Group | Genetic Epidemiology of Non-Communicable Diseases

The group has established one of the largest chronic disease-related biobanks in Switzerland (The SAPALDIA Biobank). The biobank allows for studies on the genetic background of complex chronic diseases and related subclincial phenotypes, with a special focus on phenotypes related to respiratory and cardiovascular health (i.e. lung function, asthma, COPD, heart rate variability, intima-media thickness and renal function).

In the context of international collaborations and genetics consortia, staff members contribute to and lead large meta-analyses to identify novel disease genes and to understand how they modify susceptibility to lifestyle and environmental factors. Studies on the interaction of inherited genetic and epigenetic susceptibility factors with environmental factors, such as air pollution and noise, are a major focus of the group.

Nicole Probst-Hensch

Nicole Probst-Hensch, Professor, PhD (Pharmacy and Epidemiology), MPH

Bringolf-Isler B et al. Association of objectively measured and perceived environment with accelerometer-based physical activity and cycling: a Swiss population-based cross-sectional study of children. Int J Public Health. 2019(in press). DOI: 10.1007/s00038-019-01206-3

Brink M et al. A survey on exposure-response relationships for road, rail, and aircraft noise annoyance: differences between continuous and intermittent noise. Environ Int. 2019;125:277-290. DOI: 10.1016/j.envint.2019.01.043

Carsin A.E et al. Restrictive spirometry pattern is associated with low physical activity levels. A population based international study. Respir Med. 2019;146:116-123. DOI: 10.1016/j.rmed.2018.11.017

Hansen S et al. Gender differences in the association between life history of body silhouettes and asthma incidence: results from the SAPALDIA cohort study. Respir Med X. 2019;1:100001. DOI: 10.1016/j.yrmex.2019.100001

Lytras T et al. Occupational exposures and incidence of chronic bronchitis and related symptoms over two decades: the European Community Respiratory Health Survey. Occup Environ Med. 2019(in press). DOI: 10.1136/oemed-2018-105274