Medical Parasitology and Infection Biology

Research on Pathogen Biology, Host-Pathogen Interaction and Immunity

In the Department of Medical Parasitology and Infection Biology, we explore the molecular and cellular mechanisms underlying pathogen survival, transmission and host-pathogen interaction. We investigate how host factors influence the response to infection and disease using various models of infection as well as clinical samples from human patients. By improving our understanding of these biological processes, we hope to contribute to the control of diseases of poverty such as malaria, tuberculosis, trypanosomiasis, dengue, Buruli ulcer and helminth infections.

Research on Pathogen Evolution and Transmission

We study how pathogens evolve to evade host immune mechanisms and develop resistance to anti-microbials, and how these phenomena influence the spread of these microbes. We apply various molecular epidemiological approaches to analyze infection and transmission dynamics, and monitor the effects of interventions such as transmission control, vaccination or drug treatment on the prevalence and population structure of these pathogens.

Development of Diagnostics, Drugs and Vaccines

We use our enhanced understanding of host-pathogen biology to develop new diagnostics, drug sensitivity assays, drugs and vaccines against these diseases. We evaluate new diagnostics, and perform both pre-clinical and clinical studies of novel treatments as well as of candidate antigens and antigen delivery systems for vaccine purposes. This work also includes the development of new animal models and controlled human infection models to assess novel interventions. These activities are carried it out in collaboration with many international institutions, including our long-term partners in endemic countries.

 

Sébastien Gagneux

Coulibaly J.T et al. High sensitivity of mobile phone microscopy screening for Schistosoma haematobium in Azaguié, Côte d'Ivoire. Am J Trop Med Hyg. 2023;108(1):41-43. DOI: 10.4269/ajtmh.22-0527

Daubenberger C. Genetically modified malaria parasites as vaccine candidates. Trends Mol Med. 2023;29(1):1-3. DOI: 10.1016/j.molmed.2022.11.005

Kruth S et al. Generation of aurachin derivatives by whole-cell biotransformation and evaluation of their antiprotozoal properties. Molecules. 2023;28:1066. DOI: 10.3390/molecules28031

White R et al. Special considerations for studies of extracellular vesicles from parasitic helminths: a community-led roadmap to increase rigour and reproducibility. J Extracell Vesicles. 2023;12:e12298. DOI: 10.1002/jev2.12298

Albisetti A, Venugopal K, Guérin A. New frontiers in host-parasite interactions, from cell to organism. Mol Microbiol. 2022(in press). DOI: 10.1111/mmi.15013