Early life adversity, biological adaptation, and human capital: evidence from an interrupted malaria control program in Zambia (Publications)
adaptation - immunity formation - for human capital accumulation. Using variation in early life malaria risk generated by an interrupted disease control program in Zambia, we show that exposure to infectious [...] infectious diseases during the first two years of life can reduce the harmful effects of malaria exposure on cognitive development during the preschool years. These findings suggest a non-linear and traj
Nonrandom selection and multiple blood feeding of human hosts by <em>Anopheles </em>vectors: implications for malaria transmission in Papua New Guinea (Publications)
feeding of human hosts by Anopheles mosquitoes may exacerbate malaria transmission. Both patterns of blood feeding and their relationship to malaria epidemiology were investigated in Anopheles vectors in Papua [...] mosquito was determined by matching the blood-meal genetic profile to the villagers' genetic profiles. Malaria infection in humans was determined by PCR test of blood samples. The results show nonrandom distribution [...] infection was higher in this age group, suggesting males in...
Multisectoral approach to support use of insecticide-treated net for malaria prevention among mobile and migrant populations in Myanmar: a systematic... (Publications)
BACKGROUND: Myanmar is a premalaria elimination country with artemisinin-resistant malaria. A strategy for transmission control is focused on vulnerable groups such as mobile and migrant populations (MMPs) [...] (MSA). METHODS: This narrative systematic review addressed MSAs targeted to MMPs in Myanmar for malaria prevention. We searched relevant studies in electronic databases and present the narrative findings
Study protocol of a cluster randomized controlled trial of strategies to increase antenatal iron and folic acid supplementation and malaria... (Publications)
post-partum anaemia and malaria infection. Anaemia will be assessed using HEMOCUE devices; malaria infections will be assessed using standard rapid diagnostic tests named CareStart Malaria Pf (HRP2) Ag RDT (Multi [...] of antenatal iron and folic acid supplementation (IFAS) and intermittent preventive treatment of malaria in pregnancy (IPTp) remains low in many countries. Evidence on the most effective ways to increase [...] cost, impact and relative cost-effectiveness of two complementary...
Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of <em>Plasmodium falciparum</em> malaria (Publications)
and perpetual increase in malaria incidence necessitates the development of novel anti-malarials. Histone deacetylases (HDAC) has been shown to be a promising target for malaria, despite this, there are [...] are no HDAC inhibitors in clinical trials for malaria treatment. This can be attributed to the poor pharmacokinetics, bioavailability and selectivity of the HDAC inhibitors. METHODS: A collection of HDAC [...] orally and subcutaneously. CONCLUSION: FNDR-20123 may be a suitable candidate for...
A systematic literature review of microscopy methods reported in malaria clinical trials (Publications)
Microscopy of stained blood films is essential for the diagnosis of malaria, differentiation of parasite species, and estimation of parasite density performed for assessments of antimalarial drug efficacy [...] the emergence or spread of antimalarial drug resistance. Although evidence-based guidelines for malaria microscopy methods exist, the age-old microscopy techniques for parasitological assessments are subject