A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes (Publications)
replaces the VSG coat by procyclins; these proteins do not protect the parasite from lysis by serum components. Our study exploits the parasite-specific process of differentiation from bloodstream to procyclic [...] asis (sleeping sickness) is a neglected tropical disease caused by Trypanosoma brucei spp. The parasites are transmitted by tsetse flies and adapt to their different hosts and environments by undergoing
The <em>Plasmodium falciparum</em> family of Rab GTPases (Publications)
and Schizosaccharomyces pombe and found that parasite Rabs segregate into possible functional clads. Such grouping into clads may give clues to parasite Rab function, and may shed light on P. falciparum [...] s, structure modelling and phylogenetics. These analyses led to the identification of seven new parasite Rabs. Accordingly we estimate that the P. falciparum family is made up of 11 genes. We show that [...] interaction interface. We used conserved RabF and RabSF motifs to discriminate...
Modeling and validation of environmental suitability for schistosomiasis transmission using remote sensing (Publications)
schistosomiasis. We investigated the potential of remote sensing to characterize habitat conditions of parasite and intermediate host snails and discuss the relevance for public health. METHODOLOGY: We employed [...] measurements, and ecological data to model environmental suitability for schistosomiasis-related parasite and snail species. The model was developed for Burkina Faso using a habitat suitability index (HSI) [...] analysis showed that temporal dynamic water and vegetation measures...
Modeling and validation of environmental suitability for schistosomiasis transmission using remote sensing (Publications)
schistosomiasis. We investigated the potential of remote sensing to characterize habitat conditions of parasite and intermediate host snails and discuss the relevance for public health. METHODOLOGY: We employed [...] measurements, and ecological data to model environmental suitability for schistosomiasis-related parasite and snail species. The model was developed for Burkina Faso using a habitat suitability index (HSI) [...] analysis showed that temporal dynamic water and vegetation measures...
The <em>Plasmodium falciparum</em> family of Rab GTPases (Publications)
and Schizosaccharomyces pombe and found that parasite Rabs segregate into possible functional clads. Such grouping into clads may give clues to parasite Rab function, and may shed light on P. falciparum [...] s, structure modelling and phylogenetics. These analyses led to the identification of seven new parasite Rabs. Accordingly we estimate that the P. falciparum family is made up of 11 genes. We show that [...] interaction interface. We used conserved RabF and RabSF motifs to discriminate...
Asymptomatic malaria infections: detectability, transmissibility and public health relevance (Publications)
and the absence of clinical symptoms. Molecular diagnostics have shown that this asymptomatic parasitic reservoir is more widespread than previously thought, even in low-endemic areas. In this Opinion [...] detectability of asymptomatic malaria infections and the relevance of submicroscopic infections for parasite transmission to mosquitoes and for community interventions that aim at reducing transmission. We
First case of ivermectin-induced severe hepatitis (Publications)
Loiasis, caused by the filarial parasite Loa loa, is endemic in West and Central Africa. Ivermectin has been shown to be an effective treatment of loiasis. We report the case of a 20-year-old woman originally [...] originally from Cameroon who was infected by the L. loa parasite and developed severe hepatitis, identified 1 month after a single dose of ivermectin. Liver biopsy showed intralobular inflammatory infiltrates
Christian Scheurer (People)
https://www.swisstph.ch/en/staff/profile/people/christian-scheurer
teaching Representation of the Zentrallabor, maintenance of various parasite cycles Past professional activities 1999 to present Parasite Chemotherapy at the Swiss Tropical Institute, Basel, Switzerland 1997
First case of ivermectin-induced severe hepatitis (Publications)
Loiasis, caused by the filarial parasite Loa loa, is endemic in West and Central Africa. Ivermectin has been shown to be an effective treatment of loiasis. We report the case of a 20-year-old woman originally [...] originally from Cameroon who was infected by the L. loa parasite and developed severe hepatitis, identified 1 month after a single dose of ivermectin. Liver biopsy showed intralobular inflammatory infiltrates
Asymptomatic malaria infections: detectability, transmissibility and public health relevance (Publications)
and the absence of clinical symptoms. Molecular diagnostics have shown that this asymptomatic parasitic reservoir is more widespread than previously thought, even in low-endemic areas. In this Opinion [...] detectability of asymptomatic malaria infections and the relevance of submicroscopic infections for parasite transmission to mosquitoes and for community interventions that aim at reducing transmission. We
