Heterochromatin protein 1 secures survival and transmission of malaria parasites (Publications)
variant expression of surface antigens allows the malaria parasite Plasmodium falciparum to evade immune recognition during blood stage infection and secure malaria transmission. We demonstrate that heterochromatin [...] have major implications for developing antidisease and transmission-blocking interventions against malaria.
Asymptomatic malaria infections: detectability, transmissibility and public health relevance (Publications)
even in low-endemic areas. In this Opinion article, we describe the detectability of asymptomatic malaria infections and the relevance of submicroscopic infections for parasite transmission to mosquitoes [...] deployment of molecular diagnostic tools is needed to provide adequate insight into the epidemiology of malaria and infection dynamics to aid elimination efforts
Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global... (Publications)
living with malaria is larger than estimated by WHO. The number of people living with HIV, tuberculosis, or malaria have all decreased since 2000. At the global level, upward trends for malaria and HIV deaths [...] all parameters. We analysed malaria mortality and incidence using an updated cause of death database, a systematic analysis of verbal autopsy validation studies for malaria, and recent studies (2010-13) [...] 1.4 million) in 2004. Since 2004, child deaths from malaria in sub-Saharan...
Malaria vector control at crossroads: public health entomology and the drive to elimination (Publications)
control has been at the core of successful malaria control. However, a dearth of field-oriented vector biologists threatens to undermine global reductions in malaria burden. Skilled cadres are needed to manage [...] increasingly heterogeneous. Recognising this human resource crisis, in September 2013, WHO Global Malaria Programme issued guidance for capacity building in entomology and vector control, including reco [...] generation of public health entomologists that will enable programmes to...
Beyond malaria: causes of fever in outpatient Tanzanian children (Publications)
parasitic infection other than malaria or typhoid fever was found in 13.3% of children, nasopharyngeal viral infection (without respiratory symptoms or signs) in 11.9%, malaria in 10.5%, gastroenteritis in [...] BACKGROUND: As the incidence of malaria diminishes, a better understanding of nonmalarial fever is important for effective management of illness in children. In this study, we explored the spectrum of
Interventions that effectively target <em>Anopheles funestus</em> mosquitoes could significantly improve control of persistent malaria transmission in... (Publications)
Malaria is transmitted by many Anopheles species whose proportionate contributions vary across settings. We re-assessed the roles of Anopheles arabiensis and Anopheles funestus, and examined potential [...] potential benefits of species-specific interventions in an area in south-eastern Tanzania, where malaria transmission persists, four years after mass distribution of long-lasting insecticide-treated nets (LLINs) [...] arabiensis (44.1%). Though An. arabiensis is still the most abundant vector...