Adherence to prescribed artemisinin-based combination therapy in Garissa and Bunyala districts, Kenya (Publications)
anti-malarial mono-therapies, malaria endemic countries in Africa now use artemisinin-based combination therapy (ACT) as recommended first-line treatment for uncomplicated malaria. Patients' adherence to ACT
Composition and stage dynamics of mitochondrial complexes in<em> Plasmodium falciparum</em> (Publications)
organisms, which only represent a fraction of eukaryotic diversity. The unusual mitochondrion of malaria parasites is a validated drug target but remains poorly understood. Here, we apply complexome profiling
Translation of liver stage activity of M5717, a <em>Plasmodium</em> elongation factor 2 inhibitor: from bench to bedside (Publications)
stage of Plasmodium infection through chemoprevention could become a key intervention to reduce malaria-associated incidence and mortality. METHODS: M5717, a Plasmodium elongation factor 2 inhibitor, was
Phytochemical study and antiprotozoal activity of compounds isolated from <em>Thalia geniculata</em> (Publications)
Thalia geniculata L. (Marantaceae) is an African medicinal plant traditionally used in Benin to treat malaria and other parasitic diseases. There is little ethnobotanical and almost no chemical information available
Joziknipholones A and B: the first dimeric phenylanthraquinones from the roots of <em>Bulbine frutescens</em> (Publications)
M-configured. Joziknipholones A and B are active against the chloroquine resistant strain K1 of the malaria pathogen, Plasmodium falciparum, and show moderate activity against murine leukemic lymphoma L5178y
Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities (Publications)
plausible explanation for lack of significant activity of the inhibitors in the in vivo Pb mouse malaria model
In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models (Publications)
(OZ277) is a promising antimalarial drug candidate that Ranbaxy Laboratories Limited and Medicines for Malaria Venture (MMV) are currently developing as a fixed combination with piperaquine. Here, we describe
Abnormal blood glucose concentrations on admission to a rural Kenyan district hospital: prevalence and outcome (Publications)
a on admission was 7.3%. Severe illness, malnutrition, last meal > 12 hours ago, and a positive malaria slide were independently associated with hypoglycaemia. Overall, mortality in hypoglycaemic children
<em>In silico</em> guided reconstruction and analysis of ICAM-1-binding var genes from <em>Plasmodium falciparum</em> (Publications)
the surface of infected erythrocytes is thought to play a major role in the pathology of severe malaria. As the sequence pool of the var genes encoding PfEMP1 expands there are opportunities, despite the
Flow cytometric analysis on cross-reactivity of human-specific CD monoclonal antibodies with splenocytes of <em>Aotus nancymaae</em>, a non-human... (Publications)
to explore complex host-pathogen interactions in non-human primate animal models, particularly in malaria vaccine research