Unit | Chronic Disease Epidemiology
The Swiss study on Air Pollution And Lung Disease in Adults (SAPALDIA) is the only Swiss-wide chronic disease cohort with associated biobank. It was initiated in 1991 an dhas since been funded by the SNF, the Federal Offices for the Environment and Public Health, different Lung Leagues and cantons. SAPALDIA is at the center of national and international air pollution (ESCAPE; Exposomics) and respiratory health research (ALEC). The rich risk factor, environmental and health data as well as the genome- and methylome-wide data is used in studies ranging from assessing the role of physical activity, sleep, and transportation noise in cardio-metabolic disease etiology to the evaluation of chronic disease diagnosis and treatment.
ALEC - Aging Lungs in European Cohorts
The Horizon 2020 funded project ALEC - Aging Lungs in European Cohorts - integrates data from long-term studies with high quality spirometry data from different countries and age groups. It aims to close the gaps in understanding of poor lung function and COPD and will develop a COPD risk prediction tool. Swiss TPH is participating to ALEC with the SAPALDIA cohort and is leading the work package on genetics and epigenetics. These biomarkers are integrated into Mendelian randomization studies to interrogate the causality of COPD risk factors.
HBM4EU - The European Human Biomonitoring Initiative
Citizens are exposed to a wide range of chemicals through their diet, environment and use of consumer products. Human biomonitoring data of nationally representative or vulnerable subgroups of the population is essential to guide policy in all sectors dealing with the regulation of chemicals. Swiss TPH coordinates the participation of Switzerland in the Horizon2020 funded European Human Biomonitoring Initiative (HBM4EU). HBM4EU aims to use existing and collect new harmonized HBM data for improved understanding of health risks.
Memberships in Expert Comittees
Expert Commission for Genetic Testing in Humans
The Unit Head Nicole Probst-Hensch is member of the expert commission for Genetic Testing in Humans (GUMEK). The commission is appointed by the Federal Council for expert advise. The commission pursuits scientific and practical developments in the field of human genetics, formulates recommendations and indicates problems and gaps in the legislation.
Federal Commission for Air Hygiene
Since 2012 Nino Künzli has been the president of the Federal Commission for Air Hygiene (FCAH) that is a committee of experts in the field of air pollution control. As an extra-parliamentary committee of experts, it is appointed by the federal government. It advises the government on scientific and methodological questions relating to air pollution.
Selected ProjectsAll Projects
Latest PublicationsAll Publications
Gorski M et al. 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Sci Rep. 2017;7:45040. DOI: 10.1038/srep45040
Thurston G.D et al. A joint ERS/ATS policy statement: what constitutes an adverse health effect of air pollution? An analytical framework. Eur Respir J. 2017;49:1600419. DOI: 10.1183/13993003.00419-2016
Manning A et al. A low-frequency inactivating akt2 variant enriched in the finnish population is associated with fasting insulin levels and type 2 diabetes risk. Diabetes. 2017;66(7):2019-2032. DOI: 10.2337/db16-1329
Htun N.S.N, Probst-Hensch N, Daubenberger C, Odermatt P. A systematic review of the diseases interaction between helminthic infections and diabetic mellitus. Ann Glob Health, 2017;83(1):84. DOI: 10.1016/j.aogh.2017.03.185
Ekström M et al. Absolute values of lung function explain the sex difference in breathlessness in the general population. Eur Respir J. 2017;49(5):1602047. DOI: 10.1183/13993003.02047-2016