Publications
Bresser M, Erhardt R.M, Shanaube K, Simwinga M, Mahlatsi P.A, Belus J, Schaap A, Amstutz A, Gachie T, Glass T.R, Kangololo B, Mota J, Floyd S, Katende B, Klinkenberg E, Ayles H, Reither K, Ruperez M. Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia. PLoS One. 2024;19(2):e0280105. DOI: 10.1371/journal.pone.0280105
Hiza H, Zwyer M, Hella J, Arbués A, Sasamalo M, Borrell S, Xu Z.M, Ross A, Brites D, Fellay J, Reither K, Gagneux S, Portevin D. Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania. Sci Rep. 2024;14(1):9287. DOI: 10.1038/s41598-024-60001-0
Tschan Y, Sasamalo M, Hiza H, Fellay J, Gagneux S, Reither K, Hella J, Portevin D. Diagnostic accuracy of a sequence-specific Mtb-DNA hybridization assay in urine: a case-control study including subclinical TB cases. Microbiol Spectr. 2024(in press). DOI: 10.1128/spectrum.00426-24
Vanobberghen F, Keter A.K, Jacobs B.K.M, Glass T.R, Lynen L, Law I, Murphy K, van Ginneken B, Ayakaka I, van Heerden A, Maama L, Reither K. Computer-aided detection thresholds for digital chest radiography interpretation in tuberculosis diagnostic algorithms. ERJ Open Res. 2024;10. DOI: 10.1183/23120541.00508-2023
Gils T, Kamele M, Madonsela T, Bosman S, Ngubane T, Joseph P, Reither K, Bresser M, Vlieghe E, Decroo T, Ayakaka I, Lynen L, Van Heerden A. Implementation of the advanced HIV disease care package with point-of-care CD4 testing during tuberculosis case finding: a mixed-methods evaluation. PLoS One. 2023;18(12):e0296197. DOI: 10.1371/journal.pone.0296197
Glaser N, Bosman S, Madonsela T, van Heerden A, Mashaete K, Katende B, Ayakaka I, Murphy K, Signorell A, Lynen L, Bremerich J, Reither K. Incidental radiological findings during clinical tuberculosis screening in Lesotho and South Africa: a case series. J Med Case Rep. 2023;17(1):365. DOI: 10.1186/s13256-023-04097-4
Katende B, Bresser M, Kamele M, Chere L, Tlahali M, Erhardt R.M, Muhairwe J, Ayakaka I, Glass T.R, Ruhwald M, van Ginneken B, Murphy K, de Vos M, Amstutz A, Mareka M, Mooko S.M, Reither K, González Fernández L. Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho. PLOS Glob Public Health. 2023;3(8):e0001488. DOI: 10.1371/journal.pgph.0001488
Keter A.K, Lynen L, Van Heerden A, Wong E, Reither K, Goetghebeur E, Jacobs B.K.M. Evaluation of tuberculosis diagnostic test accuracy using Bayesian latent class analysis in the presence of conditional dependence between the diagnostic tests used in a community-based tuberculosis screening study. PLoS One. 2023;18(3):e0282417. DOI: 10.1371/journal.pone.0282417
Klinkenberg E, Katende B, Ruperez M, Bresser M, Kangololo B, Bwalya J, Erhardt R.M, Schaap A, Kasese N, Gatchie T, Floyd S, Mota J, Ayles H, Shanaube K, Reither K. Creating access to SARS-CoV-2 screening and testing through community-based COVID-19 case-finding, observations from cross-sectional studies in Lesotho and Zambia. BMC Public Health. 2023;23:1414. DOI: 10.1186/s12889-023-16306-2
Labhardt N.D, González Fernández L, Katende B, Muhairwe J, Bresser M, Amstutz A, Glass T.R, Ruhwald M, Sacks J.A, Escadafal C, Mareka M, Mooko S.M, de Vos M, Reither K. Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho. PLoS One. 2023;18(3):e0278653. DOI: 10.1371/journal.pone.0278653
Loiseau C, Windels E.M, Gygli S.M, Jugheli L, Maghradze N, Brites D, Ross A, Goig G, Reinhard M, Borrell S, Trauner A, Dötsch A, Aspindzelashvili R, Denes R, Reither K, Beisel C, Tukvadze N, Avaliani Z, Stadler T, Gagneux S. The relative transmission fitness of multidrug-resistant Mycobacterium tuberculosis in a drug resistance hotspot. Nat Commun. 2023;14:1988. DOI: 10.1038/s41467-023-37719-y
Murphy K, Muhairwe J, Schalekamp S, van Ginneken B, Ayakaka I, Mashaete K, Katende B, van Heerden A, Bosman S, Madonsela T, González Fernández L, Signorell A, Bresser M, Reither K, Glass T.R. COVID-19 screening in low resource settings using artificial intelligence for chest radiographs and point-of-care blood tests. Sci Rep. 2023;13:19692. DOI: 10.1038/s41598-023-46461-w
Ndege R, Ngome O, Vanobberghen F, Bani F, Temba Y, Wilson H, Hella J, Gingo W, Sasamalo M, Mnzava D, Kimera N, Hiza H, Wigayi J, Mapesi H, Kato I.B, Mhimbira F, Reither K, Battegay M, Paris D.H, Weisser M, Rohacek M. Ultrasononography in managing extrapulmonary tuberculosis: a randomized, controlled, parallel, superiority, open-label trial. Clin Infect Dis. 2023;76(6):1013-1021. DOI: 10.1093/cid/ciac871
