The malaria vaccine epidemiology and evaluation project of Papua New Guinea: rationale and baseline studies (Publications)
possible malaria vaccines, against different species of Plasmodium and various stages in the life cycle of the parasite in both human host and mosquito vector, is reviewed. The importance, in a malaria-endemic [...] The variety of immune responses to malaria is set out and linked to both human and plasmodial genetic factors. Host genetics may also modify susceptibility to malaria through mechanisms which are not i [...] epidemiological evaluation are specified. After this brief review of malaria...
Effects of vector-control interventions on changes in risk of malaria parasiotaemia in sub-Saharan Africa: a spatial and temporal analysis (Publications)
episodes and deaths due to malaria have been mainly associated with the expansion of vector-control measures, such as insecticide-treated bednets and indoor residual spraying. Malaria indicator surveys gather [...] gather information about key malaria indicators through national representative household surveys. We aimed to estimate changes in risk of malaria parasitaemia at high spatial resolution in sub-Saharan Africa [...] that had publicly available data from two malaria indicator or...
Metabolic profiling framework for discovery of candidate diagnostic markers of malaria (Publications)
Despite immense efforts to combat malaria in tropical and sub-tropical regions, the potency of this vector-borne disease and its status as a major driver of morbidity and mortality remain undisputed. We
Geostatistical modelling of the malaria risk in Mozambique: effect of the spatial resolution when using remotely-sensed imagery (Publications)
literature exists on the relationship between malaria and environmental/climatic factors in different geographical areas, but few studies have linked human malaria parasitemia survey data with remote sensi [...] The study of malaria spatial epidemiology has benefited from recent advances in geographic information system and geostatistical modelling. Significant progress in earth observation technologies has led [...] classes and assess the effect of the spatial resolution of remotely sensed land...
The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. II. Mortality and morbidity (Publications)
Malaria mortality and morbidity were studied in a rural population of 4000 in the Wosera area, East Sepik Province, Papua New Guinea. Malaria accounted for 4.9% of the 162 deaths investigated by verbal [...] at the beginning of the wet season. The geographical distribution of malaria morbidity was not uniform. The measurement of malaria-related morbidity, the identification of significant seasonal and local [...] verbal autopsy and for 12.2% of the 49 deaths assessed through medical records. Mal...
Retail sector distribution chains for malaria treatment in the developing world: a review of the literature (Publications)
availability, quality and price of malaria treatment. This article presents the findings of a systematic literature review on the retail sector distribution chain for malaria treatment in low and middle-income [...] sector malaria treatment was mainly descriptive and lacked representative data on a national scale. These are important limitations in the advent of the Affordable Medicine Facility for Malaria, which [...] BACKGROUND: In many low-income countries, the retail sector plays an...
Comparative analysis of two methods for measuring sales volumes during malaria medicine outlet surveys (Publications)
BACKGROUND: There is increased interest in using commercial providers for improving access to quality malaria treatment. Understanding their current role is an essential first step, notably in terms of the volume [...] methods. METHODS: Using sales volume data on anti-malarials and rapid diagnostic tests (RDTs) for malaria collected through provider recall (RC) and retail audits (RA), this study measures the degree of
Forscher im Kampf gegen Malaria [TV Broadcast] (Publications)
Malaria gehört zu den drei schlimmsten Infektionskrankheiten der Welt, neben Tuberkulose und HIV. Basler Wissenschaftler haben eine ganz neue Substanz entdeckt, die den hartnäckigen Erreger töten kann
Country specific predictions of the cost-effectiveness of malaria vaccine RTS,S/AS01 in endemic Africa (Publications)
evaluated at country levels of malaria parasite prevalence, coverage of control interventions and immunization. Benefits and costs of the program incremental to routine malaria control were evaluated for a [...] potential to substantially reduce malaria burden in children across Africa. Conditional on assumptions on price, coverage, and vaccine properties, adding RTS,S to routine malaria control interventions would [...] If implemented in all 43 countries the vaccine has the potential to avert...