Group | Genetic Epidemiology of Non-Communicable Diseases

The group has established one of the largest chronic disease-related biobanks in Switzerland (The SAPALDIA Biobank). The biobank allows for studies on the genetic background of complex chronic diseases and related subclincial phenotypes, with a special focus on phenotypes related to respiratory and cardiovascular health (i.e. lung function, asthma, COPD, heart rate variability, intima-media thickness and renal function).

In the context of international collaborations and genetics consortia, staff members contribute to and lead large meta-analyses to identify novel disease genes and to understand how they modify susceptibility to lifestyle and environmental factors. Studies on the interaction of inherited genetic and epigenetic susceptibility factors with environmental factors, such as air pollution and noise, are a major focus of the group.

Nicole Probst-Hensch

Nicole Probst-Hensch, Professor, PhD (Pharmacy and Epidemiology), MPH

Australian Asthma Genetics Consortium Collaborators et al. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018;50(1):42-53. (AAGC). DOI: 10.1038/s41588-017-0014-7

Beckmeyer-Borowko A et al. SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts. Respir Res. 2018;19(1):156. DOI: 10.1186/s12931-018-0850-8

Boillat Blanco N et al. Hyperglycaemia is inversely correlated with live M. bovis BCG-specific CD4+ T cell responses in Tanzanian adults with latent or active tuberculosis. Immun Inflamm Dis. 2018;6(2):345-353. DOI: 10.1002/iid3.222

Bringolf-Isler B et al. Sedentary behaviour in Swiss children and adolescents: disentangling associations with the perceived and objectively measured environment. Int J Environ Res Public Health. 2018;15(5):918. DOI: 10.3390/ijerph15050918

Bringolf-Isler B, Schindler C, Kayser B, Suggs L.S, Probst-Hensch N, Sophya Study Group. Objectively measured physical activity in population-representative parent-child pairs: parental modelling matters and is context-specific. BMC Public Health. 2018;18:1024. DOI: 10.1186/s12889-018-5949-9