Nooh F, Chernet A, Reither K, Okuma J, Brattig N.W, Utzinger J, Probst-Hensch N, Paris D.H, Dreyfus A. Prevalence of fever of unidentified aetiology in East African adolescents and adults: a systematic review and meta-analysis. Infect Dis Poverty. 2023;12:55. DOI: 10.1186/s40249-023-01105-z
Ntinginya N.E, Bakuli A, Mapamba D, Sabiiti W, Kibiki G, Minja L.T, Kuchaka D, Reither K, Phillips P.P.J, Boeree M.J, Gillespie S.H, Hoelscher M, Heinrich N. Tuberculosis molecular bacterial load assay reveals early delayed bacterial killing in patients with relapse. Clin Infect Dis. 2023;76(3):e990-e994. DOI: 10.1093/cid/ciac445
Simwinga M, Mahlatsi P.A, Molale M, Witola G, Mshanga I, Katende B, Amstutz A, Reither K, Shanaube K, Motlomelo M, Bond V, Belus J.M. Facilitators and barriers to COVID-19 testing in community and clinical settings: lessons learned from Lesotho and Zambia. PLOS Glob Public Health. 2023;3(10):e0002430. DOI: 10.1371/journal.pgph.0002430
Zwyer M, Rutaihwa L.K, Windels E, Hella J, Menardo F, Sasamalo M, Sommer G, Schmülling L, Borrell S, Reinhard M, Dötsch A, Hiza H, Stritt C, Sikalengo G, Fenner L, De Jong B.C, Kato-Maeda M, Jugheli L, Ernst J.D, Niemann S, Jeljeli L, Ballif M, Egger M, Rakotosamimanana N, Yeboah-Manu D, Asare P, Malla B, Dou H.Y, Zetola N, Wilkinson R.J, Cox H, Carter E.J, Gnokoro J, Yotebieng M, Gotuzzo E, Abimiku A, Avihingsanon A, Xu Z.M, Fellay J, Portevin D, Reither K, Stadler T, Gagneux S, Brites D. Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania. PLoS Pathog. 2023;19(4):e1010893. DOI: 10.1371/journal.ppat.1010893
Gils T, Lynen L, Muhairwe J, Mashaete K, Lejone T.I, Joseph P, Ngubane T, Keter A.K, Reither K, van Heerden A. Feasibility of implementing the advanced HIV disease care package as part of community-based HIV/TB activities: a mixed-methods study protocol. BMJ Open. 2022;12(2):e057291. DOI: 10.1136/bmjopen-2021-057291
Hiza H, Hella J, Arbués A, Sasamalo M, Misana V, Fellay J, Gagneux S, Reither K, Portevin D. CD38 expression by antigen-specific CD4 t cells is significantly restored 5 months after treatment initiation independently of sputum bacterial load at the time of tuberculosis diagnosis. Front Med. 2022;9:821776. DOI: 10.3389/fmed.2022.821776
Katende B, González Fernández L, Muhairwe J, Glass T.R, Ayakaka I, Labhardt N.D, Ruhwald M, de Vos M, Bresser M, Reither K. Diagnosis of SARS-CoV-2 infection from breath: a proof-of-concept study. IJID Reg. 2022;5:163-164. DOI: 10.1016/j.ijregi.2022.10.007
Tavaziva G, Harris M, Abidi S.K, Geric C, Breuninger M, Dheda K, Esmail A, Muyoyeta M, Reither K, Majidulla A, Khan A.J, Campbell J.R, David P.M, Denkinger C, Miller C, Nathavitharana R, Pai M, Benedetti A, Khan F.A. Chest X-ray analysis with deep learning-based software as a triage test for pulmonary tuberculosis: an individual patient data meta-analysis of diagnostic accuracy. Clin Infect Dis. 2022;74(8):1390–1400. DOI: 10.1093/cid/ciab639
Xu Z.M, Rüeger S, Zwyer M, Brites D, Hiza H, Reinhard M, Rutaihwa L, Borrell S, Isihaka F, Temba H, Maroa T, Naftari R, Hella J, Sasamalo M, Reither K, Portevin D, Gagneux S, Fellay J. Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations. PLoS Comput Biol. 2022;18(1):e1009628. DOI: 10.1371/journal.pcbi.1009628
Zoller T, Mfinanga E.H, Zumba T.B, Asilia P.J, Mutabazi E.M, Wimmersberger D, Mhimbira F, Haraka F, Reither K. Symptoms and functional limitations related to respiratory health and carbon monoxide poisoning in Tanzania: a cross sectional study. Environ Health. 2022;21:38. DOI: 10.1186/s12940-022-00847-x
Gygli S.M, Loiseau C, Jugheli L, Adamia N, Trauner A, Reinhard M, Ross A, Borrell S, Aspindzelashvili R, Maghradze N, Reither K, Beisel C, Tukvadze N, Avaliani Z, Gagneux S. Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis. Nat Med. 2021;27:1171–1177. DOI: 10.1038/s41591-021-01358-x
Gygli S.M, Loiseau C, Jugheli L, Adamia N, Trauner A, Reinhard M, Ross A, Borrell S, Aspindzelashvili R, Maghradze N, Reither K, Beisel C, Tukvadze N, Avaliani Z, Gagneux S. Publisher Correction: Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis. Nat Med. 2021;27(7):1308. DOI: 10.1038/s41591-021-01417-3
Haraka F, Kakolwa M, Schumacher S.G, Nathavitharana R.R, Denkinger C.M, Gagneux S, Reither K, Ross A. Impact of the diagnostic test Xpert MTB/RIF on patient outcomes for tuberculosis (Review). Cochrane Database Syst Rev. 2021;2021(4):CD012972. DOI: 10.1002/14651858.CD012972.pub2
Hiza H, Hella J, Arbués A, Magani B, Sasamalo M, Gagneux S, Reither K, Portevin D. Case-control diagnostic accuracy study of a non-sputum CD38-based TAM-TB test from a single milliliter of blood. Sci Rep. 2021;11(1):13190. DOI: 10.1101/2021.03.10.21253246
