The relative roles of ANC and EPI in the continuous distribution of LLINs: a qualitative study in four countries (Publications)
through EPI because of a) stronger linkages and involvement between malaria and reproductive health programmes, as compared to malaria and EPI, and b) more complete programme monitoring for ANC-based d [...] Background: The continuous distribution of long-lasting insecticidal nets (LLINs) for malaria prevention, through the antenatal care (ANC) and the Expanded Programme on Immunizations (EPI), is recommended [...] sub-national, and facility-level health staff, and were selected to capture a...
Spatial effects on the multiplicity of <em>Plasmodium falciparum</em> infections (Publications)
homogeneous transmission used in mathematical transmission models for malaria. In the present study an individual-based mathematical malaria transmission model that incorporates multiple parasite clones, variable [...] prevalence or multiplicity of infection (MOI). In traditionally highly malaria endemic regions where most of the population harbours malaria parasites, humans are often infected with multiple parasite clones [...] As malaria is being pushed back on many frontiers and global case...
Reduction in the proportion of fevers associated with <em>Plasmodium falciparum</em> parasitaemia in Africa: a systematic review (Publications)
BACKGROUND: Malaria is almost invariably ranked as the leading cause of morbidity and mortality in Africa. There is growing evidence of a decline in malaria transmission, morbidity and mortality over the [...] presenting with a syndrome of 'presumptive malaria', 3) numerators (number of parasitologically confirmed cases) and denominators (total number of presumptive malaria cases) available, 4) good quality microscopy [...] However, there is still doubt whether this decline is reflected in a...
Pyrimethamine-resistant <em>Plasmodium falciparum</em> parasites among Tanzanian children: a facility-based study using the polymerase chain reaction (Publications)
of the 21 children with clinical malaria had pyrimethamine-resistant parasites. Currently, sulfadoxine-pyrimethamine is considered a potential first-line drug for malaria treatment in most African countries [...] used to estimate the proportion of pyrimethamine-resistant parasites in 101 children reporting with malaria at the hospital in Ifakara, a town in southern Tanzania. The method is based on the observation that [...] suggest that although sulfadoxine-pyrimethamine could still be effective...
High sensitivity detection of <em>Plasmodium</em> species reveals positive correlations between infections of different species, shifts in age... (Publications)
Plasmodium vivax and Plasmodium malariae. The development of a high-throughput molecular species diagnostic assay now enables routine PCR-based surveillance of malaria infections in large field and in [...] falciparum, P. vivax, P. malariae and Plasmodium ovale were observed in LDR-FMA compared to LM diagnosis (p < 0.001). Increases were particularly pronounced for P. malariae (3.9% vs 13.4%) and P. ovale [...] molecular diagnosis reveals patterns of malaria risk that are significantly...
Aktueller Malariaschutz bei Kurzzeitaufenthalt (Publications)
average of 800 malaria cases are recorded annually in Germany. One person in a hundred dies of the disease. Travel advice given by experienced physicians is essential to raise awareness of malaria risk in endemic [...] endemic areas. Rational mosquito protection on skin and textiles reduces the risk of malaria and other arthropod-transmitted diseases (e. g. dengue fever). Regular intake of an antimalarial drugs to suppress [...] doctor after taking the SET as quickly as possible. These elements...
High levels of genetic diversity of <em>Plasmodium falciparum</em> populations in Papua New Guinea despite variable infection prevalence (Publications)
obstacle to malaria control. Here, we investigate the relationship between local variation in malaria epidemiology and parasite genetic diversity in Papua New Guinea (PNG). Cross-sectional malaria surveys [...] surveys were performed in 14 villages spanning four distinct malaria-endemic areas on the north coast, including one area that was sampled during the dry season. High-resolution msp2 genotyping of 2,147 blood
Bite Interruption Towards Elimination (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/bite-interruption-towards-elimination
progress in reducing malaria transmission in the Greater Mekong Subregion (GMS). However progress has stalled with reports of increase in the number of cases, multi-drug resistant malaria and pyrethroid-resistant [...] mobile and migrant populations, including forest-goers and forest rangers. Many of the dominant malaria vectors in the region feed and rest outdoors yet there is limited available protection against mosquito [...] populations. To address these pressing challenges, the University...
Antimalarial Drug Screening (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/antimalarial-drug-screening
performed by Medicines for Malaria Venture in 2009 and showed that OZ439 is well tolerated at all dose levels. So called 'proof of concept' phase II clinical trials with malaria patients showed that the [...] Our mandate with Medicines for Malaria Venture in Geneva comprises exploratory work on novel compounds from various sources. The goal is to identify novel chemical entities showing antimalarial activity [...] during the last decade is that such novel compounds can ultimately become part of...
Bite Interruption Towards Elimination (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/bite-interruption-towards-elimination
progress in reducing malaria transmission in the Greater Mekong Subregion (GMS). However progress has stalled with reports of increase in the number of cases, multi-drug resistant malaria and pyrethroid-resistant [...] mobile and migrant populations, including forest-goers and forest rangers. Many of the dominant malaria vectors in the region feed and rest outdoors yet there is limited available protection against mosquito [...] populations. To address these pressing challenges, the University...