Single-dose tafenoquine to prevent relapse of <em>Plasmodium vivax</em> malaria (Publications)
BACKGROUND: Treatment of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver (a treatment termed "radical
Structure–activity relationship studies and <em>Plasmodium</em> life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl... (Publications)
Structure-activity relationship studies involving N-aryl-3-trifluoromethyl pyrido[1,2-a] benzimidazoles (PBI) identified several compounds possessing potent in vitro activities against the asexual blo
Early antischistosomal leads identified from<em> in vitro</em> and<em> in vivo</em> screening of the Medicines for Malaria Venture pathogen box (Publications)
Facing an almost dry drug development pipeline, screening the Pathogen Box from the Medicines for Malaria Venture (MMV), provides a unique opportunity to possibly expand the pool of potent molecules against
Indigenous <em>Plasmodium malariae</em> infection in an endemic population at the Thai-Myanmar border (Publications)
Plasmodium malariae is a neglected malaria parasite. It has wide geographic distribution and, although often associated with mild malaria, is linked to a high burden of anemia and nephrotic syndromes. [...] 2013-June 2014 in which P. malariae infection was detected. Of the 812 study participants, two were found to be infected with P. malariae. One had an infection that led to acute malaria, but the other was positive [...] positive for P. malariae at multiple visits during the study and...
Global fund financing to the 34 malaria-eliminating countries under the new funding model 2014-2017: an analysis of national allocations and regional... (Publications)
BACKGROUND: The Global Fund to Fight AIDS, Tuberculosis, and Malaria (GFATM) has been the largest financial supporter of malaria since 2002. In 2011, the GFATM transitioned to a new funding model (NFM) [...] NFM to the 34 malaria-eliminating countries. METHODS: Average annual disbursements under the old funding model were compared to average annual national allocations for all eligible 34 malaria-eliminating [...] funding declines for malaria investments in low transmission countries, the GFATM...
Epidemiological links between malaria parasitaemia and hypertension: findings from a population-based survey in rural Côte d'Ivoire (Publications)
between malaria parasitaemia and hypertension in Ivorian adults. METHODS: We estimated the adjusted odds ratios (OR) and 95% confidence intervals (CI) of hypertension in relation to malaria parasitaemia [...] mmHg or clinician-diagnosed hypertension. RESULTS: Prevalence of malaria parasitaemia and hypertension were 10 and 22%, respectively. Malaria parasitaemia was negatively associated with hypertension in p [...] Participants having microscopic malaria parasitaemia with elevated body...
Immuno-gold silver staining assays on capillary-driven microfluidics for the detection of malaria antigens (Publications)
a lack of highly sensitive malaria RDTs that can detect low antigen concentration at the onset of infection. Here, we present a strategy to improve the sensitivity of malaria RDTs by using capillary-driven [...] al to the concentration of antigen in a sample. We illustrate this method using the recombinant malaria antigen Plasmodium falciparum histidine-rich-protein 2 (rPfHRP2) spiked in human serum. This antigen [...] min, which is approaching the desired sensitivity needed in the Target...
Nationwide school malaria parasitaemia survey in public primary schools, the United Republic of Tanzania (Publications)
school, malaria survey was implemented to assess the risk factors of malaria prevalence and bed net use among primary school children in mainland Tanzania. This allowed the mapping of malaria prevalence [...] for malaria infection and for bed net use while adjusting for school effect. RESULTS: In total, 49,113 children were interviewed and tested for malaria infection. The overall prevalence of malaria was [...] prevalence at council level and assessment of malaria risk factors among school...