Hodel N.C, Hamad A, Reither K, Kasella I.M, Abdulla S, Schoetzau A, Hatz C.F.R, Mayr M. Comparison of two different semiquantitative urinary dipstick tests with albumin-to-creatinine ratio for screening and classification of albuminuria according to KDIGO. A diagnostic test study. Diagnostics. 2021;11(1):81. DOI: 10.3390/diagnostics11010081
Minja L.T, Hella J, Mbwambo J, Nyandindi C, Omary U.S, Levira F, Mpagama S, Shimwela M, Okuma J, Gagneux S, Bruce R.D, Reither K. High burden of tuberculosis infection and disease among people receiving medication-assisted treatment for substance use disorder in Tanzania. PLoS One. 2021;16(4):e0250038. DOI: 10.1371/journal.pone.0250038
Ticlla M.R, Hella J, Hiza H, Sasamalo M, Mhimbira F, Rutaihwa L.K, Droz S, Schaller S, Reither K, Hilty M, Comas I, Beisel C, Schmid C.D, Fenner L, Gagneux S. The sputum microbiome in pulmonary tuberculosis and its association with disease manifestations: a cross-sectional study. Front Microbiol. 2021;12:633396. DOI: 10.3389/fmicb.2021.633396
Arpagaus A, Franzeck F.C, Sikalengo G, Ndege R, Mnzava D, Rohacek M, Hella J, Reither K, Battegay M, Glass T.R, Paris D.H, Bani F, Rajab O.N, Weisser M, Kiularco Study Group. Extrapulmonary tuberculosis in HIV-infected patients in rural Tanzania: the prospective Kilombero and Ulanga antiretroviral cohort. PLoS One. 2020;15(3):e0229875. DOI: 10.1371/journal.pone.0229875
Haraka F, Schumacher S.G, Ross A, Mantsoki A, Gagneux S, Reither K, Denkinger C.M. Effect of history of tuberculosis on specificity of Xpert MTB/RIF. Eur Respir J. 2020;56(3):2000343. DOI: 10.1183/13993003.00343-2020
Hodel N.C, Hamad A, Reither K, Mwangoka G, Kasella I, Praehauser C, Abdulla S, Hatz C.F.R, Mayr M. Assessment of diabetes and prediabetes prevalence and predictors by HbA1c in a population from sub-Saharan Africa with a high proportion of anemia: a prospective cross-sectional study. BMJ Open Diabetes Res Care. 2020;8(1):e000939. DOI: 10.1136/bmjdrc-2019-000939
Ndege R, Ngome O, Bani F, Temba Y, Wilson H, Vanobberghen F, Hella J, Gingo W, Sasamalo M, Mnzava D, Kimera N, Hiza H, Wigayi J, Mapesi H, Kato I.B, Mhimbira F, Reither K, Battegay M, Paris D.H, Weisser M, Rohacek M. Ultrasound in managing extrapulmonary tuberculosis: a randomized controlled two-center study. BMC Infect Dis. 2020;20:349. DOI: 10.1186/s12879-020-05073-9
Abidi S.K, Harris M, Muyoyeta M, Dheda K, Esmail A, Reither K, Breuninger M, Qi A, Denkinger C, Korobitsyn A, Pai M, Benedetti A, Khan F.A. An individual patient data meta-analysis to estimate the diagnostic accuracy of a machine learning-based software for analyzing chest x-rays of persons with symptoms of pulmonary tuberculosis: preliminary findings. Am J Respir Crit Care Med, 2019;199:A5167. DOI: 10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A5167
Conference Paper
Amelio P, Portevin D, Hella J, Reither K, Kamwela L, Lweno O, Tumbo A, Geoffrey L, Ohmiti K, Ding S, Pantaleo G, Daubenberger C, Perreau M. HIV infection functionally impairs Mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses. J Virol. 2019;93(5):e01728-18. DOI: 10.1128/JVI.01728-18
Maghradze N, Jugheli L, Borrell S, Tukvadze N, Aspindzelashvili R, Avaliani Z, Reither K, Gagneux S. Classifying recurrent Mycobacterium tuberculosis cases in Georgia using MIRU-VNTR typing. PLoS One. 2019;14(10):e0223610. DOI: 10.1371/journal.pone.0223610
Mhalu G, Hella J, Mhimbira F, Said K, Mosabi T, Mlacha Y.P, Schindler C, Gagneux S, Reither K, de Hoogh K, Weiss M.G, Zemp E, Fenner L. Pathways and associated costs of care in patients with confirmed and presumptive tuberculosis in Tanzania: a cross-sectional study. BMJ Open. 2019;9(4):e025079. DOI: 10.1136/bmjopen-2018-025079
Mhalu G, Weiss M.G, Hella J, Mhimbira F, Mahongo E, Schindler C, Reither K, Fenner L, Zemp E, Merten S. Explaining patient delay in healthcare seeking and loss to diagnostic follow-up among patients with presumptive tuberculosis in Tanzania: a mixed-methods study. BMC Health Serv Res. 2019;19:217. DOI: 10.1186/s12913-019-4030-4
Mhimbira F, Hiza H, Mbuba E, Hella J, Kamwela L, Sasamalo M, Ticlla M, Said K, Mhalu G, Chiryamkubi M, Schindler C, Reither K, Gagneux S, Fenner L. Prevalence and clinical significance of respiratory viruses and bacteria detected in tuberculosis patients compared to household contact controls in Tanzania: a cohort study. Clin Microbiol Infect. 2019;25(1):107 e1-107 e7. DOI: 10.1016/j.cmi.2018.03.019
