Antiprotozoal activities of traditional medicinal plants from the Garhwal region of North West Himalaya, India (Publications)
Garhwal region of North West Himalaya for the treatment of protozoal infections and fever including malaria. MATERIALS AND METHODS: In vitro activity against erythrocytic stages of Plasmodium falciparum was
Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on... (Publications)
sub-micromolar range against Trypanosoma brucei rhodesiense and Trypanosoma cruzi, as well as the malaria parasite Plasmodium falciparum, which lack trypanothione metabolism. The inhibitors exhibit strong
Antiprotozoal activities of some constituents of <em>Markhamia tomentosa</em> (Bignoniaceae) (Publications)
bloodstream trypomastigotes of Trypanosoma brucei rhodesiense (the species responsible for human malaria, visceral leishmaniasis and African trypanosomiasis, respectively). Although compounds 1 and 2 exhibited
Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5'-carboxamidoadenosine analogues (Publications)
rapid increase of resistance to drugs commonly used in the treatment of tropical diseases such as malaria and African sleeping sickness calls for the prompt development of new safe and efficacious drugs
Genesis of and trafficking to the Maurer's clefts of <em>Plasmodium falciparum</em>-infected erythrocytes (Publications)
Malaria parasites export proteins beyond their own plasma membrane to locations in the red blood cells in which they reside. Maurer's clefts are parasite-derived structures within the host cell cytoplasm
Antiplasmodial and antitrypanosomal activity of new esters and ethers of 4-dialkylaminobicyclo[2.2.2]octan-2-ols (Publications)
suffer from painful application, severe side effects and increasing resistance against these drugs. Malaria tropica kills more than 2 million people every year mainly due to growing drug resistance. 4-Dia
A <em>Plasmodium falciparum</em> bromodomain protein regulates invasion gene expression (Publications)
expression of invasion genes and indicate that targeting PfBDP1 could be an invaluable tool in malaria eradication
Host cytoskeleton remodeling throughout the blood stages of <em>Plasmodium falciparum</em> (Publications)
asexual intraerythrocytic development of Plasmodium falciparum, causing the most severe form of human malaria, is marked by extensive host cell remodeling. Throughout the processes of invasion, intracellular
<em>Plasmodium berghei </em>subunit vaccine: repeat synthetic peptide of circumsporozoite protein comprising T- and B-cell epitopes fails to confer... (Publications)
In the murine malaria model induced by Plasmodium berghei, we studied the immunogenicity of the repeat region of the circumsporozoite (CS) protein, which is the main target of the antibody response in
Enrichment of a single clone from a high diversity library of phage-displayed antibodies by panning with<em> Anopheles gambiae </em>(Diptera:... (Publications)
suggest that the selection of sufficiently diverse antibody panels, from which mosquitocidal or malaria transmission-blocking antibodies can be isolated, may require improved selection methods or specifically