Is <em>Caenorhabditis elegans</em> the magic bullet for anthelminthic drug discovery? (Publications)
Recent advances in handling and readout have facilitated high-throughput screens with Caenorhabditis elegans. A new study demonstrates that C. elegans is a useful tool in high-throughput anthelminthic
Synthesis and antiprotozoal activities of new 3-azabicyclo[3.2.2]nonanes (Publications)
Some antimalarial agents in use typically bear basic side chains as ligands. Such ligands were attached to the amino substituent of a bridgehead atom of already antiprotozoal active 3-azabicyclo[3.2.2
Malaria molecular epidemiology: lessons from the International Centers of Excellence for Malaria Research Network (Publications)
Molecular epidemiology leverages genetic information to study the risk factors that affect the frequency and distribution of malaria cases. This article describes molecular epidemiologic investigation
Burden of serious fungal infections in Tanzania (Publications)
The incidence and prevalence of fungal infections in Tanzania remains unknown. We assessed the annual burden in the general population and among populations at risk. Data were extracted from 2012 repo
A novel isothermal microcalorimetry tool to assess drug effects on<em> Ancylostoma ceylanicum</em> and <em>Necator americanus</em> (Publications)
Soil-transmitted helminths, which affect the poorest communities, worldwide cause a range of symptoms and morbidity, yet few treatment options are available and drug resistance is a concern. To improv
A novel pyrazolopyridine with<em> in vivo</em> activity in <em>Plasmodium berghei</em>- and <em>Plasmodium falciparum</em>-infected mouse models from... (Publications)
Toward improving pharmacokinetics, in vivo efficacy, and selectivity over hERG, structure-activity relationship studies around the central core of antimalarial imidazopyridazines were conducted. This
A blueprint to address research gaps in the development of biomarkers for pediatric tuberculosis (Publications)
Childhood tuberculosis contributes significantly to the global tuberculosis disease burden but remains challenging to diagnose due to inadequate methods of pathogen detection in paucibacillary pediatr
Benzo[b]quinolizinium derivatives have a strong antimalarial activity and inhibit indoleamine dioxygenase (Publications)
The heme-containing enzymes indoleamine 2,3-dioxygenase-1 and -2 (IDO-1, -2) catalyze the conversion of the essential amino acid tryptophan into kynurenine. Metabolites of the kynurenine pathway and I
Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood (Publications)
BACKGROUND: European cross-sectional studies have suggested that prenatal and postnatal farm exposure decreases the risk of allergic diseases in childhood. Underlying immunologic mechanisms are still