Nathavitharana R.R, Yoon C, Macpherson P, Dowdy D.W, Cattamanchi A, Somoskovi A, Broger T, Ottenhoff T.H.M, Arinaminpathy N, Lonnroth K, Reither K, Cobelens F, Gilpin C, Denkinger C.M, Schumacher S.G. Guidance for studies evaluating the accuracy of tuberculosis triage tests. J Infect Dis. 2019;220(Suppl. 3):S116-S125. DOI: 10.1093/infdis/jiz243
Ndege R, Weisser M, Elzi L, Diggelmann F, Bani F, Gingo W, Sikalengo G, Mapesi H, McHomvu E, Kamwela L, Mnzava D, Battegay M, Reither K, Paris D.H, Rohacek M. Sonography to rule out tuberculosis in sub-Saharan Africa: a prospective observational study. Open Forum Infect Dis. 2019;6(4):ofz154. DOI: 10.1093/ofid/ofz154
Nooh F, Crump L, Hashi A, Tschopp R, Schelling E, Reither K, Hattendorf J, Ali S.M, Obrist B, Utzinger J, Zinsstag J. The impact of pastoralist mobility on tuberculosis control in Ethiopia: a systematic review and meta-synthesis. Infect Dis Poverty. 2019;8:73. DOI: 10.1186/s40249-019-0583-z
Rutaihwa L, Menardo F, Stucki D, Gygli S.M, Ley S.D, Malla B, Feldmann J, Borrell S, Beisel C, Middelkoop K, Carter J.E, Diero L, Ballif M, Jugheli L, Reither K, Fenner L, Brites D, Gagneux S. Multiple introductions of Mycobacterium tuberculosis lineage 2-Beijing into Africa over centuries. Front Ecol Evol. 2019;7:112. DOI: 10.3389/fevo.2019.00112
Journal Article
Rutaihwa L.K, Sasamalo M, Jaleco A, Hella J, Kingazi A, Kamwela L, Kingalu A, Malewo B, Shirima R, Dötsch A, Feldmann J, Reinhard M, Borrell S, Brites D, Reither K, Doulla B, Fenner L, Gagneux S. Insights into the genetic diversity of Mycobacterium tuberculosis in Tanzania. PLoS One. 2019;14(4):e0206334. DOI: 10.1371/journal.pone.0206334
Santos V.S, Goletti D, Kontogianni K, Adams E.R, Molina-Moya B, Dominguez J, Crudu V, Martins-Filho P.R.S, Ruhwald M, Lawson L, Bimba J.S, Garcia-Bastero A.L, Petrone L, Kabeer B.S, Reither K, Cuevas L.E. Acute phase proteins and IP-10 as triage tests for the diagnosis of tuberculosis: a systematic review and meta-analysis. Clin Microbiol Infect. 2019;25(2):169-177. DOI: 10.1016/j.cmi.2018.07.017
Tweed C.D, Dawnson R, Burger D.A, Conradie A, Crook A.M, Mendel C.M, Conradie F, Diacon A.H, Ntinginya E.N, Everitt D.E, Haraka F, Li M, van Niekerk C.H, Okwera A, Rassool M.S, Reither K, Sebe M.A, Staples S, Variava E, Spigelman M. Bedaquiline, moxifloxacin, pretomanid, and pyrazinamide during the first 8 weeks of treatment of patients with drug-susceptible or drug-resistant pulmonary tuberculosis: a multicentre, open-label, partially randomised, phase 2b trial. Lancet Respir Med. 2019;7:1048-1058. DOI: 10.1016/S2213-2600(19)30366-2
Boillat-Blanco N, Tumbo A.N, Perreau M, Amelio P, Ramaiya K.L, Mganga M, Schindler C, Gagneux S, Reither K, Probst-Hensch N, Pantaleo G, Daubenberger C, Portevin D. Hyperglycaemia is inversely correlated with live M. bovis BCG-specific CD4+ T cell responses in Tanzanian adults with latent or active tuberculosis. Immun Inflamm Dis. 2018;6(2):345-353. DOI: 10.1002/iid3.222
Haraka F, Nathavitharana R.R, Schumacher S.G, Kakolwa M, Denkinger C.M, Gagneux S, Reither K, Ross A. Impact of diagnostic test Xpert MTB/RIF® on health outcomes for tuberculosis. Cochrane Database Syst Rev. 2018(2):CD012972. DOI: 10.1002/14651858.CD012972
Journal Item
Hella J, Cercamondi C.I, Mhimbira F, Sasamalo M, Stoffel N, Zwahlen M, Bodmer T, Gagneux S, Reither K, Zimmermann M.B, Risch L, Fenner L. Anemia in tuberculosis cases and household controls from Tanzania: contribution of disease, coinfections, and the role of hepcidin. PLoS One. 2018;13(4):e0195985. DOI: 10.1371/journal.pone.0195985
Hodel N.C, Hamad A, Praehauser C, Mwangoka G, Kasella I.M, Reither K, Abdulla S, Hatz C.F.R, Mayr M. The epidemiology of chronic kidney disease and the association with non-communicable and communicable disorders in a population of sub-Saharan Africa. PLoS One. 2018;13(10):e0205326. DOI: 10.1371/journal.pone.0205326
Sabi I, Rachow A, Mapamba D, Clowes P, Ntinginya N.E, Sasamalo M, Kamwela L, Haraka F, Hoelscher M, Paris D.H, Saathoff E, Reither K. Xpert MTB/RIF Ultra assay for the diagnosis of pulmonary tuberculosis in children: a multicentre comparative accuracy study. J Infect. 2018;77(4):321-327. DOI: 10.1016/j.jinf.2018.07.002
Sikalengo G, Hella J, Mhimbira F, Rutaihwa L.K, Bani F, Ndege R, Sasamalo M, Kamwela L, Said K, Mhalu G, Mlacha Y, Hatz C, Knopp S, Gagneux S, Reither K, Utzinger J, Tanner M, Letang E, Weisser M, Fenner L. Distinct clinical characteristics and helminth co-infections in adult tuberculosis patients from urban compared to rural Tanzania. Infect Dis Poverty. 2018;7:24. DOI: 10.1186/s40249-018-0404-9
