Reductions in malaria and anaemia case and death burden at hospitals following scale-up of malaria control in Zanzibar, 1999-2008 (Publications)
CONCLUSIONS: Scaling-up effective malaria interventions reduced malaria-related burden at health facilities by over 75% within 5 years. In high-malaria settings, intensified malaria control can substantially [...] groups combined, malaria deaths had fallen by an estimated 90% (95% confidence interval 55-98%)(p < 0.025), malaria in-patient cases by 78% (48-90%), and parasitologically-confirmed malaria out-patient cases [...] BACKGROUND: In Zanzibar, the Ministry of Health and partners...
Geostatistical modelling of malaria indicator survey data to assess the effects of interventions on the geographical distribution of malaria... (Publications)
BACKGROUND: Malaria burden in Uganda has declined disproportionately among regions despite overall high intervention coverage across all regions. The Uganda Malaria Indicator Survey (MIS) 2014-15 was the [...] intervention effects on malaria prevalence in Uganda among children less than 5 years, assess intervention effects at regional level, and estimate geographical distribution of malaria prevalence in the country [...] on malaria prevalence at national and regional levels. Spike-and-slab...
Trends in reported malaria cases and the effects of malaria control in the Democratic Republic of the Congo (Publications)
upscaling of malaria control efforts have taken place over the last 15 years in the Democratic Republic of Congo, the country with the second highest malaria case load after Nigeria. Malaria control int [...] Goals. We analysed the effects of these interventions on malaria cases at health facility level, using a retrospective trend analysis of malaria cases between 2005 and 2014. Data were collected from outpatient [...] represents all eco-epidemiological malaria settings across the country....
Malaria-anemia comorbidity prevalence as a measure of malaria-related deaths in sub-Saharan Africa (Publications)
association of malaria parasitaemia, anemia, and malariaanemia comorbidity with all-cause under-five mortality and evaluated the potential of malaria-anemia comorbidity prevalence to quantify malaria-related [...] utilized to determine the relationship between malaria and mortality in endemic countries. Most of these efforts have focused on deaths directly attributed to malaria, while they overlooked causes of mortality [...] Mortality hazard obtained from malaria-anemia comorbidity prevalence...
Malaria standby emergency treatment (SBET) for travelers visiting malaria endemic areas: a systematic review and meta-analysis (Publications)
Malaria prevention methods for travelers to low or moderate malaria risk areas varies and remains controversial. Standby Emergency Treatment (SBET) for malaria is one possible strategy increasingly recommended [...] proportion carrying SBET, the response to fever (use of SBET, health facility attendance, use of malaria rapid diagnostic test [mRDT]), adverse events to SBET, and the proportion using SBET incorrectly [...] current SBET strategy should be considered, such as better selection of...
Spectrum-malaria: a user-friendly projection tool for health impact assessment and strategic planning by malaria control programmes in sub-Saharan... (Publications)
Scale-up of malaria prevention and treatment needs to continue but national strategies and budget allocations are not always evidence-based. This article presents a new modelling tool projecting malaria infection [...] provinces, from the WHO and malaria atlas project. Impacts over 2016-2030 are projected for insecticide-treated nets (ITNs), indoor residual spraying (IRS), seasonal malaria chemoprevention (SMC), and effective [...] DISCUSSION: Spectrum-Malaria's user-friendly interface and...
False-negative malaria rapid diagnostic tests in Rwanda: impact of <em>Plasmodium falciparum</em> isolates lacking <em>hrp2</em> and declining malaria... (Publications)
and the Plasmodium lactate dehydrogenase (pLDH) to microscopy (thick smears) for the diagnosis of malaria. PCR was used to determine whether deletions of the histidine-rich central repeat region of the hrp2 [...] CONCLUSION: This prospective study of RDT performance coincided with a decline in the intensity of malaria transmission in Kibirizi (fall in slide positivity from 46 to 3%). This decline was associated with [...] could reduce the impact of false-negative HRP2-based RDTs for detection of...