Risk of imported malaria infections in Zanzibar: a cross-sectional study (Publications)
and the risk of malaria infection, may help to control malaria importation to Zanzibar. METHODS: A rolling cross-sectional survey linked to routine reactive case detection of malaria was carried out in [...] and October 2018. Households of patients diagnosed with malaria at health facilities were surveyed and household members were tested for malaria using rapid diagnostic tests and a sub-sample by quantitative [...] trips within and outside of Zanzibar. We estimated the association of malaria...
Species composition, infection rate and detection of resistant alleles in <em>Anopheles funestus</em> (Diptera: Culicidae) from Lare, a malaria... (Publications)
BACKGROUND: Anopheles funestus, which is considered as secondary vector of malaria in Ethiopia, is known to have several morphologically indistinguishable (sibling) species. Accurate identification of [...] wild type. None of the samples (Nā=ā169) were found positive for Plasmodium (P. falciparum/ovale/malariae/vivax) detection. CONCLUSION: All An. funestus s.l. samples from Lare were molecularly identified
Malaria elimination in Zanzibar: where next? (Publications)
progress made towards malaria elimination, effectiveness of the health systems in delivering malaria case management; and malaria financing. A desk review examined available malaria data, annual work plans [...] 2018, Zanzibar developed a national malaria strategic plan IV (2018-2023) to guide elimination of malaria by 2023. We assessed progress in the implementation of malaria activities as part of the end-term [...] with marked heterogeneity between areas. However, about 68% of the detected ma...
Hearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide target (Publications)
Malaria mosquitoes acoustically detect their mating partners within large swarms that form transiently at dusk. Indeed, male malaria mosquitoes preferably respond to female flight tones during swarm time
The malaria blood stage antigen <em>Pf</em>CyRPA formulated with the TLR-4 agonist adjuvant GLA-SE elicits parasite growth inhibitory antibodies in... (Publications)
BACKGROUND: Plasmodium falciparum cysteine-rich protective antigen (PfCyRPA) is an invasion complex protein essential for erythrocyte invasion. In contrast to several previously clinically tested mero
Malaria rapid diagnostic tests reliably detect asymptomatic <em>Plasmodium falciparum</em> infections in school-aged children that are infectious to... (Publications)
this study, malaria rapid diagnostic tests (mRDT), light microscopy (LM) and quantitative polymerase chain reaction (qPCR) were used to evaluate their performance detecting asymptomatic malaria infections [...] BACKGROUND: Asymptomatic malaria infections (Plasmodium falciparum) are common in school-aged children and represent a disease transmission reservoir as they are potentially infectious to mosquitoes. To [...] was 31.7% by qPCR, 18.2% by mRDT and 9.4% by LM. Approximately one-third (31.2%)...
Geo-epidemiology of malaria incidence in the Vhembe District to guide targeted elimination strategies, South-Africa, 2015-2018: a local resurgence (Publications)
to classify the 474 smoothed malaria incidence curves. Thereafter, validity indices were used to determine the number of malaria incidence patterns. The cumulative malaria incidence of the study area was [...] Findings show also unusual malaria phenomena in Vhembe District that hinder malaria elimination in South Africa. Assessing the factors associated with these unusual malaria phenome would be helpful on [...] results. Therefore, in the process of refining local malaria control and...
Starting at the community: treatment-seeking pathways of children with suspected severe malaria in Uganda (Publications)
than five years with suspected severe malaria. An observational study in Uganda enrolled children below five years presenting to CHWs with signs of severe malaria. Children were followed up 28 days after [...] Community health workers (CHW) usually refer children with suspected severe malaria to the nearest public health facility or a designated public referral health facility (RHF). Caregivers do not always
Spatio-temporal modelling of routine health facility data for malaria risk micro-stratification in mainland Tanzania (Publications)
probability of malaria TPR exceeding programmatic threshold was estimated. Results showed a marked spatial heterogeneity in malaria TPR across wards. 17.7 million people resided in areas where malaria TPR was [...] As malaria transmission declines, the need to monitor the heterogeneity of malaria risk at finer scales becomes critical to guide community-based targeted interventions. Although routine health facility [...] million people lived in areas where malaria TPR was very low ( < 5%; 90%...
Variability in white blood cell count during uncomplicated malaria and implications for parasite density estimation: a WorldWide Antimalarial... (Publications)
count during acute uncomplicated malaria, and estimate the impact of using an assumed value of WBC on estimates of parasite density and clearance. METHODS: Uncomplicated malaria drug efficacy studies that measured [...] and vivax (n = 2678) malaria, respectively. At presentation, higher WBC counts were seen among patients with higher parasitaemia, severe anaemia and, for individuals with vivax malaria, in regions with shorter [...] reference. RESULTS: Eighty-four studies enrolling 27,656...