Zoller T, Mfinanga E.H, Zumba T.B, Asilia P.J, Mutabazi E.M, Wimmersberger D, Kurth F, Mhimbira F, Haraka F, Reither K. Chronic airflow obstruction in Tanzania - a cross-sectional study. BMC Pulm Med. 2018;18:11. DOI: 10.1186/s12890-018-0577-9
Aarnoutse R.E, Kibiki G.S, Reither K, Semvua H.H, Haraka F, Mtabho C.M, Mpagama S.G, van den Boogaard J, Sumari-de Boer I.M, Magis-Escurra C, Wattenberg M, Logger J.G.M, Te Brake L.H.M, Hoelscher M, Gillespie S.H, Colbers A, Phillips P.P.J, Plemper van Balen G, Boeree M.J, Pan Acea Consortium. Pharmacokinetics, tolerability, and bacteriological response of rifampin administered at 600, 900, and 1,200 milligrams daily in patients with pulmonary tuberculosis. Antimicrob Agents Chemother. 2017;61(11):e01054-17. DOI: 10.1128/AAC.01054-17
Amelio P, Portevin D, Reither K, Mhimbira F, Mpina M, Tumbo A, Nickel B, Marti H, Knopp S, Ding S, Penn-Nicholson A, Darboe F, Ohmiti K, Scriba T.J, Pantaleo G, Daubenberger C, Perreau M. Mixed Th1 and Th2 Mycobacterium tuberculosis-specific CD4 T cell responses in patients with active pulmonary tuberculosis from Tanzania. PLoS Negl Trop Dis. 2017;11(7):e0005817. DOI: 10.1371/journal.pntd.0005817
Boeree M.J, Heinrich N, Aarnoutse R, Diacon A.H, Dawson R, Rehal S, Kibiki G.S, Churchyard G, Sanne I, Ntinginya N.E, Minja L.T, Hunt R.D, Charalambous S, Hanekom M, Semvua H, Mpagama S.G, Manyama C, Mtafya B, Reither K, Wallis R.S, Venter A, Narunsky K, Mekota A, Henne S, Colbers A, van Balen G.P, Gillespie S.H, Phillips P.P.J, Hoelscher M. High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial. Lancet Infect Dis. 2017;17(1):39-49. DOI: 10.1016/S1473-3099(16)30274-2
Journal Article
Hiza H, Doulla B, Sasamalo M, Hella J, Kamwela L, Mhimbira F, Reither K, Gagneux S, Jugheli L, Fenner L. Preservation of sputum samples with cetylpyridinium chloride (CPC) for tuberculosis cultures and Xpert MTB/RIF in a low-income country. BMC Infect Dis. 2017;17:542. DOI: 10.1186/s12879-017-2642-z
Mhimbira F, Hella J, Said K, Kamwela L, Sasamalo M, Maroa T, Chiryamkubi M, Mhalu G, Schindler C, Reither K, Knopp S, Utzinger J, Gagneux S, Fenner L. Prevalence and clinical relevance of helminth co-infections among tuberculosis patients in urban Tanzania. PLoS Negl Trop Dis. 2017;11(2):e0005342. DOI: 10.1371/journal.pntd.0005342
Reither K. Improving the diagnostics of tuberculosis - clinical evaluation of four new diagnostics. Basel: Univ. Basel, 2017. Doctoral Thesis, University of Basel, Faculty of Science DOI: 10.5451/unibas-006709641
Thesis
Said K, Verver S, Kalingonji A, Lwilla F, Mkopi A, Charalambous S, Reither K. Tuberculosis among HIV-infected population: incidence and risk factors in rural Tanzania. Afr Health Sci. 2017;17(1):208-215. DOI: 0.4314/ahs.v17i1.26
Bholla M, Kapalatad N, Masikad E, Chandee H, Jughelia L, Sasamaloc M, Glass T.R, Beck H.P, Reither K. Evaluation of Xpert® MTB/RIF and Ustar EasyNATTM TB IAD for diagnosis of TB lymphadenitis of children in Tanzania. BMC Infect Dis. 2016;16:246. DOI: 10.1186/s12879-016-1578-z
Boillat-Blanco N, Bovet P, Ramaiya K.L, Mganga M, Minja L.T, Saleh L, Imboden M, Schindler C, Gagneux S, Daubenberger C, Reither K, Probst-Hensch N. Association between tuberculosis, diabetes and 25 hydroxyvitamin D in Tanzania: a longitudinal case control study. BMC Infect Dis. 2016;16:626. DOI: 10.1186/s12879-016-1960-x
Boillat-Blanco N, Ramaiya K.L, Mganga M, Minja L.T, Bovet P, Schindler C, Von Eckardstein A, Gagneux S, Daubenberger C, Reither K, Probst-Hensch N. Transient hyperglycemia in patients with tuberculosis in Tanzania: implications for diabetes screening algorithms. J Infect Dis. 2016;213(7):1163-1172. DOI: 10.1093/infdis/jiv568
Mhimbira F, Hella J, Maroa T, Kisandu S, Chiryamkubi M, Said K, Mhalu G, Mkopi A, Mutayoba B, Reither K, Gagneux S, Fenner L. Home-based and facility-based directly observed therapy of tuberculosis treatment under programmatic conditions in urban Tanzania. PLoS One. 2016;11(8):e0161171. DOI: 10.1371/journal.pone.0161171
Petrone L, Cannas A, Vanini V, Cuzzi G, Aloi F, Nsubuga M, Sserunkuma J, Nazziwa R.A, Jugheli L, Lukindo T, Girardi E, Antinori A, Pucci L, Reither K, Goletti D. Blood and urine inducible protein 10 as potential markers of disease activity. Int J Tuberc Lung Dis. 2016;20(11):1554-1561. DOI: 10.5588/ijtld.16.0342
