Exploring a tetrahydroquinoline antimalarial hit from the medicines for malaria pathogen box and the identification of its mode of resistance as... (Publications)
of 400 compounds that was made available by Medicines for Malaria Venture (MMV) in 2015. Compound 2 was profiled in in vitro models of malaria and was found to be active against multiple life-cycle stages
Spatial prediction of malaria prevalence in Papua New Guinea: a comparison of Bayesian decision network and multivariate regression modelling... (Publications)
performance when developing malaria prevalence maps due to the multiple interacting factors that drive malaria prevalence in different geographical areas. When developing malaria prevalence maps, BDNs may [...] BACKGROUND: Considerable progress towards controlling malaria has been made in Papua New Guinea through the national malaria control programme's free distribution of long-lasting insecticidal nets, improved [...] linear model, GLM) in terms of malaria spatial risk prediction accuracy....
Investigating differences in village-level heterogeneity of malaria infection and household risk factors in Papua New Guinea (Publications)
Malaria risk is highly heterogeneous. Understanding village and household-level spatial heterogeneity of malaria risk can support a transition to spatially targeted interventions for malaria elimination [...] spatial heterogeneity of malaria risk and investigate the contribution of individual, household and environmental-level risk factors. Following a period of declining malaria prevalence, the prevalence [...] useful indicators of transmission hotspots and inform the development of tailored...
CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for <em>Plasmodium falciparum </em>malaria transmission research (Publications)
The malaria parasite Plasmodium falciparum replicates inside erythrocytes in the blood of infected humans. During each replication cycle, a small proportion of parasites commits to sexual development and [...] In summary, we believe the iGP approach developed here will greatly expedite basic and applied malaria transmission stage research.
Evaluation of different deployment strategies for larviciding to control malaria: a simulation study (Publications)
METHODS: A malaria transmission model, OpenMalaria, was used to simulate varying larviciding strategies and their impact on host-seeking mosquito densities, entomological inoculation rate (EIR) and malaria prevalence [...] BACKGROUND: Larviciding against malaria vectors in Africa has been limited to indoor residual spraying and insecticide-treated nets, but is increasingly being considered by some countries as a complementary [...] g were simulated for three transmission intensities and four...
A brief history of selected malaria vaccine and medical interventions pursued by the Swiss Tropical and Public Health Institute and partners,... (Publications)
research portfolio as key elements for researching and applying evidence in malaria control and elimination as part of national malaria control programmes. [...] perspective. Its aim is to highlight the above-mentioned transformation by focusing on selected malaria research-cum-action interventions during the crucial period of the 1990s, which were tailored to