P. falciparum Malaria: Developing a Synthetic Subunit Candidate Vaccine

Malaria is one of the most serious infectious diseases of humans, infecting 5–10% of the world’s population, with 300–600 million clinical cases and more than 2 million deaths annually. Moreover, malaria is a major social and economic burden in endemic areas. In recent years, malaria has spread at an alarming rate owing to the increasing resistance of the parasite to drugs, and the resistance of mosquitoes to insecticides. Therefore, new approaches to combat malaria are urgently needed, and a vaccine is predicted to have the greatest impact in addition to being the most cost-effective control measure.


Vaccine Development

One approach is to design a subunit vaccine that incorporates several malaria protein antigens for which there is evidence of protective immunity from epidemiological data or experimental animal challenge models. Development of such subunit vaccines is critically dependent on the availability of an antigen delivery system to drive suitable protein antigen-specific immune responses in humans. Vaccine formulations have to be highly effective, human-compatible and safe. Production of synthetic or recombinant proteins that stably mimic the native structure of the corresponding malaria antigens to induce effective humoral immune responses is a further major challenge.

Our research

We are addressing both problems by developing synthetic peptide structures that induce cross-reactive antibodies against the parent malaria proteins and by coupling them to the surface of immunopotentiating reconstituted influenza virosomes (IRIVs). In addition we are evaluating the use of so fare uncharacterized predicted proteins of Plasmodium falciparum as potential new candidate vaccine antigens.

Abidi S.K et al. An individual patient data meta-analysis to estimate the diagnostic accuracy of a machine learning-based software for analyzing chest x-rays of persons with symptoms of pulmonary tuberculosis: preliminary findings. Am J Respir Crit Care Med, 2019;199:A5167

Ahoua A.R.C et al. Anti-inflammatory and quinone reductase-inducing compounds from Beilschmiedia mannii. Planta Med. 2019;85(5):379-384. DOI: 10.1055/a-0798-3155

Albertini B et al. Combining mechanochemistry and spray congealing for new praziquantel pediatric formulations in schistosomiasis treatment. Int J Mol Sci. 2019;20(5):1233. DOI: 10.3390/ijms20051233

Albrecht S et al. Age-related comorbidities and mortality in people living with HIV in rural Tanzania: data from a prospective cohort study. AIDS. 2019(in press). DOI: 10.1097/QAD.0000000000002171

Ali A.M. Population pharmacokinetic modelling and simulation of antimalaria drugs to optimize dosing in neglected populations. Basel: Univ. Basel, 2019. PhD Thesis, University of Basel, Faculty of Science

Allabadi H et al. Depression and anxiety symptoms in cardiac patients: a cross-sectional hospital-based study in a Palestinian population. BMC Public Health. 2019;19:232. DOI: 10.1186/s12889-019-6561-3

Amelio P et al. HIV infection functionally impairs Mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses. J Virol. 2019;93(5):e01728-18. DOI: 10.1128/JVI.01728-18

Ames H.M.R, Zuske M, King J.D, Steinmann P, Bosch-Capblanch X. Community and drug distributor perceptions and experiences of mass drug administration for the elimination of lymphatic filariasis: a rapid review of qualitative research. Adv Parasitol. 2019;103:117-149. DOI: 10.1016/bs.apar.2018.09.003

Aminzadeh R et al. The effect of antenna polarization and body morphology on the measurement uncertainty of a wearable multi-band distributed exposure meter. Ann Telecomm. 2019;74(1-2):67-77. DOI: 10.1007/s12243-018-0691-y

Antoine-Moussiaux N et al. The good, the bad and the ugly: framing debates on nature in a One Health community. Sustain Sci. 2019(in press). DOI: 10.1007/s11625-019-00674-z