Unit | Clinical Immunology

Our group focuses on systems-immunology-based approaches within the framework of Phase I to III clinical trials. We aim to identify surrogates of protection as well as host factors elicited by subunit and whole parasite vaccines against tuberculosis (TB) and malaria. Clinical trials are performed with our partners of the Ifakara Health Institute in Bagamoyo. Further, the unit develops novel diagnostic tools for paediatric clinical TB in high endemic countries.

Co-Morbidity

Co-morbidity studies analyse the impact of non-communicable diseases on immune responses against infectious diseases, particularly TB. Unit researchers also work to understand the consequences of helminth co-infections on malaria, TB and HIV pathogenesis and immunity.

Daubenberger C.A. Towards protective immune responses against malaria in pregnant women. Lancet Infect Dis. 2020(in press). DOI: 10.1016/S1473-3099(20)30002-5

Geiger K.M et al. Epitope mapping and fine specificity of human T and B cell responses for novel candidate blood-stage malaria vaccine P27A. Front Immunol. 2020;11:412. DOI: 10.3389/fimmu.2020.00412

Guirou E.A et al. Molecular malaria surveillance using a novel protocol for extraction and analysis of nucleic acids retained on used rapid diagnostic tests. medRxiv. 2020(in press). DOI: 10.1101/2020.02.17.20023960

Hill D.L et al. Immune system development varies according to age, location, and anemia in African children. Sci Transl Med. 2020;12(529):eaaw9522. DOI: 10.1126/scitranslmed.aaw9522

Krähenbühl S et al. ELIMU-MDx: a web-based, open-source platform for storage, management and analysis of diagnostic qPCR data. Biotechniques. 2020;68(1):22-27. DOI: 10.2144/btn-2019-0064