Multi-insecticide resistant malaria vectors in the field remain susceptible to malathion, despite the presence of <em>Ace1</em> point mutations (Publications)
Insecticide resistance in Anopheles mosquitoes is seriously threatening the success of insecticide-based malaria vector control. Surveillance of insecticide resistance in mosquito populations and identifying the
<em>Plasmodium falciparum</em> parasite prevalence in East Africa: updating data for malaria stratification (Publications)
Burden High Impact (HBHI) strategy for malaria encourages countries to use multiple sources of available data to define the sub-national vulnerabilities to malaria risk, including parasite prevalence. Here [...] to provide a more contemporary understanding of the sub-national malaria prevalence stratification across the sub-region for 2019. Malaria prevalence data from surveys undertaken between January 2010 and
Detection of asymptomatic malaria in Asian countries: a meta-analysis of diagnostic accuracy (Publications)
Background: Achieving malaria elimination requires the targeting of the human reservoir of infection, including those patients with asymptomatic infection. The objective was to synthesise evidence on the [...] accuracy of the rapid- onsite diagnostic tests (RDTs) and microscopy for the detection of asymptomatic malaria as part of the surveillance activities in Asian countries. Methods: This was a meta-analysis of [...] that evaluated the diagnostic per- formance of RDTs and microscopy for...
Multi-dose priming regimens of PfSPZ vaccine: safety and efficacy against controlled human malaria infection in Equatoguinean adults (Publications)
Tolerability, safety, immunogenicity, and vaccine efficacy (VE) against homologous-controlled human malaria infection (CHMI) 6-7 weeks after vaccination were assessed to down-select the best regimen. All four
Emulator-based Bayesian optimization for efficient multi-objective calibration of an individual-based model of malaria (Publications)
framework employing Gaussian process or machine learning emulator functions to calibrate a complex malaria transmission simulator. We demonstrate our approach by optimizing over a high-dimensional parameter [...] a portfolio of multiple fitting objectives built from datasets capturing the natural history of malaria transmission and disease progression. Our approach quickly outperforms previous calibrations, yielding
Unlocking the human factor to increase effectiveness and sustainability of malaria vector control (Publications)
decade in the fight against malaria there is a critical opportunity to elevate the role of social and behaviour change to increase the impact and sustainability of malaria control and elimination efforts [...] BACKGROUND: Progress in the fight against malaria has stalled in recent years, highlighting the importance of new interventions and tailored approaches. A critical factor that must be considered across [...] research with entomological and epidemiological evaluations will provide a more...