Mosquito nets and the poor: can social marketing redress inequities in access? (Publications)
Treated mosquito nets are a practical malaria control tool. However, implementation of efficient delivery mechanisms remains a challenge. We investigated whether social marketing of treated mosquito nets
Evidence that <em>Plasmodium falciparum</em> chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing... (Publications)
The malaria parasite Plasmodium falciparum undergoes antigenic variation through allelic exclusion and variant expression of surface proteins encoded by the var gene family. Regulation of var genes is
A <em>Plasmodium </em>membrane receptor platform integrates cues for egress and invasion in blood forms and activation of transmission stages (Publications)
Critical events in the life cycle of malaria-causing parasites depend on cyclic guanosine monophosphate homeostasis by guanylyl cyclases (GCs) and phosphodiesterases, including merozoite egress or invasion
Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities (Publications)
the low micromolar to submicromolar range against Trypanosoma brucei rhodesiense as well as the malaria parasite Plasmodium falciparum
Identification of nuclear proteins that differentially interact with <em>Plasmodium falciparum</em> var gene promoters (Publications)
PfEMP1 is responsible for both antigenic variation and cytoadherence of infected erythrocytes in malaria. Approximately 50 var genes per parasite genome code for this highly polymorphic surface protein
Maurer's clefts, the enigma of <em>Plasmodium falciparum</em> (Publications)
Plasmodium falciparum, the causative agent of malaria, completely remodels the infected human erythrocyte to acquire nutrients and to evade the immune system. For this process, the parasite exports more
Inhibition of <em>Plasmodium falciparum</em> Hsp90 contributes to the antimalarial activities of aminoalcohol-carbazoles (Publications)
Malaria caused by the protozoan parasite Plasmodium falciparum (Pf) remains a major public health problem throughout the developing world. One molecular target that should receive more attention is the
Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay (Publications)
BACKGROUND: Drug efficacy against kelch 13 mutant malaria parasites can be determined in vitro with the ring-stage survival assay (RSA). The conventional assay protocol reflects the exposure profile of
Gene Coverage Count and Classification (GC3): a locus sequence coverage assessment tool using short-read whole genome sequencing data, and its... (Publications)
BACKGROUND: The ability of malaria rapid diagnostic tests (RDTs) to effectively detect active infections is being compromised by the presence of malaria strains with genomic deletions at the hrp2 and hrp3
Significant geographical differences in prevalence of mutations associated with <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> drug... (Publications)
resistance remains a major obstacle to malaria treatment and control. It can arise and spread rapidly, and vary substantially even at sub-national level. National malaria programmes require cost-effective and