Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives (Publications)
4,4''-Diamidino-m-terphenyl (1) and 36 analogues were prepared and assayed in vitro against T rypanosoma brucei rhodesiense , Trypanosoma cruzi , Plasmodium falciparum , and Leishmania amazonensis . T
Antigenicity and immunogenicity of a novel chimeric peptide antigen based on the <em>P. vivax</em> circumsporozoite protein (Publications)
BACKGROUND: Plasmodium vivax circumsporozoite (PvCS) protein is a major sporozoite surface antigen involved in parasite invasion of hepatocytes and is currently being considered as vaccine candidate.
Structure-activity relationship studies of pyrrolone antimalarial agents (Publications)
Previously reported pyrrolones, such as TDR32570, exhibited potential as antimalarial agents; however, while these compounds have potent antimalarial activity, they suffer from poor aqueous solubility
Health of mobile pastoralists in the Sahel - assessment of 15 years of research and development (Publications)
In the Sahel, between Mauritania and Somalia including Northern Kenya, about 20-30 million people live as mobile pastoralists. The rhythm of their migration follows the seasons and the availability of
Development and back-extrapolation of NO2 land use regression models for historic exposure assessment in Great Britain (Publications)
Modelling historic air pollution exposures is often restricted by availability of monitored concentration data. We evaluated back-extrapolation of LUR models for annual mean NO2 concentrations in Grea
Sociocultural determinants of anticipated vaccine acceptance for acute watery diarrhea in early childhood in Katanga province, Democratic Republic of... (Publications)
Rotavirus and oral cholera vaccines have the potential to reduce diarrhea-related child mortality in low-income settings and are recommended by the World Health Organization. Uptake of vaccination dep
Household survey of pesticide practice, deliberate self-harm and suicide in the Sundarban region of west Bengal, India (Publications)
The toxicological impact and intentional ingestion of pesticides are major public health concerns globally. This study aimed to estimate the extent of deliberate self-harm (DSH) and suicides (suicidal
Treatment of mucosal leishmaniasis (<em>L. infantum</em>) with Miltefosine in a patient with good syndrome (Publications)
We report on a 76-year old patient with recurrent mucosal leishmaniasis. Multiple treatment regimens were administered. After the second relapse, immunologic workup and review of the patient's history
Acceptability and feasibility of mifepristone-misoprostol for menstrual regulation in Bangladesh (Publications)
CONTEXT: Annually, more than 700,000 women turn to menstrual regulation, or uterine evacuation with vacuum aspiration; many more resort to unsafe abortion. Using pills for the evacuation of the uterus