Unit | Clinical Immunology

Our group focuses on systems-immunology-based approaches within the framework of Phase I to III clinical trials. We aim to identify surrogates of protection as well as host factors elicited by subunit and whole parasite vaccines against tuberculosis (TB) and malaria. Clinical trials are performed with our partners of the Ifakara Health Institute in Bagamoyo. Further, the unit develops novel diagnostic tools for paediatric clinical TB in high endemic countries.

Co-Morbidity

Co-morbidity studies analyse the impact of non-communicable diseases on immune responses against infectious diseases, particularly TB. Unit researchers also work to understand the consequences of helminth co-infections on malaria, TB and HIV pathogenesis and immunity.

Cornick J.E et al. The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pneumoniae serotype 1. Vaccine. 2017;35(6):972-980. DOI: 10.1016/j.vaccine.2016.12.037

Gotia H.T, Munro J.B, Knowles D.P, Daubenberger C.A, Bishop R.P, Silva J.C. Absolute quantification of the host-to-parasite DNA ratio in Theileria parva-infected lymphocyte cell lines. PLoS One. 2016;11(3):e0150401. DOI: 10.1371/journal.pone.0150401

Olds C.L, Mwaura S, Odongo D.O, Scoles G.A, Bishop R, Daubenberger C. Induction of humoral immune response to multiple recombinant Rhipicephalus appendiculatus antigens and their effect on tick feeding success and pathogen transmission. Parasit Vectors. 2016;9:484. DOI: 10.1186/s13071-016-1774-0

Lenz N et al. Antiviral innate immune activation in HIV infected adults negatively affects H1/IC31(R) induced vaccine-specific memory CD4+ T cells. Clin Vaccine Immunol. 2015;22(7):688-696. DOI: 10.1128/CVI.00092-15

Webster B.L et al. Development of novel multiplex microsatellite polymerase chain reactions to enable high-throughput population genetic studies of Schistosoma haematobium. Parasit Vectors. 2015;8:432. DOI: 10.1186/s13071-015-1044-6