Reither K. Aufbau von Kapizitäten für klinische Tuberkulosesstudien: das Schweiz-Tansania Modell. In: Reither K, ed. Deutsches Zentralkomitee zur Bekämpfung der Tuberkulose: 39. Informationsbericht, 26-31. Berlin: DZK, 2016
Book Section
Sikalengo G, Ramirez A, Faini D, Mwamelo K, Battegay M, Jugheli L, Hatz C, Reither K, Letang E. Tuberculous spondylitis diagnosed through Xpert MTB/RIF assay in urine: a case report. BMC Infect Dis. 2016;16:514. DOI: 10.1186/s12879-016-1844-0
Zumla A, Rao M, Wallis R.S, Kaufmann S.H, Rustomjee R, Mwaba P, Vilaplana C, Yeboah-Manu D, Chakaya J, Ippolito G, Azhar E, Hoelscher M, Maeurer M, Host-Directed Therapies Network consortium. Host-directed therapies for infectious diseases: current status, recent progress, and future prospects. Lancet Infect Dis. 2016;16(4):e47-63. DOI: 10.1016/S1473-3099(16)00078-5
Boillat-Blanco N, Mganga M, Ramaiya K.L, Mrangu N.S, Minja L.T, Schindler C, Von Eckardstein A, Gagneux S, Daubenberger C, Reither K, Probst-Hensch N. Longitudinal evolution of diabetes during tuberculosis in Dar es Salaam, Tanzania. Trop Med Int Health, 2015;20(Suppl. 1):57-58. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland
Conference Paper
Cabibbe A.M, Miotto P, Moure R, Alcaide F, Feuerriegel S, Pozzi G, Nikolayevskyy V, Drobniewski F, Niemann S, Reither K, Cirillo D.M. Lab-on-chip based platform for fast molecular diagnosis of multi-drug resistant tuberculosis. J Clin Microbiol. 2015;53(12):3876-3880. DOI: 10.1128/JCM.01824-15
Dawson R, Diacon A.H, Everitt D, Van Niekerk C, Donald P.R, Burger D.A, Schall R, Spigelman M, Conradie A, Eisenach K, Venter A, Ive P, Page-Shipp L, Variava K, Reither K, Ntinginya E.N, Pym A, Von Groote-Bindlingmaier F, Mendel C.M. Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resistant pul. Lancet. 2015;385(9979):1738-1747. DOI: 10.1016/S0140-6736(14)62002-X
Heinrich N, Dawson R, du Bois J, Narunsky K, Horwith G, Phipps A.J, Nacy C.A, Aarnoutse R.E, Boeree M.J, Gillespie S.H, Venter A, Henne S, Rachow A, Phillips P.P, Hoelscher M, Diacon A.H, Pan African Consortium for the Evaluation of Antituberculosis Antibiotics (PanACEA). Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients. J Antimicrob Chemother. 2015;70(5):1558-1566. DOI: 10.1093/jac/dku553
Kroidl I, Clowes P, Reither K, Mtafya B, Rojas-Ponce G, Ntinginya E.N, Kalomo M, Minja L.T, Kowuor D, Saathoff E, Kroidl A, Heinrich N, Maboko L, Bates M, O'Grady J, Zumla A, Hoelscher M, Rachow A. Performance of urine lipoarabinomannan assays for paediatric tuberculosis in Tanzania. Eur Respir J. 2015;46(3):761-770. DOI: 10.1183/09031936.00003315
Kroidl I, Podola L, Clowes P, Rachow A, Reither K, Saathoff E, Geldmacher C, Kalomo M, Ntinginya E.N, Maboko L, Kroidl A, Loescher T, Hoelscher M. Diagnostic value of three interferon-gamma release assays for paediatric tuberculosis in a high HIV/TB -prevalence setting in south-west Tanzania. Trop Med Int Health, 2015;20(Suppl. 1):151. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland
Conference Paper
Lenz N, Schindler T, Kagina B.M, Zhang J.D, Lukindo T, Mpina M, Bang P, Kromann I, Hoff S.T, Andersen P, Reither K, Churchyard G.J, Certa U, Daubenberger C.A. Antiviral innate immune activation in HIV infected adults negatively affects H1/IC31(R) induced vaccine-specific memory CD4+ T cells. Clin Vaccine Immunol. 2015;22(7):688-696. DOI: 10.1128/CVI.00092-15
Mbuba E, Makene V, Masanja H, Sasamalo M, Mwangoka G, Munuo L, Mhimbira F.A, Reither K, Dartois V, Mugittu K. Genetic diversity of Mycobacterium tuberculosis and mutation profiles in drug resistance associated genes in Bagamoyo District, Tanzania. Trop Med Int Health, 2015;20(Suppl. 1):198. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland
Conference Paper
Melendez J, van Ginneken B, Maduskar P, Philipsen R.H, Reither K, Breuninger M, Adetifa I.M, Maane R, Ayles H, Sanchez C.I. A novel multiple-instance learning-based approach to computer-aided detection of tuberculosis on chest x-rays. IEEE Trans Med Imaging. 2015;34(1):179-192. DOI: 10.1109/TMI.2014.2350539
Mhimbira F.A, Bholla M, Sasamalo M, Mukurasi W, Hella J, Jugheli L, Reither K. Detection of Mycobacterium tuberculosis by EasyNAT (TM) diagnostic kit in sputum samples from Tanzania. Trop Med Int Health, 2015;20(Suppl. 1):190. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland
Conference Paper
Mhimbira F.A, Bholla M, Sasamalo M, Mukurasi W, Hella J.J, Jugheli L, Reither K. Detection of Mycobacterium tuberculosis by EasyNAT diagnostic kit in sputum samples from Tanzania. J Clin Microbiol. 2015;53(4):1342-1344. DOI: 10.1128/JCM.03037-14
