Controlled human malaria infection leads to long-lasting changes in innate and innate-like lymphocyte populations (Publications)
clinically silent. To overcome this limitation, we examined blood samples from a controlled human malaria infection (CHMI) study in a Tanzanian cohort, in which volunteers underwent CHMI with a low or high
The complex relationship of exposure to new <em>Plasmodium</em> infections and incidence of clinical malaria in Papua New Guinea (Publications)
The molecular force of blood-stage infection (molFOB) is a quantitative surrogate metric for malaria transmission at population level and for exposure at individual level. Relationships between molFOB
Malaria prevention strategies and recommendations, from chemoprophylaxis to stand-by emergency treatment: a 10-year prospective study in a Swiss... (Publications)
There are several possible malaria prevention strategies for travellers. In Switzerland, chemoprophylaxis (CP) is recommended for persons visiting areas highly endemic for malaria and stand-by emergency treatment [...] fic malaria preventive recommendations provided and medicines prescribed over time were analysed. Results: In total, 64 858 client-trips were recorded. 91% of travellers planned to visit a malaria endemic [...] treatment (SBET) for areas with moderate to low risk. Objective: To...
Tracking development assistance and government health expenditures for 35 malaria-eliminating countries: 1990-2017 (Publications)
financier for malaria, providing 96% of the total external funding for malaria in 2013, with vector control interventions being the highest cost driver in all regions. Government expenditure on malaria, while [...] health to the 35 countries actively pursuing malaria elimination. Where possible, development assistance for health (DAH) was categorized by spend on malaria intervention. A diverse set of data points were [...] were used to estimate government health budgets expenditure on malaria,...
Estimation of malaria parasite reservoir coverage using reactive case detection and active community fever screening from census data with rapid... (Publications)
areas where malaria transmission has been suppressed by vector control interventions many malaria control and elimination programmes are actively seeking new interventions to further reduce malaria prevalence [...] prevalence, incidence and transmission. Malaria infection prevalence and incidence has been shown to cluster geographically, especially at lower transmission levels, and as such a reactive strategy is frequently [...] infections than random searches, but this effect appears to be...
Clinical and laboratory predictors of death in African children with features of severe malaria: a systematic review and meta-analysis (Publications)
criteria for defining severe malaria have evolved over the last 20 years. We aimed to assess the strength of association of death with features currently characterizing severe malaria through a systematic review [...] Web of Knowledge) were searched to identify publications including African children with severe malaria. PRISMA guidelines were followed. Selection was based on design (epidemiological, clinical and treatment [...] treatment studies), setting (Africa), participants (children < 15...
Open source drug discovery with the malaria box compound collection for neglected diseases and beyond (Publications)
would accelerate the finding of new starting points for drug discovery. The Medicines for Malaria Venture Malaria Box is a collection of over 400 compounds representing families of structures identified [...] in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite. The set has now been distributed to almost 200 research groups globally in the last two [...] domain. This paper reports for the first time on 236 screens that have been...