Group | Genetic Epidemiology of Non-Communicable Diseases

The group has established one of the largest chronic disease-related biobanks in Switzerland (The SAPALDIA Biobank). The biobank allows for studies on the genetic background of complex chronic diseases and related subclincial phenotypes, with a special focus on phenotypes related to respiratory and cardiovascular health (i.e. lung function, asthma, COPD, heart rate variability, intima-media thickness and renal function).

In the context of international collaborations and genetics consortia, staff members contribute to and lead large meta-analyses to identify novel disease genes and to understand how they modify susceptibility to lifestyle and environmental factors. Studies on the interaction of inherited genetic and epigenetic susceptibility factors with environmental factors, such as air pollution and noise, are a major focus of the group.

Nicole Probst-Hensch

Nicole Probst-Hensch, Professor, PhD (Pharmacy and Epidemiology), MPH

Accordini S et al. Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study. Sci Rep. 2020;10:3452. DOI: 10.1038/s41598-020-60478-5

Castro A et al. Comparing the lung cancer burden of ambient particulate matter using scenarios of air quality standards versus acceptable risk levels. Int J Public Health. 2020;65(2):139-148. DOI: 10.1007/s00038-019-01324-y

Demetz E et al. The haemochromatosis gene Hfe and Kupffer cells control LDL cholesterol homeostasis and impact on atherosclerosis development. Eur Heart J. 2020(in press). DOI: 10.1093/eurheartj/ehaa140

Gerber M et al. Effects of school-based physical activity and multi-micronutrient supplementation intervention on growth, health and well-being of schoolchildren in three African countries: the KaziAfya cluster randomised controlled trial protocol with a 2 x 2 f. Trials. 2020;21:22. DOI: 10.1186/s13063-019-3883-5

Herrmann C et al. Regional differences and trends in breast cancer surgical procedures and their relation to socioeconomic disparities and screening patterns. J Publ Health. 2020;28(1):71-80. DOI: 10.1007/s10389-018-01007-7