Quantifying behavioural interactions between humans and mosquitoes: Evaluating the protective efficacy of insecticidal nets against malaria... (Publications)
ABSTRACT: BACKGROUND: African malaria vectors bite predominantly indoors at night so sleeping under an Insecticide-Treated Net (ITN) can greatly reduce malaria risk. Behavioural adaptation by mosquitoes [...] allow vector mosquitoes to bite outside of peak sleeping hours and undermine efficacy of this key malaria prevention measure. METHODS: High coverage with largely untreated nets has been achieved in the Kilombero [...] peak sleeping hours, respectively. ITNs consistently conferred > 70%...
Preventing childhood malaria in Africa by protecting adults from mosquitoes with insecticide-treated nets (Publications)
BACKGROUND: Malaria prevention in Africa merits particular attention as the world strives toward a better life for the poorest. Insecticide-treated nets (ITNs) represent a practical means to prevent malaria in [...] targets for ITN coverage beyond vulnerable groups. METHODS AND FINDINGS: Using field-parameterized malaria transmission models, we show that high (80% use) but exclusively targeted coverage of young children
Measures of clinical malaria in field trials of interventions against <em>Plasmodium falciparum</em> (Publications)
IIb or III malaria vaccine trials were simulated corresponding to each of a pre-erythrocytic, blood stage, and anti-disease vaccine, each in a population with 80% prevalence of patent malaria infection [...] BACKGROUND: Standard methods for defining clinical malaria in intervention trials in endemic areas do not guarantee that efficacy estimates will be unbiased, and do not indicate whether the intervention [...] between morbidity and parasite density and the performance of different case...
Inaugural meeting of the malaria policy advisory committee to the WHO: conclusions and recommendations (Publications)
conclusions and recommendations from that meeting, as part of the newly launched Malaria Journal thematic series "WHO Malaria Policy Advisory Committee: Reports and Recommendations".Summaries are provided [...] sessions on global malaria control, drug resistance and containment, rapid diagnostic test procurement criteria, larviciding, classification of countries for elimination, estimating malaria cases and deaths [...] The Malaria Policy Advisory Committee to the World Health Organization met...
Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial (Publications)
indicates that a combination vaccine targeting different stages of the malaria life cycle is likely to provide the most effective malaria vaccine. This trial was the first to combine two existing vaccination [...] ts were healthy, malaria naive volunteers, from Oxford. The interventions were vaccination with PEV3A alone, or PEV3A+FFM ME-TRAP. The main outcome measure was protection from malaria in a sporozoite challenge [...] stages of the P. falciparum life cycle. METHODS: This was a Phase...
Ensemble modeling of the likely public health impact of a pre-erythrocytic malaria vaccine (Publications)
BACKGROUND: The RTS,S malaria vaccine may soon be licensed. Models of impact of such vaccines have mainly considered deployment via the World Health Organization's Expanded Programme on Immunization (EPI)
Implementation of the global plan for insecticide resistance management in malaria vectors: progress, challenges and the way forward (Publications)
resistance of malaria vectors to insecticides, particularly to pyrethroids which are widely used in insecticide-treated nets. The Global Plan for Insecticide Resistance Management in malaria vectors (GPIRM) [...] to effective malaria prevention. Aligning efforts and assigning the needed resources will ensure the optimal implementation of GPIRM with the ultimate goal of maintaining effective malaria vector control [...] (GPIRM), released in May 2012, is a collective strategy for the malaria...
Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of seventh biannual meeting (March 2015) (Publications)
reviews or consultations on malaria terminology, malaria in pregnancy, and the feasibility of eradication; as well as updates from the World Health Organization Global Malaria Programme regarding their strategy [...] The Malaria Policy Advisory Committee to the World Health Organization held its seventh meeting in Geneva, Switzerland from 5 to 7 March 2015. This article provides a summary of the discussions, conclusions [...] policy setting processes. Policy statements, position statements, and...
The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient... (Publications)
d Plasmodium falciparum malaria in Africa. We investigated the impact of different dosing strategies on the efficacy of this combination for the treatment of falciparum malaria. METHODS: Individual patient