Nicol M.P, Gnanashanmugam D, Browning R, Click E.S, Cuevas L.E, Detjen A, Graham S.M, Levin M, Makhene M, Nahid P, Perez-Velez C.M, Reither K, Song R, Spiegel H.M, Worrell C, Zar H.J, Walzl G. A blueprint to address research gaps in the development of biomarkers for pediatric tuberculosis. Clin Infect Dis. 2015;61(Suppl. 3):S164-S172. DOI: 10.1093/cid/civ613
Olaru I.D, Rachow A, Lange C, Ntinginya N.E, Reither K, Hoelscher M, Vollrath O, Niemann S. Ascertaining in vivo virulence of Mycobacterium tuberculosis lineages in patients in Mbeya, Tanzania. Int J Tuberc Lung Dis. 2015;19(1):70-73. DOI: 10.5588/ijtld.14.0403
Petrone L, Cannas A, Aloi F, Nsubuga M, Sserumkuma J, Nazziwa R.A, Jugheli L, Lukindo T, Girardi E, Reither K, Goletti D. Blood or urine IP-10 cannot discriminate between active tuberculosis and respiratory diseases different from tuberculosis in children. Biomed Res Int. 2015;2015:ID 589471. DOI: 10.1155/2015/589471
Portevin D, Moukambi F, Mpina M, Bauer A, Haraka F, Chachage M, Metzger P, Saathoff E, Clowes P, Ntinginya N.E, Rachow A, Hoelscher M, Reither K, Daubenberger C.A, Geldmacher C. Maturation and mip-1beta production of cytomegalovirus-specific T cell responses in Tanzanian children, adolescents and adults: impact by HIV and Mycobacterium tuberculosis co-infections. PLoS One. 2015;10(5):e0126716. DOI: 10.1371/journal.pone.0126716
Reither K, Jugheli L, Glass T.R, Sasamalo M, Mhimbira F.A, Weetjens B.J, Cox C, Edwards T.L, Mulder C, Beyene N.W, Mahoney A. Evaluation of giant African pouched rats for detection of pulmonary tuberculosis in patients from a high-endemic setting. PLoS One. 2015;10(10):e0135877. DOI: 10.1371/journal.pone.0135877
Reither K, Manyama C, Clowes P, Rachow A, Mapamba D, Steiner A, Ross A, Mfinanga E, Sasamalo M, Nsubuga M, Aloi F, Cirillo D, Jugheli L, Lwilla F. Xpert MTB/RIF assay for diagnosis of pulmonary tuberculosis in children: a prospective, multi-centre evaluation. J Infect. 2015;70(4):392-399. DOI: 10.1016/j.jinf.2014.10.003
Sikalengo G, Ramirez A, Battegay M, Furrer H, Tanner M, Hatz C, Reither K, Letang E. Diagnosis of tuberculous spondylitis through Xpert MTB/RIF assay in urine in rural Africa. Trop Med Int Health, 2015;20(Suppl. 1):192. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland
Conference Paper
Steiner A, Mangu C, van den Hombergh J, Van Deutekom H, van Ginneken B, Clowes P, Mhimbira F, Mfinanga S, Rachow A, Reither K, Hoelscher M. Screening for pulmonary tuberculosis in Tanzanian prison and computer-aided interpretation of chest X-rays. Public Health Action. 2015;5(4):249-254. DOI: 10.5588/pha.15.0037
Zumla A, Chakaya J, Hoelscher M, Ntoumi F, Rustomjee R, Vilaplana C, Yeboah-Manu D, Rasolof V, Munderi P, Singh N, Aklillu E, Padayatchi N, Macete E, Kapata N, Mulenga M, Kibiki G, Mfinanga S, Nyirenda T, Maboko L, Garcia-Basteiro A, Rakotosamimanana N, Bates M, Mwaba P, Reither K, Gagneux S, Edwards S, Mfinanga E, Abdulla S, Cardona P.J, Russell J.B, Gant V, Noursadeghi M, Elkington P, Bonnet M, Menendez C, Dieye T.N, Diarra B, Maiga A, Aseffa A, Parida S, Wejse C, Petersen E, Kaleebu P, Oliver M, Craig G, Corrah T, Tientcheu L, Antonio M, Rao M, McHugh T.D, Sheikh A, Ippolito G, Ramjee G, Kaufmann S.H, Churchyard G, Steyn A, Grobusch M, Sanne I, Martinson N, Madansein R, Wilkinson R.J, Mayosi B, Schito M, Wallis R.S, Maeurer M. Towards host-directed therapies for tuberculosis [Comment]. Nat Rev Drug Discov. 2015;14(8):511-512. DOI: 10.1038/nrd4696
Zumla A, Maeurer M, Host-Directed Therapies Network HDT-NET Consortium. Host-directed therapies for tackling multi-drug resistant TB - learning from the Pasteur-Bechamp debates. Clin Infect Dis. 2015;61(9):1432-1438. DOI: 10.1093/cid/civ631
Breuninger M, van Ginneken B, Philipsen R.H, Mhimbira F, Hella J.J, Lwilla F, van den Hombergh J, Ross A, Jugheli L, Wagner D, Reither K. Diagnostic accuracy of computer-aided detection of pulmonary tuberculosis in chest radiographs: a validation study from sub-Saharan Africa. PLoS One. 2014;9(9):e106381. DOI: 10.1371/journal.pone.0106381
Kroidl I, Clowes P, Mwakyelu J, Maboko L, Kiangi A, Rachow A, Reither K, Jung J, Nsojo A, Saathoff E, Hoelscher M. Reasons for false-positive lipoarabinomannan ELISA results in a Tanzanian population [Short communication]. Scand J Infect Dis. 2014;46(2):144-148. DOI: 10.3109/00365548.2013.853133
