Profile: the rusinga health and demographic surveillance system, western Kenya (Publications)
2012 to facilitate a malaria intervention trial: the SolarMal project. The project aims to eliminate malaria from Rusinga Island using the nationwide adopted strategy for malaria control (insecticide-treated [...] surveillance is to measure the effectiveness of the trial on clinical malaria incidence, and to monitor demographic, environmental and malaria-related data variables. At the end of 2014, the 44 km2 island had [...] surveyed for clinical malaria. Following each round of surveillance, a...
From <em>Plasmodium vivax</em> outbreak to elimination: lessons learnt from a retrospective analysis of data from Guantang (Publications)
BACKGROUND: Malaria was once a serious public health problem in China, with Plasmodium vivax the major species responsible for more than 90% of local transmission. Following significant integrated malaria control [...] control and elimination programmes, malaria burden declined, and since 2017 China has not recorded any indigenous case. To understand the historical malaria transmission patterns and epidemic characteristics [...] regarding Anopheles sinensis. RESULTS: Following 25 years of...
Spatial patterns of <em>Plasmodium vivax</em> transmission explored by multivariate auto-regressive state-space modelling - a case study in Baoshan... (Publications)
The transition from the control phase to elimination of malaria in China through the national malaria elimination programme has focussed attention on the need for improvement of the surveillance- response [...] (IDIRMS). The best MARSS model indicated that malaria transmission in the study area during 36 months could be grouped into three clusters. The estimation of malaria transmission patterns showed a downward trend [...] cluster cases have occurred. This study aims to explore the spatial...
Impact de l'urbanisation sur l'indice plasmodique et les densités parasitaires chez les enfants de 0 à 5 ans dans la commune de Yopougon, Abidjan... (Publications)
microscope after staining. The malaria infection rate was 21.8%, indicating mesoendemic malaria. Its distribution varied significantly between the three urbanization levels. Malaria parasite densities also varied [...] to determine the impact of urbanization on the malaria infection (parasite) rate and parasite density, and their consequences on the heterogeneity of malaria transmission in urban Abidjan. Specifically we [...] tly between them. These results confirm the involvement of...
A prospective study of <em>Plasmodium falciparum</em> multiplicity of infection and morbidity in Tanzanian children (Publications)
individuals with substantial previous exposure to malaria, co-infection with multiple clones of Plasmodium falciparum can protect against subsequent clinical malaria attacks. Other studies, mainly of individuals [...] These results provide further evidence that relationships between asymptomatic malaria infections and clinical malaria change with cumulative exposure. [...] multiplicity of infection increased with age. In the first year of life, the incidence of clinical malaria was almost three...
Rapid spread of double East- and West-African <em>kdr </em>mutations in wild <em>Anopheles coluzzi</em> from Côte d'Ivoire (Publications)
decrease of malaria burden. These tools are now threatened by insecticide resistance in malaria vectors, which is spreading dramatically. After two different real-time polymerase chain reaction molecular char [...] resistance in malaria vectors and highlight the urgent need to diversify the methods of vector control in order to avoid the failure of insecticide-based vector control tools which may favor malaria fatalities [...] Malaria morbidity and mortality rates in Sub-Saharan Africa are...
Identifying risk factors for <em>Plasmodium </em>infection and anaemia in Kinshasa, Democratic Republic of Congo (Publications)
risk factors for malaria infection in large cities in central Africa and in all age groups. There may be different associations with the risk factors for areas with different malaria transmission intensities [...] (non-rural), collected during a cross sectional malaria survey in 2011. Logistic regression with random effects was used to investigate predictors for malaria and anaemia. Differences in risk factors in areas [...] whereas it increased with malaria infection and reported fever. ITN use...
Absence of dry season <em>Plasmodium</em> parasitaemia, but high rates of reported acute respiratory infection and diarrhoea in presschool-aged... (Publications)
epidemiology of malaria in the Senegal River Gorgol valley, southern Mauritania, requires particular attention in the face of ongoing and predicted environmental and climate changes. While "malaria cases" are [...] ons in neighbouring regions point to an absence of malaria transmission in mosquito vectors in the dry season. Because the clinical signs of malaria are non-specific and overlap with those of other diseases [...] diseases (e.g. acute respiratory infections and diarrhoea), new research...
Global diversity and balancing selection of 23 leading <em>Plasmodium falciparum </em>candidate vaccine antigens (Publications)
leading vaccine candidate antigens of P. falciparum using the MalariaGEN Pf3K (version 5.1) resource, comprising more than 2600 genomes from 15 malaria endemic countries. A stringent variant calling pipeline [...] genes encoding 23 leading and novel candidate malaria vaccine antigens including csp, trap, eba175, ama1, rh5, and CelTOS. Our analysis shows that current malaria vaccine formulations are based on rare haplotypes [...] Investigation of the diversity of malaria parasite antigens can...
The risk of malarial infections and disease in Papua New Guinean children (Publications)
vivax = 5.28), they were 21 times more likely to develop symptomatic P. falciparum malaria (1.17/year) than P. vivax malaria (0.06/year). Children greater than nine years of age had a reduced risk of acquiring [...] to symptomatic P. falciparum malaria remained incomplete. These observations suggest that different mechanisms of immunity may be important for protection from these malaria species [...] study of 206 Papua New Guinean school children, we examined risk of reinfection and symptomatic ...