Unit | Health Interventions

The Health Interventions Unit deals with the development and field testing of new health interventions, with a strong focus on malaria. We operate a dual portfolio of service projects and research studies in a number of countries in Africa South of the Sahara (chiefly Tanzania, Ivory Coast and Democratic Republic of Congo) and in Papua New Guinea. Because of the very applied nature of our work, we collaborate extensively with the service departments in the institute. We also interact regularly with the Health Systems Research and Dynamical Modelling Unit, as well as with the Medical Parasitology and Infection Biology (MPI) research groups.

Research

Research work deals with the integration of new interventions into the health system (for example injectable or rectal artesunate for the treatment of severe malaria), doing trials of new vaccine candidates, developing new treatment algorithms for children with fever, improving the monitoring and evaluation of national programmes, and finally developing new vector control tools and testing them in the field. All groups also aim to strengthen capacity in malaria-endemic countries on the basis of institutional collaborative arrangements and formal training courses.

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Selected projects at this location:

Bretscher M. T et al. The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data. BMC Med. 2020;18:47. DOI: 10.1186/s12916-020-1494-3

Gallay J et al. Corrigendum to "LC-MS/MS method for the simultaneous analysis of seven antimalarials and two active metabolites in dried blood spots for applications in field trials: Analytical and clinical validation" [J. Pharm. Biomed. Anal. 154 (2018) 263-277]. J Pharm Biomed Anal. 2020;182:112759. DOI: 10.1016/j.jpba.2019.07.007

Guirou E.A et al. Molecular malaria surveillance using a novel protocol for extraction and analysis of nucleic acids retained on used rapid diagnostic tests. medRxiv. 2020(in press). DOI: 10.1101/2020.02.17.20023960

Musa J. J et al. Long-lasting insecticidal nets retain bio-efficacy after 5 years of storage: implications for malaria control programmes. Malar J. 2020;19:110. DOI: 10.1186/s12936-020-03183-y

N'Dri B. P et al. Use of insecticides in agriculture and the prevention of vector-borne diseases: Population knowledge, attitudes, practices and beliefs in Elibou, South Cote d'Ivoire. Trop Med Infect Dis. 2020;5:36. DOI: 10.3390/tropicalmed5010036