Portevin D, Moukambi F, Clowes P, Bauer A, Chachage M, Ntinginya E.N, Mfinanga E, Said K, Haraka F, Rachow A, Saathoff E, Mpina M, Jugheli L, Lwilla F, Marais B.J, Hoelscher M, Daubenberger C, Reither K, Geldmacher C. Assessment of the novel T-cell activation marker-tuberculosis assay for diagnosis of active tuberculosis in children: a prospective proof-of-concept study. Lancet Infect Dis. 2014;14(10):931-938. DOI: 10.1016/S1473-3099(14)70884-9
Reither K, Katsoulis L, Beattie T, Gardiner N, Lenz N, Said K, Mfinanga E, Pohl C, Fielding K.L, Jeffery H, Kagina B.M, Hughes E.J, Scriba T.J, Hanekom W.A, Hoff S.T, Bang P, Kromann I, Daubenberger C, Andersen P, Churchyard G.J. Safety and immunogenicity of H1/IC31(R), an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial. PLoS One. 2014;9(12):e114602. DOI: 10.1371/journal.pone.0114602
Trauner A, Borrell S, Reither K, Gagneux S. Evolution of drug resistance in tuberculosis: recent progress and implications for diagnosis and therapy. Drugs. 2014;74(10):1063-1072. DOI: 10.1007/s40265-014-0248-y
Hella J.J, Hiza H.C, Mfinanga E, Reither K. Paraspinal abscess secondary to tuberculous spondylitis diagnosed by Xpert MTB/RIF assay in rural Tanzania. BMJ Case Rep. 2013;10 Apr 2013:bcr2013009156. DOI: 10.1136/bcr-2013-009156
Miotto P, Mwangoka G, Valente I.C, Norbis L, Sotgiu G, Bosu R, Ambrosi A, Codecasa L.R, Goletti D, Matteelli A, Ntinginya E.N, Aloi F, Heinrich N, Reither K, Cirillo D.M. miRNA signatures in Sera of patients with active pulmonary tuberculosis. PLoS One. 2013;8(11):e80149. DOI: 10.1371/journal.pone.0080149
Mwangoka G.W, Miotto P, Valente I.C, Norbis L, Sotgiu G, Reither K, Heinrich N, Aloi F, Cirillo D.M. Micrornas as biomarker for active tuberculosis infection in immunocompetent and immunodeficient. Am J Trop Med Hyg, 2013;89(5 Suppl.):417
Conference Paper
Pohl C, Jugheli L, Haraka F, Mfinanga E, Said K, Reither K. Pulmonary aspergilloma: a treatment challenge in sub-Saharan Africa. PLoS Negl Trop Dis. 2013;7(10):e2352. DOI: 10.1371/journal.pntd.0002352
Said K, Mkopi A, Verver S, Lwilla F, Churchyard G, Shekalaghe S, Battegay M, Reither K. Improved services to enrollees into an HIV rural care and treatment center in Tanzania [Short communication]. Pan Afr Med J. 2013;16:34. DOI: 10.11604/pamj.2013.16.34.1642
Beyene N, Mahoney A, Cox C, Weetjens B, Makingi G, Mgode G, Durgin A, Kuipers D, Jubitana M, Egwaga S, Kamara D, Lwilla F, Mfinanga S.G, Kahwa A, Machang'u R, Kazwala R, Reither K, Kaufmann S.H.E, Poling A. APOPO's tuberculosis research agenda: achievements, challenges and prospects. Tanzan J Health Res. 2012;14(2):1-13. DOI: 10.4314/thrb.v14i2.5
Journal Article
Haraka F, Rutaihwa L.K, Battegay M, Reither K. Mycobacterium intracellulare infection in non-HIV infected patient in a region with a high burden of tuberculosis. BMJ Case Rep. 2012;8 May 2012:bcr0120125713. DOI: 10.1136/bcr.01.2012.5713
Mahoney A, Weetjens B.J, Cox C, Beyene N, Reither K, Makingi G, Jubitana M, Kazwala R, Mfinanga S.G, Kahwa A, Durgin A, Poling A. Pouched rats' detection of tuberculosis in human sputum: comparison to culturing and polymerase chain reaction. Tuberc Res Treat. 2012;2012:716989. DOI: 10.1155/2012/716989
Ntinginya E.N, Squire S.B, Millington K.A, Mtafya B, Saathoff E, Heinrich N, Rojas-Ponce G, Kowuor D, Maboko L, Reither K, Clowes P, Hoelscher M, Rachow A. Performance of the Xpert((R)) MTB/RIF assay in an active case-finding strategy: a pilot study from Tanzania [Short communication]. Int J Tuberc Lung Dis. 2012;16(11):1468-1470. DOI: 10.5588/ijtld.12.0127
Rachow A, Clowes P, Saathoff E, Mtafya B, Michael E, Ntinginya E.N, Kowour D, Rojas-Ponce G, Kroidl A, Maboko L, Heinrich N, Reither K, Hoelscher M. Increased and expedited case detection by Xpert MTB/RIF assay in childhood tuberculosis: a prospective cohort study. Clin Infect Dis. 2012;54(10):1388-1396. DOI: 10.1093/cid/cis190
Rachow A, Zumla A, Heinrich N, Rojas-Ponce G, Mtafya B, Reither K, Ntinginya E.N, O'Grady J, Huggett J, Dheda K, Boehme C, Perkins M, Saathoff E, Hoelscher M. Rapid and accurate detection of Mycobacterium tuberculosis in sputum samples by Cepheid Xpert MTB/RIF assay - a clinical validation study. PLoS One. 2011;6(6):e20458. DOI: 10.1371/journal.pone.0020458
Buchholz U, Kobbe R, Danquah I, Zanger P, Reither K, Abruquah H.H, Grobusch M.P, Ziniel P, May J, Mockenhaupt F.P. Multiplicity of Plasmodium falciparum infection following intermittent preventive treatment in infants. Malar J. 2010;9:244. DOI: 10.1186/1475-2875-9-244