Outpatient treatment of imported uncomplicated <em>Plasmodium falciparum</em> malaria: results from a survey among TropNet and GeoSentinel experts for... (Publications)
BACKGROUND: Plasmodium falciparum malaria (P.f. malaria) is frequently imported to non-endemic countries. Recommendations on outpatient treatment differ largely due to differences in country-level guidelines [...] TropNet or GeoSentinel referral centres for tropical medicine outside malaria endemic areas investigated common practices in P.f. malaria management, selection criteria for outpatient management and diagnostic [...] of the centres are located in Europe (n = 37). Overall, 27 centres...
Patterns of age-specific mortality in children in endemic areas of sub-Saharan Africa (Publications)
of the age- and season- dependence of malaria mortality is an important prerequisite for epidemiologic models of malaria immunity. However, most studies of malaria mortality have aggregated their results [...] stable endemic Plasmodium falciparum malaria. We use verbal autopsies (VAs) to estimate the proportion of deaths by age group due to malaria, and thus calculate malaria-specific mortality rates for each site [...] attributed to malaria. The overall age patterns of malaria mortality were...
Human unconventional T cells in <em>Plasmodium falciparum</em> infection (Publications)
field of malaria immunology. Significant advances in our basic understanding of unconventional T cell biology in rodent malaria models have been made, however, their roles in humans during malaria are less [...] tissues, and long-lasting expansions and functional alterations were observed upon malaria infection in malaria naïve and malaria pre-exposed volunteers. Here, we review the current understanding of involvement [...] Malaria is an old scourge of humankind and has a large negative impact...
A good night's sleep and the habit of net use: perceptions of risk and reasons for bed net use in Bukoba and Zanzibar (Publications)
BACKGROUND: Intensive malaria control interventions in the United Republic of Tanzania have contributed to reductions in malaria prevalence. Given that malaria control remains reliant upon continued use [...] perceived risk of malaria had decreased among the respondents, and malaria control interventions were credited for the decline. Participants cited reductions in both the severity of malaria and in their perceived [...] perceived susceptibility to malaria. However, malaria was still...
Antigens released at schizont burst stimulate <em>Plasmodium falciparum</em>-specific CD4+ T cells from non-exposed donors: potential for... (Publications)
individuals can be stimulated by malaria parasites. Here, we show that nine from 11 blood samples, naturally infected with malaria parasites, could stimulate proliferation of a malaria-specific T cell clone derived [...] the T cell response of naive donors to malaria parasites, processing of parasite antigens is blocked by chloroquine and monensin, and activation of 36 of 41 malaria-specific clones tested was restricted [...] activation of cross-reactive memory T cells by malaria parasites...
Effects of age, gender and soil-transmitted helminth infection on prevalence of <em>Plasmodium </em>infection among population living in Bata... (Publications)
bed nets. Malaria infections were detected in 34.8% of the participants, while 50% of malaria infections were reported in children aged 10-17 years. Females had a lower prevalence of malaria (28.8%) compared [...] health impact of STH and malaria co-infection is inconclusive. The current study aimed to report the malaria and STH infection epidemiology in the continental region of Equatorial Guinea. METHODS: We performed [...] infected with T. trichiura had malaria parasites compared with those...
Introducing insecticide-treated nets in the Kilombero Valley, Tanzania: the relevance of local knowledge and practice for an information, education... (Publications)
practice relating to malaria. The findings show that the biomedical concept of malaria overlaps with several local illness concepts, one of which is called malaria and refers to mild malaria. Most respondents [...] linked malaria to mosquitoes (76%) and already used mosquito nets (52%). But local understandings of severe malaria differed from the biomedical concept and were not linked to mosquitoes or malaria. A social [...] Since 1997 the WHO has been recommending an integrative strategy to...
Profile: the rusinga health and demographic surveillance system, western Kenya (Publications)
2012 to facilitate a malaria intervention trial: the SolarMal project. The project aims to eliminate malaria from Rusinga Island using the nationwide adopted strategy for malaria control (insecticide-treated [...] surveillance is to measure the effectiveness of the trial on clinical malaria incidence, and to monitor demographic, environmental and malaria-related data variables. At the end of 2014, the 44 km2 island had [...] surveyed for clinical malaria. Following each round of surveillance, a...
From <em>Plasmodium vivax</em> outbreak to elimination: lessons learnt from a retrospective analysis of data from Guantang (Publications)
BACKGROUND: Malaria was once a serious public health problem in China, with Plasmodium vivax the major species responsible for more than 90% of local transmission. Following significant integrated malaria control [...] control and elimination programmes, malaria burden declined, and since 2017 China has not recorded any indigenous case. To understand the historical malaria transmission patterns and epidemic characteristics [...] regarding Anopheles sinensis. RESULTS: Following 25 years of...