward all of the forms of the parasites' life cycle, and/or induction of resistance. Histone-modifying enzymes play a crucial role in parasite growth and survival; thus, the use of epigenetic [...] against all of the tested parasites, but it was too toxic against host cells, hampering further studies. The retinoic 2'-aminoanilide 8 was less potent than 4 in all parasitic assays, but as its toxicity [...] for further development. In T. cruzi, compound 3 exhibited a...
The Maurer's cleft protein MAHRP1 is essential for trafficking of PfEMP1 to the surface of <em>Plasmodium falciparum</em>-infected erythrocytes (Publications)
PfEMP1, accumulates within the parasite, is depleted from the Maurer's clefts and is not presented at the red blood cell surface. Complementation of the mutant parasites with mahrp1 led to the reappearance [...] During the intra-erythrocytic development of Plasmodium falciparum, the parasite modifies the host cell surface by exporting proteins that interact with or insert into the erythrocyte membrane. These proteins [...] cytoadherence, P. falciparum erythrocyte membrane protein 1...
The Maurer's cleft protein MAHRP1 is essential for trafficking of PfEMP1 to the surface of <em>Plasmodium falciparum</em>-infected erythrocytes (Publications)
PfEMP1, accumulates within the parasite, is depleted from the Maurer's clefts and is not presented at the red blood cell surface. Complementation of the mutant parasites with mahrp1 led to the reappearance [...] During the intra-erythrocytic development of Plasmodium falciparum, the parasite modifies the host cell surface by exporting proteins that interact with or insert into the erythrocyte membrane. These proteins [...] cytoadherence, P. falciparum erythrocyte membrane protein 1...
Effects of structurally different HDAC inhibitors against <em>Trypanosoma cruzi</em>, <em>Leishmania</em>, and <em>Schistosoma mansoni</em> (Publications)
no efficacy toward all of the forms of the parasites' life cycle, and/or induction of resistance. Histone-modifying enzymes play a crucial role in parasite growth and survival; thus, the use of epigenetic [...] against all of the tested parasites, but it was too toxic against host cells, hampering further studies. The retinoic 2'-aminoanilide 8 was less potent than 4 in all parasitic assays, but as its toxicity [...] for further development. In T. cruzi, compound 3 exhibited a...
Generating super-shedders: co-infection increases bacterial load and egg production of a gastrointestinal helminth (Publications)
alter the dynamics of single parasites. We posit that co-infection is a driver of variation in parasite establishment and growth, ultimately altering the production of parasite transmission stages. To test [...] Co-infection by multiple parasites is common within individuals. Interactions between co-infecting parasites include resource competition, direct competition and immune-mediated interactions and each are [...] polygyrus, the respiratory bacterial pathogen Bordetella bronchiseptica lux(+)...
Generating super-shedders: co-infection increases bacterial load and egg production of a gastrointestinal helminth (Publications)
alter the dynamics of single parasites. We posit that co-infection is a driver of variation in parasite establishment and growth, ultimately altering the production of parasite transmission stages. To test [...] Co-infection by multiple parasites is common within individuals. Interactions between co-infecting parasites include resource competition, direct competition and immune-mediated interactions and each are [...] polygyrus, the respiratory bacterial pathogen Bordetella bronchiseptica lux(+)...
BSc in Biology - Block Course | Study at Swiss TPH (Page)
https://www.swisstph.ch/en/study-with-us/bachelor/bsc-biology
Mäser Semester: Spring Semester Language: German Credits: 2 Course "Parasitology and Parasitism" Parasitology and Parasitism can be chosen in the first or second year of the Bachelor in Biology Curriculum of [...] individuals and society will be demonstrated. Infection biology studies life processes of parasites and consequences of parasite-host interactions. Epidemiology examines the frequencies and spread of infections [...] offering courses for the Bachelor's degree in Biology. These courses...
